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Mature Ganglioneuroma

MedGen UID:
268638
•Concept ID:
C1513025
•
Neoplastic Process

Definition

A ganglioneuroma characterized by the presence of mature ganglion cells and a mature Schwannian stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMature Ganglioneuroma

Professional guidelines

PubMed

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Neuroblastoma: current drug therapy recommendations as part of the total treatment approach.
Berthold F, Hero B
Drugs 2000 Jun;59(6):1261-77. doi: 10.2165/00003495-200059060-00006. PMID: 10882162
Diagnosis and follow-up of neuroblastoma by means of iodine-123 metaiodobenzylguanidine scintigraphy and bone scan, and the influence of histology.
Hadj-Djilani NL, Lebtahi NE, Delaloye AB, Laurini R, Beck D
Eur J Nucl Med 1995 Apr;22(4):322-9. doi: 10.1007/BF00941848. PMID: 7607262

Recent clinical studies

Etiology

Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.
Berthold F, Rosswog C, Christiansen H, Frühwald M, Hemstedt N, Klingebiel T, Fröhlich B, Schilling FH, Schmid I, Simon T, Hero B, Fischer M, Ernst A
Pediatr Blood Cancer 2021 Aug;68(8):e29038. Epub 2021 Apr 7 doi: 10.1002/pbc.29038. PMID: 33826231
Rapid-onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation and neuroendocrine tumor syndrome with a homogenous enlargement of the pituitary gland: a case report.
Aljabban L, Kassab L, Bakoura NA, Alsalka MF, Maksoud I
J Med Case Rep 2016 Nov 22;10(1):328. doi: 10.1186/s13256-016-1116-z. PMID: 27876089Free PMC Article
Induction of neuroblastoma maturation by a new chemotherapy protocol.
Raaf JH, Cangir A, Luna M
Med Pediatr Oncol 1982;10(3):275-82. doi: 10.1002/mpo.2950100308. PMID: 7087896

Diagnosis

Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.
Berthold F, Rosswog C, Christiansen H, Frühwald M, Hemstedt N, Klingebiel T, Fröhlich B, Schilling FH, Schmid I, Simon T, Hero B, Fischer M, Ernst A
Pediatr Blood Cancer 2021 Aug;68(8):e29038. Epub 2021 Apr 7 doi: 10.1002/pbc.29038. PMID: 33826231
Rapid-onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation and neuroendocrine tumor syndrome with a homogenous enlargement of the pituitary gland: a case report.
Aljabban L, Kassab L, Bakoura NA, Alsalka MF, Maksoud I
J Med Case Rep 2016 Nov 22;10(1):328. doi: 10.1186/s13256-016-1116-z. PMID: 27876089Free PMC Article
Coexistence of renal cell carcinoma of clear cell type with sarcomatoid cell type component and adrenal mature ganglioneuroma with myelolipoma - a case of 69-year-old female patient.
Lewitowicz P, Wincewicz A, Horecka-Lewitowicz A, Matykiewicz J, Kozieł D, Głuszek S, Sulkowski S
Rom J Morphol Embryol 2014;55(2):425-32. PMID: 24969996
A case of ganglioneuroma presenting abnormal FDG uptake.
Miyake M, Tateishi U, Maeda T, Arai Y, Seki K, Hasegawa T, Sugimura K
Ann Nucl Med 2006 Jun;20(5):357-60. doi: 10.1007/BF02987247. PMID: 16878708
Urinary excretion of methylated catecholamine metabolites in a child with neuroblastoma maturing into ganglioneuroma.
Candito M, Soler C, Deville A, Bekri S, Chambon P, Thyss A
Med Pediatr Oncol 1996 Jan;26(1):57-60. doi: 10.1002/(SICI)1096-911X(199601)26:1<57::AID-MPO8>3.0.CO;2-U. PMID: 7494513

Therapy

Olfactory neuroblastoma with epithelial and endocrine differentiation transformed into ganglioneuroma after chemoradiotherapy.
Miura K, Mineta H, Yokota N, Tsutsui Y
Pathol Int 2001 Dec;51(12):942-7. doi: 10.1046/j.1440-1827.2001.01300.x. PMID: 11844067
Induction of neuroblastoma maturation by a new chemotherapy protocol.
Raaf JH, Cangir A, Luna M
Med Pediatr Oncol 1982;10(3):275-82. doi: 10.1002/mpo.2950100308. PMID: 7087896

Prognosis

Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.
Berthold F, Rosswog C, Christiansen H, Frühwald M, Hemstedt N, Klingebiel T, Fröhlich B, Schilling FH, Schmid I, Simon T, Hero B, Fischer M, Ernst A
Pediatr Blood Cancer 2021 Aug;68(8):e29038. Epub 2021 Apr 7 doi: 10.1002/pbc.29038. PMID: 33826231
Rapid-onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation and neuroendocrine tumor syndrome with a homogenous enlargement of the pituitary gland: a case report.
Aljabban L, Kassab L, Bakoura NA, Alsalka MF, Maksoud I
J Med Case Rep 2016 Nov 22;10(1):328. doi: 10.1186/s13256-016-1116-z. PMID: 27876089Free PMC Article
Olfactory neuroblastoma with epithelial and endocrine differentiation transformed into ganglioneuroma after chemoradiotherapy.
Miura K, Mineta H, Yokota N, Tsutsui Y
Pathol Int 2001 Dec;51(12):942-7. doi: 10.1046/j.1440-1827.2001.01300.x. PMID: 11844067
Urinary excretion of methylated catecholamine metabolites in a child with neuroblastoma maturing into ganglioneuroma.
Candito M, Soler C, Deville A, Bekri S, Chambon P, Thyss A
Med Pediatr Oncol 1996 Jan;26(1):57-60. doi: 10.1002/(SICI)1096-911X(199601)26:1<57::AID-MPO8>3.0.CO;2-U. PMID: 7494513
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases.
Sirinelli D, Silberman B, Baudon JJ, Sinnassamy P, Gruner M, Montagne JP
Pediatr Radiol 1989;19(4):242-5. doi: 10.1007/BF02386843. PMID: 2748231

Clinical prediction guides

Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.
Berthold F, Rosswog C, Christiansen H, Frühwald M, Hemstedt N, Klingebiel T, Fröhlich B, Schilling FH, Schmid I, Simon T, Hero B, Fischer M, Ernst A
Pediatr Blood Cancer 2021 Aug;68(8):e29038. Epub 2021 Apr 7 doi: 10.1002/pbc.29038. PMID: 33826231
Rapid-onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation and neuroendocrine tumor syndrome with a homogenous enlargement of the pituitary gland: a case report.
Aljabban L, Kassab L, Bakoura NA, Alsalka MF, Maksoud I
J Med Case Rep 2016 Nov 22;10(1):328. doi: 10.1186/s13256-016-1116-z. PMID: 27876089Free PMC Article
In vitro antigenic modulation of human neuroblastoma cells induced by IFN-gamma, retinoic acid and dibutyryl cyclic AMP.
Gross N, Beck D, Favre S, Carrel S
Int J Cancer 1987 Apr 15;39(4):521-9. doi: 10.1002/ijc.2910390420. PMID: 3030944

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