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Borderline Fallopian Tube Mucinous Tumor

MedGen UID:
267754
•Concept ID:
C1511255
•
Neoplastic Process
Synonym: Borderline Fallopian Tube Mucinous Neoplasm

Definition

A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Fallopian Tube Mucinous Tumor

Professional guidelines

PubMed

SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.
Chapel DB, Hirsch MS
Am J Surg Pathol 2022 Feb 1;46(2):213-219. doi: 10.1097/PAS.0000000000001792. PMID: 34411029
Optimal primary management of bulky stage IIIC ovarian, fallopian tube and peritoneal carcinoma: Are the only options complete gross resection at primary debulking surgery or neoadjuvant chemotherapy?
Sioulas VD, Schiavone MB, Kadouri D, Zivanovic O, Roche KL, O'Cearbhaill R, Abu-Rustum NR, Levine DA, Sonoda Y, Gardner GJ, Leitao MM Jr, Chi DS
Gynecol Oncol 2017 Apr;145(1):15-20. Epub 2017 Feb 21 doi: 10.1016/j.ygyno.2017.02.023. PMID: 28238354Free PMC Article
Borderline and malignant mucinous tumors of the ovary. Histologic criteria and clinical behavior.
Hart WR, Norris HJ
Cancer 1973 May;31(5):1031-45. doi: 10.1002/1097-0142(197305)31:5<1031::aid-cncr2820310501>3.0.co;2-7. PMID: 4735836

Recent clinical studies

Etiology

Ovarian Metastasis by Gastric-type Endocervical Adenocarcinoma: A Clinicopathologic Description of 12 Cases.
Lu B, Shi H, Shao Y, Xu J
Int J Gynecol Pathol 2022 Jul 1;41(4):356-365. Epub 2021 Aug 4 doi: 10.1097/PGP.0000000000000815. PMID: 34347666
Alteration of BRCA-1 tumor suppressor gene expression in serous and mucinous ovarian neoplasms in the benign-borderline-malignant pathway.
Yousif HMA, Mohammed RAA
Curr Probl Cancer 2019 Aug;43(4):377-385. Epub 2018 Nov 6 doi: 10.1016/j.currproblcancer.2018.10.003. PMID: 30446260
New insights in the pathophysiology of ovarian cancer and implications for screening and prevention.
Nezhat FR, Apostol R, Nezhat C, Pejovic T
Am J Obstet Gynecol 2015 Sep;213(3):262-7. Epub 2015 Mar 25 doi: 10.1016/j.ajog.2015.03.044. PMID: 25818671
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents.
Huang M, Lv Q, Xie J
J Ovarian Res 2022 Jul 14;15(1):83. doi: 10.1186/s13048-022-01010-3. PMID: 35836292Free PMC Article
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Primary Mucinous Carcinoma of the Fallopian Tube: Case Report and Review of Literature.
Wheal A, Jenkins R, Mikami Y, Das N, Hirschowitz L
Int J Gynecol Pathol 2017 Jul;36(4):393-399. doi: 10.1097/PGP.0000000000000330. PMID: 27662036
Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis.
McCluggage WG
Pathology 2011 Aug;43(5):420-32. doi: 10.1097/PAT.0b013e328348a6e7. PMID: 21716157
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Therapy

Low grade serous ovarian cancer - A rare disease with increasing therapeutic options.
Zwimpfer TA, Tal O, Geissler F, Coelho R, Rimmer N, Jacob F, Heinzelmann-Schwarz V
Cancer Treat Rev 2023 Jan;112:102497. Epub 2022 Dec 10 doi: 10.1016/j.ctrv.2022.102497. PMID: 36525716
Mucosal Proliferations in Completely Examined Fallopian Tubes Accompanying Ovarian Low-grade Serous Tumors: Neoplastic Precursor Lesions or Normal Variants of Benign Mucosa?
Wolsky RJ, Price MA, Zaloudek CJ, Rabban JT
Int J Gynecol Pathol 2018 May;37(3):262-274. doi: 10.1097/PGP.0000000000000410. PMID: 28700429
Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube.
Soini T, Hurskainen R, Grénman S, Mäenpää J, Paavonen J, Pukkala E
Acta Oncol 2016 Nov;55(11):1281-1284. Epub 2016 May 5 doi: 10.1080/0284186X.2016.1175660. PMID: 27148621
Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.
Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Prognosis

Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents.
Huang M, Lv Q, Xie J
J Ovarian Res 2022 Jul 14;15(1):83. doi: 10.1186/s13048-022-01010-3. PMID: 35836292Free PMC Article
Alteration of BRCA-1 tumor suppressor gene expression in serous and mucinous ovarian neoplasms in the benign-borderline-malignant pathway.
Yousif HMA, Mohammed RAA
Curr Probl Cancer 2019 Aug;43(4):377-385. Epub 2018 Nov 6 doi: 10.1016/j.currproblcancer.2018.10.003. PMID: 30446260
The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications.
Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J
Arch Gynecol Obstet 2016 Apr;293(4):695-700. Epub 2016 Feb 19 doi: 10.1007/s00404-016-4035-8. PMID: 26894303
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Peritoneal carcinoma in women with genetic susceptibility: implications for Jewish populations.
Casey MJ, Bewtra C
Fam Cancer 2004;3(3-4):265-81. doi: 10.1007/s10689-004-9554-y. PMID: 15516851

Clinical prediction guides

Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.
Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773Free PMC Article
Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis.
Kim H, Lee DH, Park E, Myung JK, Park JH, Kim DI, Kim SI, Lee M, Kim Y, Park CM, Hyun CL, Maeng YH, Lee C, Jang B
Sci Rep 2022 Jul 1;12(1):11200. doi: 10.1038/s41598-022-15234-2. PMID: 35778589Free PMC Article
Precursors in the ovarian stroma: another pathway to explain the origin of ovarian serous neoplasms.
Silva EG, Lawson BC, Ramalingam P, Liu J, Shehabeldin A, Marques-Piubelli ML, Malpica A
Hum Pathol 2022 Sep;127:136-145. Epub 2022 Apr 12 doi: 10.1016/j.humpath.2022.04.008. PMID: 35427637
Alteration of BRCA-1 tumor suppressor gene expression in serous and mucinous ovarian neoplasms in the benign-borderline-malignant pathway.
Yousif HMA, Mohammed RAA
Curr Probl Cancer 2019 Aug;43(4):377-385. Epub 2018 Nov 6 doi: 10.1016/j.currproblcancer.2018.10.003. PMID: 30446260
Polypoid endometriosis: a clinicopathologic analysis of 24 cases and a review of the literature.
Parker RL, Dadmanesh F, Young RH, Clement PB
Am J Surg Pathol 2004 Mar;28(3):285-97. doi: 10.1097/00000478-200403000-00001. PMID: 15104291

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