U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast Pleomorphic Adenoma

MedGen UID:
267412
•Concept ID:
C1511322
•
Neoplastic Process
Synonym: Pleomorphic Adenoma of the Breast

Definition

A rare, benign and well circumscribed neoplasm that arises from the breast. It is characterized by the proliferation of epithelial and myoepithelial cells surrounded by chondroid stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Pleomorphic Adenoma

Professional guidelines

PubMed

Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors.
Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169Free PMC Article
Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO
Histopathology 2016 Jan;68(1):45-56. doi: 10.1111/his.12861. PMID: 26348644Free PMC Article

Recent clinical studies

Etiology

TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
An atypically located pleomorphic adenoma: Radiological and pathological correlation.
Teh J, Dessauvagie B, Kessell M, Dissanayake D, Wylie EJ
J Med Imaging Radiat Oncol 2022 Feb;66(1):105-106. Epub 2021 Mar 25 doi: 10.1111/1754-9485.13178. PMID: 33768733
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Risk of breast cancer in women after a salivary gland carcinoma or pleomorphic adenoma in the Netherlands.
Valstar MH, Schaapveld M, van den Broek EC, van Velthuysen MF, de Ridder M, Schmidt MK, van Dijk BAC, Balm AJM, Smeele LE
Cancer Med 2021 Jan;10(1):424-434. Epub 2020 Nov 28 doi: 10.1002/cam4.3598. PMID: 33247629Free PMC Article
Pleomorphic adenoma of the breast: a clinicopathologic and immunohistochemical study of 10 cases.
Diaz NM, McDivitt RW, Wick MR
Hum Pathol 1991 Dec;22(12):1206-14. doi: 10.1016/0046-8177(91)90102-u. PMID: 1660850

Diagnosis

TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Pleomorphic adenoma of the breast with cytologic atypia on cytopathology: A potential diagnostic pitfall and literature review.
Boac BM, Centeno BA
Diagn Cytopathol 2022 May;50(5):265-269. Epub 2022 Jan 31 doi: 10.1002/dc.24933. PMID: 35100498
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
The morphological spectrum of salivary gland type tumours of the breast.
Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V
Pathology 2017 Feb;49(2):215-227. Epub 2016 Dec 30 doi: 10.1016/j.pathol.2016.10.011. PMID: 28043647
Pleomorphic adenoma of the breast: a clinicopathologic and immunohistochemical study of 10 cases.
Diaz NM, McDivitt RW, Wick MR
Hum Pathol 1991 Dec;22(12):1206-14. doi: 10.1016/0046-8177(91)90102-u. PMID: 1660850

Therapy

Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.
Fulciniti F, Losito NS, Botti G, Manola M, Ionna F
Diagn Cytopathol 2010 Jun;38(6):430-4. doi: 10.1002/dc.21229. PMID: 19894261
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization.
Lambros MB, Simpson PT, Jones C, Natrajan R, Westbury C, Steele D, Savage K, Mackay A, Schmitt FC, Ashworth A, Reis-Filho JS
Lab Invest 2006 Apr;86(4):398-408. doi: 10.1038/labinvest.3700390. PMID: 16446704
Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type.
Hayes MM, Lesack D, Girardet C, Del Vecchio M, Eusebi V
Virchows Arch 2005 Feb;446(2):142-9. Epub 2004 Dec 4 doi: 10.1007/s00428-004-1137-7. PMID: 15583933
Infarction after fine needle aspiration. A report of four cases.
Pinto RG, Couto F, Mandreker S
Acta Cytol 1996 Jul-Aug;40(4):739-41. doi: 10.1159/000333949. PMID: 8693896
Neurological deterioration after lumbar puncture below complete spinal subarachnoid block.
Hollis PH, Malis LI, Zappulla RA
J Neurosurg 1986 Feb;64(2):253-6. doi: 10.3171/jns.1986.64.2.0253. PMID: 3003263

Prognosis

PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway.
Li Y, Liu R, Han X, Xu W, Liu Y
Genes Genomics 2023 Jan;45(1):49-57. Epub 2022 Nov 18 doi: 10.1007/s13258-022-01330-0. PMID: 36399309
Risk of breast cancer in women after a salivary gland carcinoma or pleomorphic adenoma in the Netherlands.
Valstar MH, Schaapveld M, van den Broek EC, van Velthuysen MF, de Ridder M, Schmidt MK, van Dijk BAC, Balm AJM, Smeele LE
Cancer Med 2021 Jan;10(1):424-434. Epub 2020 Nov 28 doi: 10.1002/cam4.3598. PMID: 33247629Free PMC Article
The morphological spectrum of salivary gland type tumours of the breast.
Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V
Pathology 2017 Feb;49(2):215-227. Epub 2016 Dec 30 doi: 10.1016/j.pathol.2016.10.011. PMID: 28043647
Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO
Histopathology 2016 Jan;68(1):45-56. doi: 10.1111/his.12861. PMID: 26348644Free PMC Article
Pleomorphic adenoma of the breast: a clinicopathologic and immunohistochemical study of 10 cases.
Diaz NM, McDivitt RW, Wick MR
Hum Pathol 1991 Dec;22(12):1206-14. doi: 10.1016/0046-8177(91)90102-u. PMID: 1660850

Clinical prediction guides

TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Unusual pleomorphic adenoma of the lacrimal Gland: Immunohistochemical demonstration of PLAG1 and HMGA2 oncoproteins.
Jakobiec FA, Stagner AM, Eagle RC Jr, Lally SE, Krane JF
Surv Ophthalmol 2017 Mar-Apr;62(2):219-226. Epub 2016 Aug 25 doi: 10.1016/j.survophthal.2016.08.001. PMID: 27567603
Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO
Histopathology 2016 Jan;68(1):45-56. doi: 10.1111/his.12861. PMID: 26348644Free PMC Article
Immunohistochemical expression of progesterone receptors in pleomorphic adenoma and adenoid cystic carcinoma.
Safoura S, Mohamad E, Nosrat-Allah E, Fereshte E
J Cancer Res Ther 2011 Jan-Mar;7(1):23-8. doi: 10.4103/0973-1482.80440. PMID: 21546738
Pleomorphic adenoma of the breast: a clinicopathologic and immunohistochemical study of 10 cases.
Diaz NM, McDivitt RW, Wick MR
Hum Pathol 1991 Dec;22(12):1206-14. doi: 10.1016/0046-8177(91)90102-u. PMID: 1660850

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...