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Impaired Cell Membrane Integrity

MedGen UID:
268257
•Concept ID:
C1512680
•
Cell or Molecular Dysfunction

Definition

Impaired Cell Membrane Integrity consists of activities that interfere with, or restrain, fabrication, construction, or maintenance of the regular structure and function of semipermeable lipid bilayer membranes that surround or reside within a cell. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired Cell Membrane Integrity

Professional guidelines

PubMed

Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review.
Zhang L, Zhang W, Li Z, Lin S, Zheng T, Hao B, Hou Y, Zhang Y, Wang K, Qin C, Yue L, Jin J, Li M, Fan L
J Exp Clin Cancer Res 2022 Jul 21;41(1):227. doi: 10.1186/s13046-022-02439-6. PMID: 35864520Free PMC Article
Empowering Muscle Stem Cells for the Treatment of Duchenne Muscular Dystrophy.
Filippelli RL, Chang NC
Cells Tissues Organs 2022;211(6):641-654. Epub 2021 Apr 28 doi: 10.1159/000514305. PMID: 33910206
Management of conjunctival cicatrizing diseases and severe ocular surface dysfunction.
Chiou AG, Florakis GJ, Kazim M
Surv Ophthalmol 1998 Jul-Aug;43(1):19-46. doi: 10.1016/s0039-6257(98)00005-8. PMID: 9716191

Recent clinical studies

Etiology

Frailty Syndrome: Visceral Adipose Tissue and Frailty in Patients with Symptomatic Severe Aortic Stenosis.
Pinheiro M, Mancio J, Conceição G, Ferreira W, Carvalho M, Santos A, Vouga L, Gama Ribeiro V, Leite-Moreira A, Falcão-Pires I, Bettencourt N
J Nutr Health Aging 2017;21(1):120-128. doi: 10.1007/s12603-016-0795-x. PMID: 27999858

Prognosis

Critical illness with hyponatraemia and impaired cell membrane integrity--the "sick cell syndrome" revisited.
Gill GV, Osypiw JC, Shearer E, English PJ, Watson ID
Clin Biochem 2005 Nov;38(11):1045-8. Epub 2005 Aug 25 doi: 10.1016/j.clinbiochem.2005.07.014. PMID: 16125161

Clinical prediction guides

Differential immunomodulating effects of pegylated liposomal doxorubicin nanoparticles on human macrophages.
Liu CY, Tsai TH, Huang YC, Shieh HR, Liao HF, Chen YJ
J Nanosci Nanotechnol 2012 Oct;12(10):7739-46. doi: 10.1166/jnn.2012.6644. PMID: 23421135

Supplemental Content

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    • PMC Articles
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