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Homogeneously Staining Region

MedGen UID:
268869
•Concept ID:
C1512486
•
Cell or Molecular Dysfunction

Definition

A region on a chromosome which, when stained, is uniform in appearance. (Normally, a stained chromosome shows a banding pattern.) Homogeneously staining regions contain multiple copies of a single gene. (Online Medical Dictionary) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHomogeneously Staining Region

Professional guidelines

PubMed

Designing and characterization of curcumin-loaded nanotechnological dressings: A promising platform for skin burn treatment.
de Moraes Soares Araújo G, Lima Rodrigues J, Campello Yurgel V, Silva C, Manuel Cavaco Paulo A, Isabel Saì Loureiro A, Lima Dora C
Int J Pharm 2023 Mar 25;635:122712. Epub 2023 Feb 15 doi: 10.1016/j.ijpharm.2023.122712. PMID: 36803927
A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop.
Roberts DJ, Edlow AG, Romero RJ, Coyne CB, Ting DT, Hornick JL, Zaki SR, Das Adhikari U, Serghides L, Gaw SL, Metz TD; National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop
Am J Obstet Gynecol 2021 Dec;225(6):593.e1-593.e9. Epub 2021 Aug 5 doi: 10.1016/j.ajog.2021.07.029. PMID: 34364845Free PMC Article
Evaluation of critical aspects in clinical and forensic management of sexual violence: A multicentre Ge.F.I. project.
Gino S, Bo M, Ricciardelli R, Alù M, Boschi I, Carnevali E, Fabbri M, Fattorini P, Piccinini A, Previderè C, Verzeletti A, Tozzo P, Caenazzo L
Forensic Sci Int 2020 Sep;314:110387. Epub 2020 Jun 23 doi: 10.1016/j.forsciint.2020.110387. PMID: 32650206

Recent clinical studies

Etiology

Homogeneously staining region (hsr) on chromosome 11 is highly specific for KMT2A amplification in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
Sakhdari A, Tang Z, Ok CY, Bueso-Ramos CE, Medeiros LJ, Huh YO
Cancer Genet 2019 Oct;238:18-22. Epub 2019 Jul 5 doi: 10.1016/j.cancergen.2019.07.001. PMID: 31425921
Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemia.
Villa O, Salido M, Pérez-Vila ME, Ferrer A, Arenillas L, Pedro C, Espinet B, Corzo C, Serrano S, Woessner S, Florensa L, Solé F
Cancer Genet Cytogenet 2008 Aug;185(1):32-6. doi: 10.1016/j.cancergencyto.2008.04.014. PMID: 18656691
Gene expression microarray analysis and genome databases facilitate the characterization of a chromosome 22 derived homogeneously staining region.
Arcand SL, Mes-Masson AM, Provencher D, Hudson TJ, Tonin PN
Mol Carcinog 2004 Sep;41(1):17-38. doi: 10.1002/mc.20038. PMID: 15352123
Cytogenetics of chronic myelomonocytic leukemia.
Cancer Genet Cytogenet 1986 Mar 1;21(1):11-30. doi: 10.1016/0165-4608(86)90197-4. PMID: 3455874
Cytogenetic studies of human breast cancer lines: MCF-7 and derived variant sublines.
Whang-Peng J, Lee EC, Kao-Shan CS, Seibert K, Lippman M
J Natl Cancer Inst 1983 Oct;71(4):687-95. PMID: 6578363

Diagnosis

Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate‑resistant human colorectal cancer cells.
Wang X, Qu Y, Xing R, Zhou J, Liu Y, Zhang H, Zhu J, Ma J, Cui X, Song T, Xing S, Ji G, Liu P, Sun W, Fu S, Meng X
Int J Oncol 2023 Dec;63(6) Epub 2023 Oct 27 doi: 10.3892/ijo.2023.5582. PMID: 37888748Free PMC Article
Advancements in Focal Amplification Detection in Tumor/Liquid Biopsies and Emerging Clinical Applications.
Arshadi A, Tolomeo D, Venuto S, Storlazzi CT
Genes (Basel) 2023 Jun 20;14(6) doi: 10.3390/genes14061304. PMID: 37372484Free PMC Article
Polycythemia vera transforming to acute myeloid leukemia and complex abnormalities including 9p homogeneously staining region with amplification of MLLT3, JMJD2C, JAK2, and SMARCA2.
Hélias C, Struski S, Gervais C, Leymarie V, Mauvieux L, Herbrecht R, Lessard M
Cancer Genet Cytogenet 2008 Jan 1;180(1):51-5. doi: 10.1016/j.cancergencyto.2007.09.010. PMID: 18068534
ERBB2 amplifications in esophageal adenocarcinoma.
Dahlberg PS, Jacobson BA, Dahal G, Fink JM, Kratzke RA, Maddaus MA, Ferrin LJ
Ann Thorac Surg 2004 Nov;78(5):1790-800. doi: 10.1016/j.athoracsur.2004.05.037. PMID: 15511476
Homogeneously staining region in anthracycline-resistant HL-60/AR cells not associated with MDR1 amplification.
Gervasoni JE Jr, Taub RN, Yu MT, Warburton D, Sabbath M, Gilleran S, Coppock DL, D'Alessandri J, Krishna S, Rosado M
Cancer Res 1992 Oct 1;52(19):5244-9. PMID: 1394128

