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Double Minutes

MedGen UID:: 268759
•Concept ID:: C1512047
•: Cell or Molecular Dysfunction

Synonym:

Double Minute Chromosome

Definition

An extrachromosomal circular DNA located in the nucleus that is relatively small in size and contains chromatin but lacks a centromere and telomeres. These circular DNAs are found in tumor cells and are able to replicate during cell division during chromosome replication. They often contain extra copies of oncogenes and/or genes involved in drug resistance and lack transcription regulatory elements. Unregulated expression of genes present in these structures may play a role in tumor growth and tumor cell survival. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDouble Minutes

Molecular Abnormality
- Cytogenetic Abnormality
  - Double Minutes

Professional guidelines

PubMed

Cytotoxic and genotoxic effects of (131) I and (60) Co in follicular thyroid cancer cell (WRO) with and without recombinant human thyroid-stimulating hormone treatment.

Valgôde FGS, da Silva MA, Vieira DP, Ribela MTCP, Bartolini P, Okazaki K
Environ Mol Mutagen 2017 Jul;58(6):451-461. Epub 2017 May 31 doi: 10.1002/em.22099. PMID: 28561379

Screening by fluorescence in situ hybridization for MLL status at diagnosis in 239 unselected patients with acute myeloblastic leukemia.

Arnaud B, Douet-Guilbert N, Morel F, Le Bris MJ, Herry A, Banzakour S, Bourquard P, Morice P, Le Calvez G, Marion V, Abgrall JF, Berthou C, De Braekeleer M
Cancer Genet Cytogenet 2005 Sep;161(2):110-5. doi: 10.1016/j.cancergencyto.2005.02.012. PMID: 16102580

See all (2)

Recent clinical studies

Etiology

Cytogenomic characterization of double minute heterogeneity in therapy related acute myeloid leukemia.

Koduru P, Chen W, Haley B, Ho K, Oliver D, Wilson K
Cancer Genet 2019 Oct;238:69-75. Epub 2019 Aug 6 doi: 10.1016/j.cancergen.2019.08.001. PMID: 31425928

NPM1 deletion is associated with gross chromosomal rearrangements in leukemia.

La Starza R, Matteucci C, Gorello P, Brandimarte L, Pierini V, Crescenzi B, Nofrini V, Rosati R, Gottardi E, Saglio G, Santucci A, Berchicci L, Arcioni F, Falini B, Martelli MF, Sambani C, Aventin A, Mecucci C
PLoS One 2010 Sep 21;5(9):e12855. doi: 10.1371/journal.pone.0012855. PMID: 20877721 Free PMC Article

Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors.

Del Rey J, Prat E, Ponsa I, Lloreta J, Gelabert A, Algaba F, Camps J, Miró R
BMC Cancer 2010 Jun 11;10:280. doi: 10.1186/1471-2407-10-280. PMID: 20540739 Free PMC Article

Oncogene amplification in solid tumors.

Schwab M
Semin Cancer Biol 1999 Aug;9(4):319-25. doi: 10.1006/scbi.1999.0126. PMID: 10448118

Double minutes in acute myeloid leukemia.

Li YS
Int J Cancer 1983 Oct 15;32(4):455-9. doi: 10.1002/ijc.2910320411. PMID: 6352519

See all (30)

Diagnosis

Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges.

Song K, Minami JK, Huang A, Dehkordi SR, Lomeli SH, Luebeck J, Goodman MH, Moriceau G, Krijgsman O, Dharanipragada P, Ridgley T, Crosson WP, Salazar J, Pazol E, Karin G, Jayaraman R, Balanis NG, Alhani S, Sheu K, Ten Hoeve J, Palermo A, Motika SE, Senaratne TN, Paraiso KH, Hergenrother PJ, Rao PN, Multani AS, Peeper DS, Bafna V, Lo RS, Graeber TG
Cancer Discov 2022 Apr 1;12(4):1046-1069. doi: 10.1158/2159-8290.CD-20-0936. PMID: 34930786 Free PMC Article

Structure and evolution of double minutes in diagnosis and relapse brain tumors.

Xu K, Ding L, Chang TC, Shao Y, Chiang J, Mulder H, Wang S, Shaw TI, Wen J, Hover L, McLeod C, Wang YD, Easton J, Rusch M, Dalton J, Downing JR, Ellison DW, Zhang J, Baker SJ, Wu G
Acta Neuropathol 2019 Jan;137(1):123-137. Epub 2018 Sep 28 doi: 10.1007/s00401-018-1912-1. PMID: 30267146 Free PMC Article

An integrative framework for the identification of double minute chromosomes using next generation sequencing data.

