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High-Frequency Microsatellite Instability

MedGen UID:
268853
•Concept ID:
C1512430
•
Cell or Molecular Dysfunction
Synonyms: Microsatellite Instability High; Microsatellite Instability-High

Definition

The presence of genomic instability associated with defective DNA mismatch repair in greater than 30% of the microsatellite instability (MSI) biomarkers in a tumor sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh-Frequency Microsatellite Instability

Professional guidelines

PubMed

Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers.
Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Detection of mononucleotide repeat sequence alterations in a large background of normal DNA for screening high-frequency microsatellite instability cancers.
Sun X, Liu Y, Lutterbaugh J, Chen WD, Markowitz SD, Guo B
Clin Cancer Res 2006 Jan 15;12(2):454-9. doi: 10.1158/1078-0432.CCR-05-0919. PMID: 16428486
Hereditary nonpolyposis colorectal cancer (Lynch syndrome): criteria for identification and management.
Kouraklis G, Misiakos EP
Dig Dis Sci 2005 Feb;50(2):336-44. doi: 10.1007/s10620-005-1607-z. PMID: 15745097

Recent clinical studies

Etiology

Determination of therapeutic agents efficiencies of microsatellite instability high colon cancer cells in post-metastatic liver biochip modeling.
Bayir Garbioglu D, Demir N, Ozel C, Avci H, Dincer M
FASEB J 2021 Sep;35(9):e21834. doi: 10.1096/fj.202100333R. PMID: 34403553
Microsatellite instability in Japanese female patients with triple-negative breast cancer.
Kurata K, Kubo M, Kai M, Mori H, Kawaji H, Kaneshiro K, Yamada M, Nishimura R, Osako T, Arima N, Okido M, Oda Y, Nakamura M
Breast Cancer 2020 May;27(3):490-498. Epub 2020 Jan 6 doi: 10.1007/s12282-019-01043-5. PMID: 31907878Free PMC Article
Low-frequency microsatellite instability in genomic di-nucleotide sequences correlates with lymphatic invasion and poor prognosis in gastric cancer.
Zhao Y, Zheng ZC, Luo YH, Piao HZ, Zheng GL, Shi JY, Zhang T, Zhang JJ
Cell Biochem Biophys 2015 Jan;71(1):235-41. doi: 10.1007/s12013-014-0189-9. PMID: 25108737
Chemosensitivity and survival in gastric cancer patients with microsatellite instability.
Oki E, Kakeji Y, Zhao Y, Yoshida R, Ando K, Masuda T, Ohgaki K, Morita M, Maehara Y
Ann Surg Oncol 2009 Sep;16(9):2510-5. Epub 2009 Jun 30 doi: 10.1245/s10434-009-0580-8. PMID: 19565284
Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder.
Roa JC, Roa I, Correa P, Vo Q, Araya JC, Villaseca M, Guzmán P, Schneider BG
J Gastroenterol 2005 Jan;40(1):79-86. doi: 10.1007/s00535-004-1497-4. PMID: 15692793

Diagnosis

Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers.
Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age.
Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K
Cancer Med 2017 Jun;6(6):1255-1263. Epub 2017 May 23 doi: 10.1002/cam4.1088. PMID: 28544821Free PMC Article
Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers.
Kim CG, Ahn JB, Jung M, Beom SH, Kim C, Kim JH, Heo SJ, Park HS, Kim JH, Kim NK, Min BS, Kim H, Koom WS, Shin SJ
Br J Cancer 2016 Jun 28;115(1):25-33. Epub 2016 May 26 doi: 10.1038/bjc.2016.161. PMID: 27228287Free PMC Article
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.
Imai K, Yamamoto H
Carcinogenesis 2008 Apr;29(4):673-80. Epub 2007 Oct 17 doi: 10.1093/carcin/bgm228. PMID: 17942460
Automated, multiplex assay for high-frequency microsatellite instability in colorectal cancer.
Nash GM, Gimbel M, Shia J, Culliford AT, Nathanson DR, Ndubuisi M, Yamaguchi Y, Zeng ZS, Barany F, Paty PB
J Clin Oncol 2003 Aug 15;21(16):3105-12. doi: 10.1200/JCO.2003.11.133. PMID: 12915601

