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Maturing Ganglioneuroma

MedGen UID:
269163
•Concept ID:
C1513034
•
Neoplastic Process

Definition

A ganglioneuroma characterized by the presence of differentiating neuroblasts, maturing and mature ganglion cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMaturing Ganglioneuroma

Professional guidelines

PubMed

Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee.
Suganuma R, Wang LL, Sano H, Naranjo A, London WB, Seeger RC, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Amann G, Beiske K, Cullinane CJ, d'Amore ES, Gambini C, Jarzembowski JA, Joshi VV, Navarro S, Peuchmaur M, Shimada H
Pediatr Blood Cancer 2013 Mar;60(3):363-70. Epub 2012 Jun 28 doi: 10.1002/pbc.24238. PMID: 22744966Free PMC Article

Recent clinical studies

Etiology

Genetic and Histopathological Heterogeneity of Neuroblastoma and Precision Therapeutic Approaches for Extremely Unfavorable Histology Subgroups.
Shimada H, Ikegaki N
Biomolecules 2022 Jan 5;12(1) doi: 10.3390/biom12010079. PMID: 35053227Free PMC Article
Role and toxicity of radiation therapy in neuroblastoma patients: A literature review.
Zhao Q, Liu Y, Zhang Y, Meng L, Wei J, Wang B, Wang H, Xin Y, Dong L, Jiang X
Crit Rev Oncol Hematol 2020 May;149:102924. Epub 2020 Mar 3 doi: 10.1016/j.critrevonc.2020.102924. PMID: 32172225
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.
Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H
Pediatr Blood Cancer 2009 Oct;53(4):563-9. doi: 10.1002/pbc.22106. PMID: 19530234Free PMC Article
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723

Diagnosis

Maturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children.
Sarnat HB, Chan ES, Ng D, Yu W
J Neuropathol Exp Neurol 2023 Sep 20;82(10):853-864. doi: 10.1093/jnen/nlad068. PMID: 37682248
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Nonepithelial Neoplasms of the Pancreas: Radiologic-Pathologic Correlation, Part 1--Benign Tumors: From the Radiologic Pathology Archives.
Manning MA, Srivastava A, Paal EE, Gould CF, