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Breast Soft Tissue Neoplasm

MedGen UID:
267907
•Concept ID:
C1511323
•
Neoplastic Process
Synonym: Breast Soft Tissue Tumor

Definition

A benign, intermediate, or malignant mesenchymal neoplasm that arises from the breast. [from NCI]

Professional guidelines

PubMed

Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China.
Xu C, Si L, Wang W, Li Z, Song Z, Wang Q, Liu A, Yu J, Fang W, Zhong W, Wang Z, Zhang Y, Liu J, Zhang S, Cai X, Liu A, Li W, Zhan P, Liu H, Lv T, Miao L, Min L, Chen Y, Yuan J, Wang F, Jiang Z, Lin G, Pu X, Lin R, Liu W, Rao C, Lv D, Yu Z, Lei L, Li X, Tang C, Zhou C, Zhang J, Xue J, Guo H, Chu Q, Meng R, Wu J, Zhang R, Hu X, Zhou J, Zhu Z, Li Y, Qiu H, Xia F, Lu Y, Chen X, Ge R, Dai E, Han Y, Pan W, Luo J, Jia H, Dong X, Pang F, Wang K, Wang L, Zhu Y, Xie Y, Lin X, Cai J, Wei J, Lan F, Feng H, Wang L, Du Y, Yao W, Shi X, Niu X, Yuan D, Yao Y, Huang J, Zhang Y, Sun P, Wang H, Ye M, Wang D, Wang Z, Wan B, Lv D, Wei Q, Kang J, Zhang J, Zhang C, Yu G, Ou J, Shi L, Li Z, Liu Z, Liu J, Yang N, Wu L, Wang H, Jin G, Yang L, Wang G, Fang M, Fang Y, Li Y, Wang X, Zhang Y, Ma S, Wang B, Zhang X, Song Y, Lu Y
Thorac Cancer 2022 Nov;13(21):3084-3097. Epub 2022 Sep 20 doi: 10.1111/1759-7714.14644. PMID: 36127731Free PMC Article
Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Surgical Treatment of Lymphedema.
Schaverien MV, Coroneos CJ
Plast Reconstr Surg 2019 Sep;144(3):738-758. doi: 10.1097/PRS.0000000000005993. PMID: 31461041

Recent clinical studies

Etiology

The proteomic landscape of soft tissue sarcomas.
Burns J, Wilding CP, Krasny L, Zhu X, Chadha M, Tam YB, Ps H, Mahalingam AH, Lee ATJ, Arthur A, Guljar N, Perkins E, Pankova V, Jenks A, Djabatey V, Szecsei C, McCarthy F, Ragulan C, Milighetti M, Roumeliotis TI, Crosier S, Finetti M, Choudhary JS, Judson I, Fisher C, Schuster EF, Sadanandam A, Chen TW, Williamson D, Thway K, Jones RL, Cheang MCU, Huang PH
Nat Commun 2023 Jun 29;14(1):3834. doi: 10.1038/s41467-023-39486-2. PMID: 37386008Free PMC Article
Radiation-induced angiosarcoma of the breast: A review.
Bonito FJP, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R
Breast J 2020 Mar;26(3):458-463. Epub 2019 Aug 25 doi: 10.1111/tbj.13504. PMID: 31448482
Nipple-Sparing Mastectomy and Direct-to-Implant Breast Reconstruction.
Colwell AS, Christensen JM
Plast Reconstr Surg 2017 Nov;140(5S Advances in Breast Reconstruction):44S-50S. doi: 10.1097/PRS.0000000000003949. PMID: 29064921
Sarcoma of the breast: an update on a rare entity.
Lim SZ, Ong KW, Tan BK, Selvarajan S, Tan PH
J Clin Pathol 2016 May;69(5):373-81. Epub 2016 Jan 4 doi: 10.1136/jclinpath-2015-203545. PMID: 26729013
Stem cells from adipose tissue and breast cancer: hype, risks and hope.
Bertolini F, Petit JY, Kolonin MG
Br J Cancer 2015 Feb 3;112(3):419-23. Epub 2015 Jan 13 doi: 10.1038/bjc.2014.657. PMID: 25584493Free PMC Article

