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Hematopoietic and lymphoid system neoplasm

MedGen UID:
268180
Concept ID:
C1512393
Neoplastic Process
Synonyms: blood neoplasm (disease); blood tumor; blood tumour; haematological tumours; haematopoietic and lymphoid system tumour; haematopoietic system neoplasm; haematopoietic system tumour; haematopoietic tumours; hematologic cancer; hematological tumors; Hematopoietic and Lymphoid System Neoplasm; hematopoietic and lymphoid system neoplasm; Hematopoietic and Lymphoid System Tumor; hematopoietic and lymphoid system tumor; hematopoietic system neoplasm; hematopoietic system tumor; hematopoietic tumors; malignant haematopoietic neoplasm; neoplasm of blood; neoplasm of haematopoietic system; neoplasm of hematopoietic system; tumor of blood; tumor of hematopoietic system; tumour of blood; tumour of haematopoietic system
 
Monarch Initiative: MONDO:0002334

Definition

Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHematopoietic and lymphoid system neoplasm

Professional guidelines

PubMed

Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Deshantri AK, Varela Moreira A, Ecker V, Mandhane SN, Schiffelers RM, Buchner M, Fens MHAM
J Control Release 2018 Oct 10;287:194-215. Epub 2018 Aug 28 doi: 10.1016/j.jconrel.2018.08.034. PMID: 30165140
Ansell SM
Mayo Clin Proc 2015 Aug;90(8):1152-63. doi: 10.1016/j.mayocp.2015.04.025. PMID: 26250731

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Recent clinical studies

Etiology

Montefiori LE, Bendig S, Gu Z, Chen X, Pölönen P, Ma X, Murison A, Zeng A, Garcia-Prat L, Dickerson K, Iacobucci I, Abdelhamed S, Hiltenbrand R, Mead PE, Mehr CM, Xu B, Cheng Z, Chang TC, Westover T, Ma J, Stengel A, Kimura S, Qu C, Valentine MB, Rashkovan M, Luger S, Litzow MR, Rowe JM, den Boer ML, Wang V, Yin J, Kornblau SM, Hunger SP, Loh ML, Pui CH, Yang W, Crews KR, Roberts KG, Yang JJ, Relling MV, Evans WE, Stock W, Paietta EM, Ferrando AA, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG
Cancer Discov 2021 Nov;11(11):2846-2867. Epub 2021 Jun 8 doi: 10.1158/2159-8290.CD-21-0145. PMID: 34103329Free PMC Article
Pollard JA, Guest E, Alonzo TA, Gerbing RB, Loken MR, Brodersen LE, Kolb EA, Aplenc R, Meshinchi S, Raimondi SC, Hirsch B, Gamis AS
J Clin Oncol 2021 Oct 1;39(28):3149-3160. Epub 2021 May 28 doi: 10.1200/JCO.20.03048. PMID: 34048275Free PMC Article
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Gianelli U, Thiele J, Orazi A, Gangat N, Vannucchi AM, Tefferi A, Kvasnicka HM
Virchows Arch 2023 Jan;482(1):53-68. Epub 2022 Dec 29 doi: 10.1007/s00428-022-03480-8. PMID: 36580136Free PMC Article
Campo E, Jaffe ES, Cook JR, Quintanilla-Martinez L, Swerdlow SH, Anderson KC, Brousset P, Cerroni L, de Leval L, Dirnhofer S, Dogan A, Feldman AL, Fend F, Friedberg JW, Gaulard P, Ghia P, Horwitz SM, King RL, Salles G, San-Miguel J, Seymour JF, Treon SP, Vose JM, Zucca E, Advani R, Ansell S, Au WY, Barrionuevo C, Bergsagel L, Chan WC, Cohen JI, d'Amore F, Davies A, Falini B, Ghobrial IM, Goodlad JR, Gribben JG, Hsi ED, Kahl BS, Kim WS, Kumar S, LaCasce AS, Laurent C, Lenz G, Leonard JP, Link MP, Lopez-Guillermo A, Mateos MV, Macintyre E, Melnick AM, Morschhauser F, Nakamura S, Narbaitz M, Pavlovsky A, Pileri SA, Piris M, Pro B, Rajkumar V, Rosen ST, Sander B, Sehn L, Shipp MA, Smith SM, Staudt LM, Thieblemont C, Tousseyn T, Wilson WH, Yoshino T, Zinzani PL, Dreyling M, Scott DW, Winter JN, Zelenetz AD
Blood 2022 Sep 15;140(11):1229-1253. doi: 10.1182/blood.2022015851. PMID: 35653592Free PMC Article
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Ansell SM
Mayo Clin Proc 2015 Aug;90(8):1152-63. doi: 10.1016/j.mayocp.2015.04.025. PMID: 26250731

