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High Grade Endometrial Endometrioid Adenocarcinoma

MedGen UID:
268462
Concept ID:
C1512255
Neoplastic Process
Synonyms: FIGO Grade 3 Endometrial Endometrioid Adenocarcinoma; High Grade Endometrial Endometrioid Carcinoma; High-Grade Endometrial Endometrioid Adenocarcinoma; High-Grade Endometrial Endometrioid Carcinoma

Definition

Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Endometrial Endometrioid Adenocarcinoma

Professional guidelines

PubMed

Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Kilts TP, Glaser GE, Langstraat CL, Kumar A, Weaver AL, Mc Gree ME, Gostout BS, Podratz KC, Dowdy SC, Cliby WA, Mariani A, Bakkum-Gamez JN
Gynecol Oncol 2019 Oct;155(1):21-26. Epub 2019 Aug 10 doi: 10.1016/j.ygyno.2019.08.005. PMID: 31409487
Stelloo E, Nout RA, Osse EM, Jürgenliemk-Schulz IJ, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Nijman HW, Putter H, Bosse T, Creutzberg CL, Smit VT
Clin Cancer Res 2016 Aug 15;22(16):4215-24. Epub 2016 Mar 22 doi: 10.1158/1078-0432.CCR-15-2878. PMID: 27006490

Recent clinical studies

Etiology

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, Haie-Meder C, Ottevanger PB, Ledermann JA, Khaw P, Colombo A, Fyles A, Baron MH, Jürgenliemk-Schulz IM, Kitchener HC, Nijman HW, Wilson G, Brooks S, Carinelli S, Provencher D, Hanzen C, Lutgens LCHW, Smit VTHBM, Singh N, Do V, D'Amico R, Nout RA, Feeney A, Verhoeven-Adema KW, Putter H, Creutzberg CL; PORTEC study group
Lancet Oncol 2018 Mar;19(3):295-309. Epub 2018 Feb 12 doi: 10.1016/S1470-2045(18)30079-2. PMID: 29449189Free PMC Article

Diagnosis

Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi: 10.1097/PGP.0000000000000491. PMID: 30550483Free PMC Article
Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Therapy

Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, Haie-Meder C, Ottevanger PB, Ledermann JA, Khaw P, Colombo A, Fyles A, Baron MH, Jürgenliemk-Schulz IM, Kitchener HC, Nijman HW, Wilson G, Brooks S, Carinelli S, Provencher D, Hanzen C, Lutgens LCHW, Smit VTHBM, Singh N, Do V, D'Amico R, Nout RA, Feeney A, Verhoeven-Adema KW, Putter H, Creutzberg CL; PORTEC study group
Lancet Oncol 2018 Mar;19(3):295-309. Epub 2018 Feb 12 doi: 10.1016/S1470-2045(18)30079-2. PMID: 29449189Free PMC Article
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Prognosis

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563
de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, Haie-Meder C, Ottevanger PB, Ledermann JA, Khaw P, Colombo A, Fyles A, Baron MH, Jürgenliemk-Schulz IM, Kitchener HC, Nijman HW, Wilson G, Brooks S, Carinelli S, Provencher D, Hanzen C, Lutgens LCHW, Smit VTHBM, Singh N, Do V, D'Amico R, Nout RA, Feeney A, Verhoeven-Adema KW, Putter H, Creutzberg CL; PORTEC study group
Lancet Oncol 2018 Mar;19(3):295-309. Epub 2018 Feb 12 doi: 10.1016/S1470-2045(18)30079-2. PMID: 29449189Free PMC Article

Clinical prediction guides

Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Nakamura M, Obata T, Daikoku T, Fujiwara H
Int J Mol Sci 2019 Nov 4;20(21) doi: 10.3390/ijms20215482. PMID: 31689961Free PMC Article
Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563

Recent systematic reviews

Giampaolino P, Cafasso V, Boccia D, Ascione M, Mercorio A, Viciglione F, Palumbo M, Serafino P, Buonfantino C, De Angelis MC, Verrazzo P, Grasso G, Gullo G, Bifulco G, Della Corte L
Biomed Res Int 2022;2022:4070368. Epub 2022 Sep 27 doi: 10.1155/2022/4070368. PMID: 36203482Free PMC Article
Kim NR, Lee AJ, Yang EJ, So KA, Lee SJ, Kim TJ, Shim SH
Gynecol Oncol 2022 Aug;166(2):236-244. Epub 2022 Jun 17 doi: 10.1016/j.ygyno.2022.06.004. PMID: 35725657
Jumaah AS, Al-Haddad HS, McAllister KA, Yasseen AA
PLoS One 2022;17(2):e0263585. Epub 2022 Feb 9 doi: 10.1371/journal.pone.0263585. PMID: 35139130Free PMC Article
Liang X, Zeng H, Chen S, Jiang M, Liu S, Fan J
Eur J Obstet Gynecol Reprod Biol 2021 Dec;267:245-255. Epub 2021 Nov 13 doi: 10.1016/j.ejogrb.2021.11.016. PMID: 34837854
Palomba S, Falbo A, Russo T, La Sala GB
J Minim Invasive Gynecol 2012 Jul-Aug;19(4):531-7. doi: 10.1016/j.jmig.2012.03.023. PMID: 22748961

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