Therapy

Determination of therapeutic agents efficiencies of microsatellite instability high colon cancer cells in post-metastatic liver biochip modeling.
Bayir Garbioglu D, Demir N, Ozel C, Avci H, Dincer M
FASEB J 2021 Sep;35(9):e21834. doi: 10.1096/fj.202100333R. PMID: 34403553
Metastatic Pattern of Stage IV Colorectal Cancer with High-Frequency Microsatellite Instability as a Prognostic Factor.
Fujiyoshi K, Yamamoto G, Takenoya T, Takahashi A, Arai Y, Yamada M, Kakuta M, Yamaguchi K, Akagi Y, Nishimura Y, Sakamoto H, Akagi K
Anticancer Res 2017 Jan;37(1):239-247. doi: 10.21873/anticanres.11313. PMID: 28011498
Chemosensitivity and survival in gastric cancer patients with microsatellite instability.
Oki E, Kakeji Y, Zhao Y, Yoshida R, Ando K, Masuda T, Ohgaki K, Morita M, Maehara Y
Ann Surg Oncol 2009 Sep;16(9):2510-5. Epub 2009 Jun 30 doi: 10.1245/s10434-009-0580-8. PMID: 19565284
The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer.
Warusavitarne J, Schnitzler M
Int J Colorectal Dis 2007 Jul;22(7):739-48. Epub 2006 Nov 16 doi: 10.1007/s00384-006-0228-0. PMID: 17109103
Chemotherapeutic implications in microsatellite unstable colorectal cancer.
Jo WS, Carethers JM
Cancer Biomark 2006;2(1-2):51-60. doi: 10.3233/cbm-2006-21-206. PMID: 17192059Free PMC Article

Prognosis

Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.
Ishino T, Kawashima S, Tanji E, Ueno T, Ueda Y, Ogasawara S, Sato K, Mano H, Ishihara S, Kato N, Kawazu M, Togashi Y
Br J Cancer 2023 Apr;128(6):1166-1175. Epub 2023 Feb 2 doi: 10.1038/s41416-023-02165-6. PMID: 36732592Free PMC Article
Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers.
Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age.
Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K
Cancer Med 2017 Jun;6(6):1255-1263. Epub 2017 May 23 doi: 10.1002/cam4.1088. PMID: 28544821Free PMC Article
Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers.
Kim CG, Ahn JB, Jung M, Beom SH, Kim C, Kim JH, Heo SJ, Park HS, Kim JH, Kim NK, Min BS, Kim H, Koom WS, Shin SJ
Br J Cancer 2016 Jun 28;115(1):25-33. Epub 2016 May 26 doi: 10.1038/bjc.2016.161. PMID: 27228287Free PMC Article
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.
Imai K, Yamamoto H
Carcinogenesis 2008 Apr;29(4):673-80. Epub 2007 Oct 17 doi: 10.1093/carcin/bgm228. PMID: 17942460

Clinical prediction guides

Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.
Ishino T, Kawashima S, Tanji E, Ueno T, Ueda Y, Ogasawara S, Sato K, Mano H, Ishihara S, Kato N, Kawazu M, Togashi Y
Br J Cancer 2023 Apr;128(6):1166-1175. Epub 2023 Feb 2 doi: 10.1038/s41416-023-02165-6. PMID: 36732592Free PMC Article
Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers.
Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age.
Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K
Cancer Med 2017 Jun;6(6):1255-1263. Epub 2017 May 23 doi: 10.1002/cam4.1088. PMID: 28544821Free PMC Article
Clinical implications of microsatellite instability in T1 colorectal cancer.
Kang J, Lee HW, Kim IK, Kim NK, Sohn SK, Lee KY
Yonsei Med J 2015 Jan;56(1):175-81. doi: 10.3349/ymj.2015.56.1.175. PMID: 25510762Free PMC Article
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.
Imai K, Yamamoto H
Carcinogenesis 2008 Apr;29(4):673-80. Epub 2007 Oct 17 doi: 10.1093/carcin/bgm228. PMID: 17942460

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