Diagnosis

Sarcoma care in the era of precision medicine.
Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib.
Endo M, Kataoka T, Fujiwara T, Tsukushi S, Takahashi M, Kobayashi E, Yamada Y, Tanaka T, Nezu Y, Hiraga H, Wasa J, Nagano A, Nakano K, Nakayama R, Hamada T, Kawano M, Torigoe T, Sakamoto A, Asanuma K, Morii T, Machida R, Sekino Y, Fukuda H, Oda Y, Ozaki T, Tanaka K
BMC Cancer 2023 Mar 8;23(1):219. doi: 10.1186/s12885-023-10693-w. PMID: 36890471Free PMC Article
The potential of predictive and prognostic breast MRI (P2-bMRI).
Dietzel M, Trimboli RM, Zanardo M, Schultz-Wendtland R, Uder M, Clauser P, Sardanelli F, Baltzer PAT
Eur Radiol Exp 2022 Aug 22;6(1):42. doi: 10.1186/s41747-022-00291-z. PMID: 35989400Free PMC Article
Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review.
Mujtaba B, Nassar SM, Aslam R, Garg N, Madewell JE, Taher A, Hanafy AK, Whitman G
Curr Probl Diagn Radiol 2020 Mar-Apr;49(2):116-123. Epub 2019 Jan 3 doi: 10.1067/j.cpradiol.2019.01.001. PMID: 30655112
Sarcoma of the breast: an update on a rare entity.
Lim SZ, Ong KW, Tan BK, Selvarajan S, Tan PH
J Clin Pathol 2016 May;69(5):373-81. Epub 2016 Jan 4 doi: 10.1136/jclinpath-2015-203545. PMID: 26729013

Therapy

Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy.
Choi W, Porten S, Kim S, Willis D, Plimack ER, Hoffman-Censits J, Roth B, Cheng T, Tran M, Lee IL, Melquist J, Bondaruk J, Majewski T, Zhang S, Pretzsch S, Baggerly K, Siefker-Radtke A, Czerniak B, Dinney CP, McConkey DJ
Cancer Cell 2014 Feb 10;25(2):152-65. doi: 10.1016/j.ccr.2014.01.009. PMID: 24525232Free PMC Article
Ridaforolimus.
Drugs R D 2010;10(3):165-78. doi: 10.2165/11586010-000000000-00000. PMID: 20945947Free PMC Article
Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY
J Clin Oncol 2008 Nov 10;26(32):5269-74. Epub 2008 Sep 22 doi: 10.1200/JCO.2008.17.3146. PMID: 18809609
Docetaxel.
Cortes JE, Pazdur R
J Clin Oncol 1995 Oct;13(10):2643-55. doi: 10.1200/JCO.1995.13.10.2643. PMID: 7595719
Infusion-embolization.
Wallace S, Charnsangavej C, Carrasco CH, Bechtel W
Cancer 1984 Dec 1;54(11 Suppl):2751-65. doi: 10.1002/1097-0142(19841201)54:2+<2751::aid-cncr2820541423>3.0.co;2-5. PMID: 6093984

