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Infiltrating bladder urothelial carcinoma sarcomatoid variant

MedGen UID:
268929
•Concept ID:
C1512743
•
Neoplastic Process
Synonyms: Bladder Carcinosarcoma; Bladder Sarcomatoid Urothelial Carcinoma; infiltrating bladder urothelial carcinoma sarcomatoid variant; Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant; Invasive Bladder Sarcomatoid Urothelial Carcinoma; Invasive Bladder Urothelial Carcinoma, Sarcomatoid Variant
 
Monarch Initiative: MONDO:0004278

Definition

An invasive urothelial carcinoma of the bladder that exhibits spindle cell sarcomatoid features. [from NCI]

Recent clinical studies

Etiology

Receptor Tyrosine Kinase Pathway and Infiltrating Urothelial Carcinoma.
Buyucek S, Coskun SK, Onal B, Gamsizkan M, Cangur S, Esbah O
J Environ Pathol Toxicol Oncol 2023;42(1):65-77. doi: 10.1615/JEnvironPatholToxicolOncol.2022044380. PMID: 36734953
Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study.
Elwy AE, Elsaba TM, Abd Elzaher AR, Nassar MI
Asian Pac J Cancer Prev 2019 Dec 1;20(12):3735-3746. doi: 10.31557/APJCP.2019.20.12.3735. PMID: 31870116Free PMC Article

Diagnosis

Giant cell carcinoma of the urinary bladder : Clinicopathologic analysis and oncological outcomes.
Portugal-Gaspar F, Lopez-Beltran A, Paner GP, Blanca A, Gómez EG, Montironi R, Cimadamore A, Bilé A, Volavšek M, Cheng L
Virchows Arch 2024 Sep;485(3):535-546. Epub 2024 Jul 18 doi: 10.1007/s00428-024-03858-w. PMID: 39023556Free PMC Article
Urothelial carcinoma of the bladder, lipid cell variant: clinicopathologic findings and LOH analysis.
Lopez-Beltran A, Amin MB, Oliveira PS, Montironi R, Algaba F, McKenney JK, de Torres I, Mazerolles C, Wang M, Cheng L
Am J Surg Pathol 2010 Mar;34(3):371-6. doi: 10.1097/PAS.0b013e3181cd385b. PMID: 20139762
High-grade urothelial carcinoma of the renal pelvis: clinicopathologic study of 108 cases with emphasis on unusual morphologic variants.
Perez-Montiel D, Wakely PE, Hes O, Michal M, Suster S
Mod Pathol 2006 Apr;19(4):494-503. doi: 10.1038/modpathol.3800559. PMID: 16474378

Prognosis

Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study.
Elwy AE, Elsaba TM, Abd Elzaher AR, Nassar MI
Asian Pac J Cancer Prev 2019 Dec 1;20(12):3735-3746. doi: 10.31557/APJCP.2019.20.12.3735. PMID: 31870116Free PMC Article
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer.
Guo CC, Majewski T, Zhang L, Yao H, Bondaruk J, Wang Y, Zhang S, Wang Z, Lee JG, Lee S, Cogdell D, Zhang M, Wei P, Grossman HB, Kamat A, Duplisea JJ, Ferguson JE 3rd, Huang H, Dadhania V, Gao J, Dinney C, Weinstein JN, Baggerly K, McConkey D, Czerniak B
Cell Rep 2019 May 7;27(6):1781-1793.e4. doi: 10.1016/j.celrep.2019.04.048. PMID: 31067463Free PMC Article
Cutaneous invasion from sarcomatoid urothelial carcinoma: clinical and dermatopathologic features.
Bernardes Filho F, de Melo AS, Pires AR, Lupi O, das Neves DG, da Cruz MF, Kac BK
An Bras Dermatol 2016 Jan-Feb;91(1):73-9. doi: 10.1590/abd1806-4841.20164081. PMID: 26982782Free PMC Article
Urothelial carcinoma of the bladder, lipid cell variant: clinicopathologic findings and LOH analysis.
Lopez-Beltran A, Amin MB, Oliveira PS, Montironi R, Algaba F, McKenney JK, de Torres I, Mazerolles C, Wang M, Cheng L
Am J Surg Pathol 2010 Mar;34(3):371-6. doi: 10.1097/PAS.0b013e3181cd385b. PMID: 20139762

Clinical prediction guides

Giant cell carcinoma of the urinary bladder : Clinicopathologic analysis and oncological outcomes.
Portugal-Gaspar F, Lopez-Beltran A, Paner GP, Blanca A, Gómez EG, Montironi R, Cimadamore A, Bilé A, Volavšek M, Cheng L
Virchows Arch 2024 Sep;485(3):535-546. Epub 2024 Jul 18 doi: 10.1007/s00428-024-03858-w. PMID: 39023556Free PMC Article
Receptor Tyrosine Kinase Pathway and Infiltrating Urothelial Carcinoma.
Buyucek S, Coskun SK, Onal B, Gamsizkan M, Cangur S, Esbah O
J Environ Pathol Toxicol Oncol 2023;42(1):65-77. doi: 10.1615/JEnvironPatholToxicolOncol.2022044380. PMID: 36734953
Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study.
Elwy AE, Elsaba TM, Abd Elzaher AR, Nassar MI
Asian Pac J Cancer Prev 2019 Dec 1;20(12):3735-3746. doi: 10.31557/APJCP.2019.20.12.3735. PMID: 31870116Free PMC Article
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer.
Guo CC, Majewski T, Zhang L, Yao H, Bondaruk J, Wang Y, Zhang S, Wang Z, Lee JG, Lee S, Cogdell D, Zhang M, Wei P, Grossman HB, Kamat A, Duplisea JJ, Ferguson JE 3rd, Huang H, Dadhania V, Gao J, Dinney C, Weinstein JN, Baggerly K, McConkey D, Czerniak B
Cell Rep 2019 May 7;27(6):1781-1793.e4. doi: 10.1016/j.celrep.2019.04.048. PMID: 31067463Free PMC Article
Urothelial carcinoma of the bladder, lipid cell variant: clinicopathologic findings and LOH analysis.
Lopez-Beltran A, Amin MB, Oliveira PS, Montironi R, Algaba F, McKenney JK, de Torres I, Mazerolles C, Wang M, Cheng L
Am J Surg Pathol 2010 Mar;34(3):371-6. doi: 10.1097/PAS.0b013e3181cd385b. PMID: 20139762

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