Hayes M, Li J
BMC Genet 2015;16 Suppl 2(Suppl 2):S1. Epub 2015 Apr 23 doi: 10.1186/1471-2156-16-S2-S1. PMID: 25953282 Free PMC Article

Oncogene amplification in solid tumors.

Schwab M
Semin Cancer Biol 1999 Aug;9(4):319-25. doi: 10.1006/scbi.1999.0126. PMID: 10448118

Cytogenetic studies in prostate cancer: are we making progress?

Brothman AR
Cancer Genet Cytogenet 1997 May;95(1):116-21. doi: 10.1016/s0165-4608(96)00302-0. PMID: 9140461

See all (68)

Therapy

Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges.

The adaptive potential of circular DNA accumulation in ageing cells.

Hull RM, Houseley J
Curr Genet 2020 Oct;66(5):889-894. Epub 2020 Apr 15 doi: 10.1007/s00294-020-01069-9. PMID: 32296868 Free PMC Article

Double-strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation.

Oobatake Y, Shimizu N
Genes Chromosomes Cancer 2020 Mar;59(3):133-143. Epub 2019 Oct 4 doi: 10.1002/gcc.22810. PMID: 31569279

Formation of non-random extrachromosomal elements during development, differentiation and oncogenesis.

Kuttler F, Mai S
Semin Cancer Biol 2007 Feb;17(1):56-64. Epub 2006 Oct 26 doi: 10.1016/j.semcancer.2006.10.007. PMID: 17116402

Cytogenetic studies in prostate cancer: are we making progress?

Brothman AR
Cancer Genet Cytogenet 1997 May;95(1):116-21. doi: 10.1016/s0165-4608(96)00302-0. PMID: 9140461

See all (48)

Prognosis

Breaking the vicious circle: Extrachromosomal circular DNA as an emerging player in tumour evolution.

Robert M, Crasta K
Semin Cell Dev Biol 2022 Mar;123:140-150. Epub 2021 Nov 29 doi: 10.1016/j.semcdb.2021.11.015. PMID: 34857471

Molecular structure and evolution mechanism of two populations of double minutes in human colorectal cancer cells.

Jia X, Guan R, Cui X, Zhu J, Liu P, Zhang L, Wang D, Zhang Y, Dong K, Wu J, Ji W, Ji G, Bai J, Yu J, Yu Y, Sun W, Zhang F, Fu S
J Cell Mol Med 2020 Dec;24(24):14205-14216. Epub 2020 Oct 30 doi: 10.1111/jcmm.16035. PMID: 33124133 Free PMC Article

An integrative framework for the identification of double minute chromosomes using next generation sequencing data.

Hayes M, Li J
BMC Genet 2015;16 Suppl 2(Suppl 2):S1. Epub 2015 Apr 23 doi: 10.1186/1471-2156-16-S2-S1. PMID: 25953282 Free PMC Article

Extrachromosomal double minutes and chromosomal homogeneously staining regions as probes for chromosome research.

Shimizu N
Cytogenet Genome Res 2009;124(3-4):312-26. Epub 2009 Jun 25 doi: 10.1159/000218135. PMID: 19556783

Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review.

Gebhart E
Clin Transl Oncol 2005 Dec;7(11):477-85. doi: 10.1007/BF02717000. PMID: 16373058

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Clinical prediction guides

PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance.

Carlotto BS, Trevisan P, Provenzi VO, Soares FP, Rosa RFM, Varella-Garcia M, Zen PRG
Neuromolecular Med 2023 Sep;25(3):441-450. Epub 2023 Aug 23 doi: 10.1007/s12017-023-08749-y. PMID: 37610648 Free PMC Article

Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges.

Structure and evolution of double minutes in diagnosis and relapse brain tumors.

Extrachromosomal double minutes and chromosomal homogeneously staining regions as probes for chromosome research.

Shimizu N
Cytogenet Genome Res 2009;124(3-4):312-26. Epub 2009 Jun 25 doi: 10.1159/000218135. PMID: 19556783

Molecular biology of double-minute chromosomes.

Hahn PJ
Bioessays 1993 Jul;15(7):477-84. doi: 10.1002/bies.950150707. PMID: 7691058

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