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High-Frequency Microsatellite Instability

MedGen UID:
268853
Concept ID:
C1512430
Cell or Molecular Dysfunction
Synonyms: Microsatellite Instability High; Microsatellite Instability-High

Definition

The presence of genomic instability associated with defective DNA mismatch repair in greater than 30% of the microsatellite instability (MSI) biomarkers in a tumor sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh-Frequency Microsatellite Instability

Professional guidelines

PubMed

Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Sun X, Liu Y, Lutterbaugh J, Chen WD, Markowitz SD, Guo B
Clin Cancer Res 2006 Jan 15;12(2):454-9. doi: 10.1158/1078-0432.CCR-05-0919. PMID: 16428486
Kouraklis G, Misiakos EP
Dig Dis Sci 2005 Feb;50(2):336-44. doi: 10.1007/s10620-005-1607-z. PMID: 15745097

Recent clinical studies

Etiology

Bayir Garbioglu D, Demir N, Ozel C, Avci H, Dincer M
FASEB J 2021 Sep;35(9):e21834. doi: 10.1096/fj.202100333R. PMID: 34403553
Kurata K, Kubo M, Kai M, Mori H, Kawaji H, Kaneshiro K, Yamada M, Nishimura R, Osako T, Arima N, Okido M, Oda Y, Nakamura M
Breast Cancer 2020 May;27(3):490-498. Epub 2020 Jan 6 doi: 10.1007/s12282-019-01043-5. PMID: 31907878Free PMC Article
Zhao Y, Zheng ZC, Luo YH, Piao HZ, Zheng GL, Shi JY, Zhang T, Zhang JJ
Cell Biochem Biophys 2015 Jan;71(1):235-41. doi: 10.1007/s12013-014-0189-9. PMID: 25108737
Markovic S, Antic J, Dragicevic N, Hamelin R, Krivokapic Z
J Mol Histol 2012 Apr;43(2):137-43. Epub 2012 Jan 1 doi: 10.1007/s10735-011-9387-6. PMID: 22210186
Roa JC, Roa I, Correa P, Vo Q, Araya JC, Villaseca M, Guzmán P, Schneider BG
J Gastroenterol 2005 Jan;40(1):79-86. doi: 10.1007/s00535-004-1497-4. PMID: 15692793

Diagnosis

Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K
Cancer Med 2017 Jun;6(6):1255-1263. Epub 2017 May 23 doi: 10.1002/cam4.1088. PMID: 28544821Free PMC Article
Kim CG, Ahn JB, Jung M, Beom SH, Kim C, Kim JH, Heo SJ, Park HS, Kim JH, Kim NK, Min BS, Kim H, Koom WS, Shin SJ
Br J Cancer 2016 Jun 28;115(1):25-33. Epub 2016 May 26 doi: 10.1038/bjc.2016.161. PMID: 27228287Free PMC Article
Imai K, Yamamoto H
Carcinogenesis 2008 Apr;29(4):673-80. Epub 2007 Oct 17 doi: 10.1093/carcin/bgm228. PMID: 17942460
Nash GM, Gimbel M, Shia J, Culliford AT, Nathanson DR, Ndubuisi M, Yamaguchi Y, Zeng ZS, Barany F, Paty PB
J Clin Oncol 2003 Aug 15;21(16):3105-12. doi: 10.1200/JCO.2003.11.133. PMID: 12915601

Therapy

Bayir Garbioglu D, Demir N, Ozel C, Avci H, Dincer M
FASEB J 2021 Sep;35(9):e21834. doi: 10.1096/fj.202100333R. PMID: 34403553
Fujiyoshi K, Yamamoto G, Takenoya T, Takahashi A, Arai Y, Yamada M, Kakuta M, Yamaguchi K, Akagi Y, Nishimura Y, Sakamoto H, Akagi K
Anticancer Res 2017 Jan;37(1):239-247. doi: 10.21873/anticanres.11313. PMID: 28011498
Oki E, Kakeji Y, Zhao Y, Yoshida R, Ando K, Masuda T, Ohgaki K, Morita M, Maehara Y
Ann Surg Oncol 2009 Sep;16(9):2510-5. Epub 2009 Jun 30 doi: 10.1245/s10434-009-0580-8. PMID: 19565284
Warusavitarne J, Schnitzler M
Int J Colorectal Dis 2007 Jul;22(7):739-48. Epub 2006 Nov 16 doi: 10.1007/s00384-006-0228-0. PMID: 17109103
Jo WS, Carethers JM
Cancer Biomark 2006;2(1-2):51-60. doi: 10.3233/cbm-2006-21-206. PMID: 17192059Free PMC Article

Prognosis

Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K
Cancer Med 2017 Jun;6(6):1255-1263. Epub 2017 May 23 doi: 10.1002/cam4.1088. PMID: 28544821Free PMC Article
Kim CG, Ahn JB, Jung M, Beom SH, Kim C, Kim JH, Heo SJ, Park HS, Kim JH, Kim NK, Min BS, Kim H, Koom WS, Shin SJ
Br J Cancer 2016 Jun 28;115(1):25-33. Epub 2016 May 26 doi: 10.1038/bjc.2016.161. PMID: 27228287Free PMC Article
Imai K, Yamamoto H
Carcinogenesis 2008 Apr;29(4):673-80. Epub 2007 Oct 17 doi: 10.1093/carcin/bgm228. PMID: 17942460
Jo WS, Carethers JM
Cancer Biomark 2006;2(1-2):51-60. doi: 10.3233/cbm-2006-21-206. PMID: 17192059Free PMC Article

Clinical prediction guides

Chang L, Chang M, Chang HM, Chang F
J Gastrointest Cancer 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. PMID: 28699072Free PMC Article
Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K
Cancer Med 2017 Jun;6(6):1255-1263. Epub 2017 May 23 doi: 10.1002/cam4.1088. PMID: 28544821Free PMC Article
Kang J, Lee HW, Kim IK, Kim NK, Sohn SK, Lee KY
Yonsei Med J 2015 Jan;56(1):175-81. doi: 10.3349/ymj.2015.56.1.175. PMID: 25510762Free PMC Article
Imai K, Yamamoto H
Carcinogenesis 2008 Apr;29(4):673-80. Epub 2007 Oct 17 doi: 10.1093/carcin/bgm228. PMID: 17942460
Jo WS, Carethers JM
Cancer Biomark 2006;2(1-2):51-60. doi: 10.3233/cbm-2006-21-206. PMID: 17192059Free PMC Article

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