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Vitamin deficiency

MedGen UID:: 267607
•Concept ID:: C1510471
•: Disease or Syndrome

Synonyms:	Deficiencies, Vitamin; Deficiency, Vitamin; Vitamin Deficiencies; Vitamin Deficiency
SNOMED CT:	Vitamin deficiency (85670002); Hypovitaminosis (85670002)

Definition

A disorder that is caused by the deficiency of a vitamin. The deficiency may result from either suboptimal vitamin intake or conditions that prevent the vitamin''s use or absorption in the body. Representative examples include beriberi caused by thiamine deficiency, scurvy caused by vitamin C deficiency, and rickets caused by vitamin D deficiency. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVVitamin deficiency

Pathological process
- Disease
  - Non-Neoplastic Disorder
    - Non-Neoplastic Disorder by Special Category
      - Metabolic disease
        Nutritional disorder
        Vitamin deficiency
        Low levels of vitamin D
        Deficiency of vitamin D3
        Rickets
        Acquired Rickets
        Adult Rickets
        Calcium Deficiency Rickets
        Childhood Rickets
        Chronic kidney disease mineral and bone disorder
        Dent disease
        Familial X-linked hypophosphatemic vitamin D refractory rickets
        Hypocalcemic rickets
        Hypophosphatemic rickets
        Nutritional Rickets
        Vitamin D Dependent Rickets 2
        Vitamin D-dependent rickets
        Vitamin D-dependent rickets type II with alopecia
        Vitamin D-dependent rickets, type 2
        Vitamin D hydroxylation-deficient rickets, type 1B
        Vitamin D-dependent rickets, type 1
        Reduced circulating vitamin A concentration
        Scurvy
        Vitamin B deficiency
        Ariboflavinosis
        Maternal riboflavin deficiency
        Beriberi
        Choline deficiency disease
        Cobalamin deficiency
        Pernicious anemia
        Subacute combined degeneration of spinal cord
        Hyperhomocysteinemia
        Homocystinuria
        Low levels of vitamin B1
        Wernicke encephalopathy
        Pellagra
        Reduced blood folate concentration
        Reduced circulating vitamin B6 level
        Vitamin K deficiency
        Vitamin K Deficiency Bleeding

Professional guidelines

PubMed

Refeeding syndrome as treatment complication of anorexia nervosa.

Skowrońska A, Sójta K, Strzelecki D
Psychiatr Pol 2019 Oct 30;53(5):1113-1123. doi: 10.12740/PP/OnlineFirst/90275. PMID: 31955189

Acute cerebellar ataxia: differential diagnosis and clinical approach.

Pedroso JL, Vale TC, Braga-Neto P, Dutra LA, França MC Jr, Teive HAG, Barsottini OGP
Arq Neuropsiquiatr 2019 Mar;77(3):184-193. doi: 10.1590/0004-282X20190020. PMID: 30970132

Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.

Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490 Free PMC Article

See all (52)

Recent clinical studies

Etiology

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives.

Cosentino N, Campodonico J, Milazzo V, De Metrio M, Brambilla M, Camera M, Marenzi G
Nutrients 2021 Oct 14;13(10) doi: 10.3390/nu13103603. PMID: 34684604 Free PMC Article

Appropriate and inappropriate vitamin supplementation in children.

Martini L, Pecoraro L, Salvottini C, Piacentini G, Atkinson R, Pietrobelli A
J Nutr Sci 2020 Jun 5;9:e20. doi: 10.1017/jns.2020.12. PMID: 32577225 Free PMC Article

Acute cerebellar ataxia: differential diagnosis and clinical approach.

Pedroso JL, Vale TC, Braga-Neto P, Dutra LA, França MC Jr, Teive HAG, Barsottini OGP
Arq Neuropsiquiatr 2019 Mar;77(3):184-193. doi: 10.1590/0004-282X20190020. PMID: 30970132

B Vitamins and Ageing.

Mikkelsen K, Apostolopoulos V
Subcell Biochem 2018;90:451-470. doi: 10.1007/978-981-13-2835-0_15. PMID: 30779018

Hydrosoluble vitamins.

Chawla J, Kvarnberg D
Handb Clin Neurol 2014;120:891-914. doi: 10.1016/B978-0-7020-4087-0.00059-0. PMID: 24365359

See all (440)

Diagnosis

Severe megaloblastic anemia: Vitamin deficiency and other causes.

Socha DS, DeSouza SI, Flagg A, Sekeres M, Rogers HJ
Cleve Clin J Med 2020 Mar;87(3):153-164. doi: 10.3949/ccjm.87a.19072. PMID: 32127439

Acute cerebellar ataxia: differential diagnosis and clinical approach.

Pedroso JL, Vale TC, Braga-Neto P, Dutra LA, França MC Jr, Teive HAG, Barsottini OGP
Arq Neuropsiquiatr 2019 Mar;77(3):184-193. doi: 10.1590/0004-282X20190020. PMID: 30970132

Polyneuropathies.

Sommer C, Geber C, Young P, Forst R, Birklein F, Schoser B
Dtsch Arztebl Int 2018 Feb 9;115(6):83-90. doi: 10.3238/arztebl.2018.083. PMID: 29478436 Free PMC Article

Oral pathology in inflammatory bowel disease.

Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B
World J Gastroenterol 2016 Jul 7;22(25):5655-67. doi: 10.3748/wjg.v22.i25.5655. PMID: 27433081 Free PMC Article

Hydrosoluble vitamins.

Chawla J, Kvarnberg D
Handb Clin Neurol 2014;120:891-914. doi: 10.1016/B978-0-7020-4087-0.00059-0. PMID: 24365359

See all (284)

Therapy

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives.

Cosentino N, Campodonico J, Milazzo V, De Metrio M, Brambilla M, Camera M, Marenzi G
Nutrients 2021 Oct 14;13(10) doi: 10.3390/nu13103603. PMID: 34684604 Free PMC Article

Severe megaloblastic anemia: Vitamin deficiency and other causes.

Socha DS, DeSouza SI, Flagg A, Sekeres M, Rogers HJ
Cleve Clin J Med 2020 Mar;87(3):153-164. doi: 10.3949/ccjm.87a.19072. PMID: 32127439

B Vitamins and Ageing.

Mikkelsen K, Apostolopoulos V
Subcell Biochem 2018;90:451-470. doi: 10.1007/978-981-13-2835-0_15. PMID: 30779018

Polyneuropathies.

Sommer C, Geber C, Young P, Forst R, Birklein F, Schoser B
Dtsch Arztebl Int 2018 Feb 9;115(6):83-90. doi: 10.3238/arztebl.2018.083. PMID: 29478436 Free PMC Article

Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia).

Sitheeque MA, Samaranayake LP
Crit Rev Oral Biol Med 2003;14(4):253-67. doi: 10.1177/154411130301400403. PMID: 12907694

See all (371)

Prognosis

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives.

Cosentino N, Campodonico J, Milazzo V, De Metrio M, Brambilla M, Camera M, Marenzi G
Nutrients 2021 Oct 14;13(10) doi: 10.3390/nu13103603. PMID: 34684604 Free PMC Article

Appropriate and inappropriate vitamin supplementation in children.

Martini L, Pecoraro L, Salvottini C, Piacentini G, Atkinson R, Pietrobelli A
J Nutr Sci 2020 Jun 5;9:e20. doi: 10.1017/jns.2020.12. PMID: 32577225 Free PMC Article

Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.

Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490 Free PMC Article

Significance of hyperhomocysteinemia.

Herrmann W
Clin Lab 2006;52(7-8):367-74. PMID: 16955635

Vitamin neurotoxicity.

Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

See all (113)

Clinical prediction guides

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives.

Cosentino N, Campodonico J, Milazzo V, De Metrio M, Brambilla M, Camera M, Marenzi G
Nutrients 2021 Oct 14;13(10) doi: 10.3390/nu13103603. PMID: 34684604 Free PMC Article

Vitamin D3 and B12 supplementation in pregnancy.

Bhowmik B, Siddiquee T, Mdala I, Quamrun Nesa L, Jahan Shelly S, Hassan Z, Moreira NCDV, Jahan I, Azad Khan AK, Hitman GA, Hussain A
Diabetes Res Clin Pract 2021 Apr;174:108728. Epub 2021 Mar 1 doi: 10.1016/j.diabres.2021.108728. PMID: 33662489

Association between neuropathy and B-vitamins: A systematic review and meta-analysis.

Stein J, Geisel J, Obeid R
Eur J Neurol 2021 Jun;28(6):2054-2064. Epub 2021 Mar 15 doi: 10.1111/ene.14786. PMID: 33619867

Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.

Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490 Free PMC Article

Vitamin neurotoxicity.

Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

See all (182)

Recent systematic reviews

B1 Vitamin Deficiency After Bariatric Surgery, Prevalence, and Symptoms: a Systematic Review and Meta-analysis.

Bahardoust M, Eghbali F, Shahmiri SS, Alijanpour A, Yarigholi F, Valizadeh R, Madankan A, Pouraskari AB, Ashtarinezhad B, Farokhi H, Sarafraz H, Khanafshar E
Obes Surg 2022 Sep;32(9):3104-3112. Epub 2022 Jul 1 doi: 10.1007/s11695-022-06178-7. PMID: 35776243

Associations between Nutrients and Foot Ulceration in Diabetes: A Systematic Review.

Bechara N, Gunton JE, Flood V, Hng TM, McGloin C
Nutrients 2021 Jul 27;13(8) doi: 10.3390/nu13082576. PMID: 34444735 Free PMC Article

Association between neuropathy and B-vitamins: A systematic review and meta-analysis.

Stein J, Geisel J, Obeid R
Eur J Neurol 2021 Jun;28(6):2054-2064. Epub 2021 Mar 15 doi: 10.1111/ene.14786. PMID: 33619867

Iron, Vitamin B(12), Folate and Copper Deficiency After Bariatric Surgery and the Impact on Anaemia: a Systematic Review.

Lewis CA, de Jersey S, Seymour M, Hopkins G, Hickman I, Osland E
Obes Surg 2020 Nov;30(11):4542-4591. Epub 2020 Aug 12 doi: 10.1007/s11695-020-04872-y. PMID: 32785814

Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.

Fabisiak N, Fabisiak A, Watala C, Fichna J
J Clin Gastroenterol 2017 Nov/Dec;51(10):878-889. doi: 10.1097/MCG.0000000000000911. PMID: 28858940

See all (27)

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Vitamin deficiency

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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