Therapy

Mempel TR, Lill JK, Altenburger LM
Nat Rev Cancer 2024 Jan;24(1):28-50. Epub 2023 Dec 8 doi: 10.1038/s41568-023-00635-w. PMID: 38066335
Calimeri T, Steffanoni S, Gagliardi F, Chiara A, Ferreri AJM
ESMO Open 2021 Aug;6(4):100213. Epub 2021 Jul 13 doi: 10.1016/j.esmoop.2021.100213. PMID: 34271311Free PMC Article
Horwitz ME, Stiff PJ, Cutler C, Brunstein C, Hanna R, Maziarz RT, Rezvani AR, Karris NA, McGuirk J, Valcarcel D, Schiller GJ, Lindemans CA, Hwang WYK, Koh LP, Keating A, Khaled Y, Hamerschlak N, Frankfurt O, Peled T, Segalovich I, Blackwell B, Wease S, Freedman LS, Galamidi-Cohen E, Sanz G
Blood 2021 Oct 21;138(16):1429-1440. doi: 10.1182/blood.2021011719. PMID: 34157093Free PMC Article
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Bronte V, Pittet MJ
Immunity 2013 Nov 14;39(5):806-18. doi: 10.1016/j.immuni.2013.10.010. PMID: 24238338Free PMC Article

Prognosis

Gianelli U, Thiele J, Orazi A, Gangat N, Vannucchi AM, Tefferi A, Kvasnicka HM
Virchows Arch 2023 Jan;482(1):53-68. Epub 2022 Dec 29 doi: 10.1007/s00428-022-03480-8. PMID: 36580136Free PMC Article
Yi S, Yan Y, Jin M, Bhattacharya S, Wang Y, Wu Y, Yang L, Gine E, Clot G, Chen L, Yu Y, Zou D, Wang J, Phan AT, Cui R, Li F, Sun Q, Zhai Q, Wang T, Yu Z, Liu L, Liu W, Lyv R, Sui W, Huang W, Xiong W, Wang H, Li C, Xiao Z, Hao M, Wang J, Cheng T, Bea S, Herrera AF, Danilov A, Campo E, Ngo VN, Qiu L, Wang L
J Clin Invest 2022 Feb 1;132(3) doi: 10.1172/JCI153283. PMID: 34882582Free PMC Article
Locke FL, Ghobadi A, Jacobson CA, Miklos DB, Lekakis LJ, Oluwole OO, Lin Y, Braunschweig I, Hill BT, Timmerman JM, Deol A, Reagan PM, Stiff P, Flinn IW, Farooq U, Goy A, McSweeney PA, Munoz J, Siddiqi T, Chavez JC, Herrera AF, Bartlett NL, Wiezorek JS, Navale L, Xue A, Jiang Y, Bot A, Rossi JM, Kim JJ, Go WY, Neelapu SS
Lancet Oncol 2019 Jan;20(1):31-42. Epub 2018 Dec 2 doi: 10.1016/S1470-2045(18)30864-7. PMID: 30518502Free PMC Article
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Ansell SM
Mayo Clin Proc 2015 Aug;90(8):1152-63. doi: 10.1016/j.mayocp.2015.04.025. PMID: 26250731

Clinical prediction guides

Mempel TR, Lill JK, Altenburger LM
Nat Rev Cancer 2024 Jan;24(1):28-50. Epub 2023 Dec 8 doi: 10.1038/s41568-023-00635-w. PMID: 38066335
Frigault MJ, Dietrich J, Gallagher K, Roschewski M, Jordan JT, Forst D, Plotkin SR, Cook D, Casey KS, Lindell KA, Depinho GD, Katsis K, Elder EL, Leick MB, Choi B, Horick N, Preffer F, Saylor M, McAfee S, O'Donnell PV, Spitzer TR, Dey B, DeFilipp Z, El-Jawahri A, Batchelor TT, Maus MV, Chen YB
Blood 2022 Apr 14;139(15):2306-2315. doi: 10.1182/blood.2021014738. PMID: 35167655Free PMC Article
Pollard JA, Guest E, Alonzo TA, Gerbing RB, Loken MR, Brodersen LE, Kolb EA, Aplenc R, Meshinchi S, Raimondi SC, Hirsch B, Gamis AS
J Clin Oncol 2021 Oct 1;39(28):3149-3160. Epub 2021 May 28 doi: 10.1200/JCO.20.03048. PMID: 34048275Free PMC Article
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Gualco G, Weiss LM, Bacchi CE
Appl Immunohistochem Mol Morphol 2010 Jul;18(4):301-10. doi: 10.1097/PAI.0b013e3181cf1126. PMID: 20182347

Recent systematic reviews

Abdellatif M, Tawfik GM, Makram AM, Abdelsattar MK, Dobs M, Papadopoulos DN, Hoang-Trong BL, Mostafa EM, Duong PDT, Huy NT
Eur J Pediatr 2023 Jan;182(1):329-341. Epub 2022 Nov 10 doi: 10.1007/s00431-022-04675-6. PMID: 36352244

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    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

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