U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Borderline Ovarian Serous Surface Papillary Tumor

MedGen UID:
267897
•Concept ID:
C1511269
•
Neoplastic Process

Definition

A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations that contain atypical serous epithelial cells in the outer surface of the ovary. There is no evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Ovarian Serous Surface Papillary Tumor

Professional guidelines

PubMed

The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors.
Cathro HP, Stoler MH
Hum Pathol 2005 Feb;36(2):195-201. doi: 10.1016/j.humpath.2004.11.011. PMID: 15754297
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
Cytopathology of serous neoplasia of the ovary and the peritoneum: differential diagnosis from mesothelial proliferations.
Pisharodi LR, Bedrossian CW
Diagn Cytopathol 1996 Nov;15(4):292-5. doi: 10.1002/(SICI)1097-0339(199611)15:4<292::AID-DC8>3.0.CO;2-G. PMID: 8982583

Recent clinical studies

Etiology

Ovarian serous surface papillary borderline tumor: characteristic imaging features with clinicopathological correlation.
Park SB, Kim MJ, Lee KH, Ko Y
Br J Radiol 2018 Jul;91(1088):20170689. Epub 2018 Jun 21 doi: 10.1259/bjr.20170689. PMID: 29888983Free PMC Article
Ovarian serous surface papillary borderline tumors form sea anemone-like masses.
Tanaka YO, Okada S, Satoh T, Matsumoto K, Oki A, Nishida M, Yoshikawa H, Saida T, Minami M
J Magn Reson Imaging 2011 Mar;33(3):633-40. Epub 2011 Feb 1 doi: 10.1002/jmri.22430. PMID: 21287653
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
Ovarian micropapillary serous borderline tumors. Clinicopathologic features and outcome of seven surgically staged patients.
Goldstein NS, Ceniza N
Am J Clin Pathol 2000 Sep;114(3):380-6. doi: 10.1093/ajcp/114.3.380. PMID: 10989638
Ovarian tumors of borderline malignancy (tumors of low malignant potential): a critical appraisal.
Prat J
Adv Anat Pathol 1999 Sep;6(5):247-74. doi: 10.1097/00125480-199909000-00002. PMID: 10472378

Diagnosis

Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Ovarian serous surface papillary borderline tumor: characteristic imaging features with clinicopathological correlation.
Park SB, Kim MJ, Lee KH, Ko Y
Br J Radiol 2018 Jul;91(1088):20170689. Epub 2018 Jun 21 doi: 10.1259/bjr.20170689. PMID: 29888983Free PMC Article
Ultrasound diagnosis of serous surface papillary borderline ovarian tumor: A case series with a review of the literature.
Ludovisi M, Foo X, Mainenti S, Testa AC, Arora R, Jurkovic D
J Clin Ultrasound 2015 Nov-Dec;43(9):573-7. Epub 2015 Feb 23 doi: 10.1002/jcu.22266. PMID: 25706035
MRI appearances of pure epithelial papillary serous borderline ovarian tumours.
Naqvi J, Nagaraju E, Ahmad S
Clin Radiol 2015 Apr;70(4):424-32. Epub 2014 Dec 13 doi: 10.1016/j.crad.2014.11.005. PMID: 25515794
Primary peritoneal serous borderline tumors.
Hutton RL, Dalton SR
Arch Pathol Lab Med 2007 Jan;131(1):138-44. doi: 10.5858/2007-131-138-PPSBT. PMID: 17227115

Therapy

Mucosal Proliferations in Completely Examined Fallopian Tubes Accompanying Ovarian Low-grade Serous Tumors: Neoplastic Precursor Lesions or Normal Variants of Benign Mucosa?
Wolsky RJ, Price MA, Zaloudek CJ, Rabban JT
Int J Gynecol Pathol 2018 May;37(3):262-274. doi: 10.1097/PGP.0000000000000410. PMID: 28700429
Evolutive peritoneal disease after conservative management and the use of infertility drugs in a patient with stage IIIC borderline micro-papillary serous carcinoma (MPSC) of the ovary: case report.
Attar E, Berkman S, Topuz S, Baysal B, Akhan S, Chambers JT
Hum Reprod 2004 Jun;19(6):1472-5. Epub 2004 Apr 22 doi: 10.1093/humrep/deh226. PMID: 15105388

Prognosis

Ovarian serous surface papillary borderline tumor: characteristic imaging features with clinicopathological correlation.
Park SB, Kim MJ, Lee KH, Ko Y
Br J Radiol 2018 Jul;91(1088):20170689. Epub 2018 Jun 21 doi: 10.1259/bjr.20170689. PMID: 29888983Free PMC Article
MRI appearances of pure epithelial papillary serous borderline ovarian tumours.
Naqvi J, Nagaraju E, Ahmad S
Clin Radiol 2015 Apr;70(4):424-32. Epub 2014 Dec 13 doi: 10.1016/j.crad.2014.11.005. PMID: 25515794
Precursors and pathogenesis of ovarian carcinoma.
Lim D, Oliva E
Pathology 2013 Apr;45(3):229-42. doi: 10.1097/PAT.0b013e32835f2264. PMID: 23478230
Ovarian serous surface papillary borderline tumors form sea anemone-like masses.
Tanaka YO, Okada S, Satoh T, Matsumoto K, Oki A, Nishida M, Yoshikawa H, Saida T, Minami M
J Magn Reson Imaging 2011 Mar;33(3):633-40. Epub 2011 Feb 1 doi: 10.1002/jmri.22430. PMID: 21287653
Borderline epithelial tumors of the ovary.
Hart WR
Mod Pathol 2005 Feb;18 Suppl 2:S33-50. doi: 10.1038/modpathol.3800307. PMID: 15761465

Clinical prediction guides

The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis.
Dehari R, Kurman RJ, Logani S, Shih IeM
Am J Surg Pathol 2007 Jul;31(7):1007-12. doi: 10.1097/PAS.0b013e31802cbbe9. PMID: 17592266
Diverse tumorigenic pathways in ovarian serous carcinoma.
Singer G, Kurman RJ, Chang HW, Cho SK, Shih IeM
Am J Pathol 2002 Apr;160(4):1223-8. doi: 10.1016/s0002-9440(10)62549-7. PMID: 11943707Free PMC Article
Ovarian papillary serous tumors of low malignant potential (serous borderline tumors). A long-term follow-up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma.
Kennedy AW, Hart WR
Cancer 1996 Jul 15;78(2):278-86. doi: 10.1002/(SICI)1097-0142(19960715)78:2<278::AID-CNCR14>3.0.CO;2-T. PMID: 8674004
Distribution of VRA09, an ovarian tumor-associated antigen, distinguishing borderline serous tumors.
Voeltzel T, Duvillard P, Ghillani P, Bénard J, Bohuon C, Bellet D, Bidart JM
Int J Cancer 1994 Oct 15;59(2):159-64. doi: 10.1002/ijc.2910590203. PMID: 7927912
On the histogenesis and morphology of ovarian carcinomas.
Dallenbach-Hellweg G
J Cancer Res Clin Oncol 1984;107(2):71-80. doi: 10.1007/BF00399375. PMID: 6715398

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...