Therapy

Del(5q) and MLL amplification in homogeneously staining region in acute myeloblastic leukemia: a recurrent cytogenetic association.
Herry A, Douet-Guilbert N, Guéganic N, Morel F, Le Bris MJ, Berthou C, De Braekeleer M
Ann Hematol 2006 Apr;85(4):244-9. Epub 2006 Jan 20 doi: 10.1007/s00277-005-0059-z. PMID: 16425025
Twenty-four-color spectral karyotyping reveals chromosome aberrations in cytogenetically normal acute myeloid leukemia.
Zhang FF, Murata-Collins JL, Gaytan P, Forman SJ, Kopecky KJ, Willman CL, Appelbaum FR, Slovak ML
Genes Chromosomes Cancer 2000 Jul;28(3):318-28. doi: 10.1002/1098-2264(200007)28:3<318::aid-gcc10>3.0.co;2-m. PMID: 10862038
Jumping translocation of homogeneously staining region and tetraploidy with double minutes in acute myelomonocytic leukemia.
Yoshida T, Kimura N, Akiyoshi T, Ohshima K, Nagano M, Morioka E, Hisano S, Ohyashiki K, Kamada N, Tamura K
Cancer Genet Cytogenet 1999 Feb;109(1):40-4. doi: 10.1016/s0165-4608(98)00144-7. PMID: 9973958
Sequential emergence of MRP- and MDR1-gene over-expression as well as MDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines.
Zhou DC, Ramond S, Viguie F, Faussat AM, Zittoun R, Marie JP
Int J Cancer 1996 Jan 26;65(3):365-71. doi: 10.1002/(SICI)1097-0215(19960126)65:3<365::AID-IJC15>3.0.CO;2-9. PMID: 8575859
Patterns of BrdU incorporation in homogeneously staining regions and double minutes.
Krawczun MS, Camargo M, Cervenka J
Cancer Genet Cytogenet 1986 Apr 1;21(3):257-65. doi: 10.1016/0165-4608(86)90006-3. PMID: 2418948

Prognosis

Advancements in Focal Amplification Detection in Tumor/Liquid Biopsies and Emerging Clinical Applications.
Arshadi A, Tolomeo D, Venuto S, Storlazzi CT
Genes (Basel) 2023 Jun 20;14(6) doi: 10.3390/genes14061304. PMID: 37372484Free PMC Article
Homogeneously staining region (hsr) on chromosome 11 is highly specific for KMT2A amplification in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
Sakhdari A, Tang Z, Ok CY, Bueso-Ramos CE, Medeiros LJ, Huh YO
Cancer Genet 2019 Oct;238:18-22. Epub 2019 Jul 5 doi: 10.1016/j.cancergen.2019.07.001. PMID: 31425921
Extrachromosomal double minutes and chromosomal homogeneously staining regions as probes for chromosome research.
Shimizu N
Cytogenet Genome Res 2009;124(3-4):312-26. Epub 2009 Jun 25 doi: 10.1159/000218135. PMID: 19556783
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Martin CL, Reshmi SC, Ried T, Gottberg W, Wilson JW, Reddy JK, Khanna P, Johnson JT, Myers EN, Gollin SM
Oral Oncol 2008 Apr;44(4):369-82. Epub 2007 Aug 2 doi: 10.1016/j.oraloncology.2007.05.003. PMID: 17681875Free PMC Article
Homogeneously staining regions in 223 breast carcinomas: cytogenetic and clinicopathological correlations.
Bernardino J, Gerbault-Seureau M, Zafrani B, Dericke Y, Boudou E, Magdelenat H, Dutrillaux B
Br J Cancer 1998 Nov;78(9):1214-8. doi: 10.1038/bjc.1998.657. PMID: 9820183Free PMC Article

Clinical prediction guides

Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate‑resistant human colorectal cancer cells.
Wang X, Qu Y, Xing R, Zhou J, Liu Y, Zhang H, Zhu J, Ma J, Cui X, Song T, Xing S, Ji G, Liu P, Sun W, Fu S, Meng X
Int J Oncol 2023 Dec;63(6) Epub 2023 Oct 27 doi: 10.3892/ijo.2023.5582. PMID: 37888748Free PMC Article
SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing.
Taniguchi R, Utani K, Thakur B, Ishine K, Aladjem MI, Shimizu N
J Biol Chem 2021 Jan-Jun;296:100356. Epub 2021 Feb 2 doi: 10.1016/j.jbc.2021.100356. PMID: 33539925Free PMC Article
Extrachromosomal double minutes and chromosomal homogeneously staining regions as probes for chromosome research.
Shimizu N
Cytogenet Genome Res 2009;124(3-4):312-26. Epub 2009 Jun 25 doi: 10.1159/000218135. PMID: 19556783
Simultaneous existence of double minute chromosomes and a homogeneously staining region in a retinoblastoma cell line (Y79) and amplification of N-myc at HSR.
Inazawa J, Abe T, Inoue K, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Takino T
Cancer Genet Cytogenet 1989 Jan;37(1):133-7. doi: 10.1016/0165-4608(89)90082-4. PMID: 2917328
Patterns of BrdU incorporation in homogeneously staining regions and double minutes.
Krawczun MS, Camargo M, Cervenka J
Cancer Genet Cytogenet 1986 Apr 1;21(3):257-65. doi: 10.1016/0165-4608(86)90006-3. PMID: 2418948

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