Prognosis

Sarcoma care in the era of precision medicine.
Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
The proteomic landscape of soft tissue sarcomas.
Burns J, Wilding CP, Krasny L, Zhu X, Chadha M, Tam YB, Ps H, Mahalingam AH, Lee ATJ, Arthur A, Guljar N, Perkins E, Pankova V, Jenks A, Djabatey V, Szecsei C, McCarthy F, Ragulan C, Milighetti M, Roumeliotis TI, Crosier S, Finetti M, Choudhary JS, Judson I, Fisher C, Schuster EF, Sadanandam A, Chen TW, Williamson D, Thway K, Jones RL, Cheang MCU, Huang PH
Nat Commun 2023 Jun 29;14(1):3834. doi: 10.1038/s41467-023-39486-2. PMID: 37386008Free PMC Article
The potential of predictive and prognostic breast MRI (P2-bMRI).
Dietzel M, Trimboli RM, Zanardo M, Schultz-Wendtland R, Uder M, Clauser P, Sardanelli F, Baltzer PAT
Eur Radiol Exp 2022 Aug 22;6(1):42. doi: 10.1186/s41747-022-00291-z. PMID: 35989400Free PMC Article
Did we solve soft tissue (breast) attenuation?
Henzlova MJ, Duvall WL
J Nucl Cardiol 2021 Jun;28(3):898-900. Epub 2019 Aug 28 doi: 10.1007/s12350-019-01870-1. PMID: 31463817
Sarcoma of the breast: an update on a rare entity.
Lim SZ, Ong KW, Tan BK, Selvarajan S, Tan PH
J Clin Pathol 2016 May;69(5):373-81. Epub 2016 Jan 4 doi: 10.1136/jclinpath-2015-203545. PMID: 26729013

Clinical prediction guides

Sarcoma care in the era of precision medicine.
Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
A Role of PET/MR in Breast Cancer?
Bruckmann NM, Morawitz J, Fendler WP, Ruckhäberle E, Bittner AK, Giesel FL, Herrmann K, Antoch G, Umutlu L, Kirchner J
Semin Nucl Med 2022 Sep;52(5):611-618. Epub 2022 Mar 5 doi: 10.1053/j.semnuclmed.2022.01.003. PMID: 35260243
Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy.
Choi W, Porten S, Kim S, Willis D, Plimack ER, Hoffman-Censits J, Roth B, Cheng T, Tran M, Lee IL, Melquist J, Bondaruk J, Majewski T, Zhang S, Pretzsch S, Baggerly K, Siefker-Radtke A, Czerniak B, Dinney CP, McConkey DJ
Cancer Cell 2014 Feb 10;25(2):152-65. doi: 10.1016/j.ccr.2014.01.009. PMID: 24525232Free PMC Article
Angiosarcoma.
Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ
Lancet Oncol 2010 Oct;11(10):983-91. Epub 2010 May 25 doi: 10.1016/S1470-2045(10)70023-1. PMID: 20537949
Metallothioneins and cancer.
Eckschlager T, Adam V, Hrabeta J, Figova K, Kizek R
Curr Protein Pept Sci 2009 Aug;10(4):360-75. doi: 10.2174/138920309788922243. PMID: 19689357

Recent systematic reviews

Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies.
Cupp MA, Cariolou M, Tzoulaki I, Aune D, Evangelou E, Berlanga-Taylor AJ
BMC Med 2020 Nov 20;18(1):360. doi: 10.1186/s12916-020-01817-1. PMID: 33213430Free PMC Article
The role of pazopanib on tumour angiogenesis and in the management of cancers: A review.
Chellappan DK, Chellian J, Ng ZY, Sim YJ, Theng CW, Ling J, Wong M, Foo JH, Yang GJ, Hang LY, Nathan S, Singh Y, Gupta G
Biomed Pharmacother 2017 Dec;96:768-781. Epub 2017 Nov 6 doi: 10.1016/j.biopha.2017.10.058. PMID: 29054093
Systemic antibiotics for treating malignant wounds.
Ramasubbu DA, Smith V, Hayden F, Cronin P
Cochrane Database Syst Rev 2017 Aug 24;8(8):CD011609. doi: 10.1002/14651858.CD011609.pub2. PMID: 28837757Free PMC Article
A systematic overview of radiation therapy effects in soft tissue sarcomas.
Strander H, Turesson I, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):516-31. doi: 10.1080/02841860310014732. PMID: 14596510

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