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Penis mixed squamous cell carcinoma

MedGen UID:
268711
•Concept ID:
C1513369
•
Neoplastic Process
Synonyms: Mixed Squamous Cell Carcinoma of the Penis; mixed squamous cell carcinoma of the penis; Penile Mixed Squamous Cell Carcinoma; penis mixed squamous cell carcinoma
 
Monarch Initiative: MONDO:0004430

Definition

A squamous cell carcinoma that arises from the penis and is characterized by a mixture of morphologic patterns (e.g., high grade squamous cell carcinoma and verrucous carcinoma or warty-basaloid carcinoma). [from NCI]

Professional guidelines

PubMed

Surgical treatment of female urethral carcinoma.
Narayan P, Konety B
Urol Clin North Am 1992 May;19(2):373-82. PMID: 1574827

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma.
Renaud-Vilmer C, Cavelier-Balloy B, Verola O, Morel P, Servant JM, Desgrandchamps F, Dubertret L
J Am Acad Dermatol 2010 Feb;62(2):284-90. doi: 10.1016/j.jaad.2009.06.087. PMID: 20115951
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol 2009 Sep;22(9):1160-8. Epub 2009 May 22 doi: 10.1038/modpathol.2009.77. PMID: 19465901
Clinical and sonographic findings in carcinoma of the penis.
Agrawal A, Pai D, Ananthakrishnan N, Smile SR, Ratnakar C
J Clin Ultrasound 2000 Oct;28(8):399-406. doi: 10.1002/1097-0096(200010)28:8<399::aid-jcu4>3.0.co;2-j. PMID: 10993967

Diagnosis

p53 and p16(ink4a) As Predictive and Prognostic Biomarkers for Nodal metastasis and Survival in A Contemporary Cohort of Penile Squamous Cell Carcinoma.
Mohanty SK, Mishra SK, Bhardwaj N, Sardana R, Jaiswal S, Pattnaik N, Pradhan D, Sharma S, Kaushal S, Baisakh MR, Das S, Pradhan MR, Satapathy K, Pattnaik A, Sharma SK, Khadenga CR, Das S, Rath D, Nanda B, Parwani AV
Clin Genitourin Cancer 2021 Dec;19(6):510-520. Epub 2021 Jul 10 doi: 10.1016/j.clgc.2021.07.001. PMID: 34348854
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol 2009 Sep;22(9):1160-8. Epub 2009 May 22 doi: 10.1038/modpathol.2009.77. PMID: 19465901
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626
Clinical and sonographic findings in carcinoma of the penis.
Agrawal A, Pai D, Ananthakrishnan N, Smile SR, Ratnakar C
J Clin Ultrasound 2000 Oct;28(8):399-406. doi: 10.1002/1097-0096(200010)28:8<399::aid-jcu4>3.0.co;2-j. PMID: 10993967

Therapy

Verrucous carcinoma of the renal pelvis with a focus of conventional squamous cell carcinoma.
Baseskioğlu B, Yenilmez A, Acıkalın M, Can C, Dönmez T
Urol Int 2012;88(1):115-7. Epub 2011 Sep 28 doi: 10.1159/000330906. PMID: 21968520
Clinical and sonographic findings in carcinoma of the penis.
Agrawal A, Pai D, Ananthakrishnan N, Smile SR, Ratnakar C
J Clin Ultrasound 2000 Oct;28(8):399-406. doi: 10.1002/1097-0096(200010)28:8<399::aid-jcu4>3.0.co;2-j. PMID: 10993967

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
p53 and p16(ink4a) As Predictive and Prognostic Biomarkers for Nodal metastasis and Survival in A Contemporary Cohort of Penile Squamous Cell Carcinoma.
Mohanty SK, Mishra SK, Bhardwaj N, Sardana R, Jaiswal S, Pattnaik N, Pradhan D, Sharma S, Kaushal S, Baisakh MR, Das S, Pradhan MR, Satapathy K, Pattnaik A, Sharma SK, Khadenga CR, Das S, Rath D, Nanda B, Parwani AV
Clin Genitourin Cancer 2021 Dec;19(6):510-520. Epub 2021 Jul 10 doi: 10.1016/j.clgc.2021.07.001. PMID: 34348854
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626
Primary carcinoma of male urethra.
Hopkins SC, Nag SK, Soloway MS
Urology 1984 Feb;23(2):128-33. doi: 10.1016/0090-4295(84)90005-0. PMID: 6538052

Clinical prediction guides

p53 and p16(ink4a) As Predictive and Prognostic Biomarkers for Nodal metastasis and Survival in A Contemporary Cohort of Penile Squamous Cell Carcinoma.
Mohanty SK, Mishra SK, Bhardwaj N, Sardana R, Jaiswal S, Pattnaik N, Pradhan D, Sharma S, Kaushal S, Baisakh MR, Das S, Pradhan MR, Satapathy K, Pattnaik A, Sharma SK, Khadenga CR, Das S, Rath D, Nanda B, Parwani AV
Clin Genitourin Cancer 2021 Dec;19(6):510-520. Epub 2021 Jul 10 doi: 10.1016/j.clgc.2021.07.001. PMID: 34348854
Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma.
Renaud-Vilmer C, Cavelier-Balloy B, Verola O, Morel P, Servant JM, Desgrandchamps F, Dubertret L
J Am Acad Dermatol 2010 Feb;62(2):284-90. doi: 10.1016/j.jaad.2009.06.087. PMID: 20115951
Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases.
Chaux A, Reuter V, Lezcano C, Velazquez EF, Torres J, Cubilla AL
Am J Surg Pathol 2009 Sep;33(9):1299-306. doi: 10.1097/PAS.0b013e3181a418ae. PMID: 19471153
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol 2009 Sep;22(9):1160-8. Epub 2009 May 22 doi: 10.1038/modpathol.2009.77. PMID: 19465901

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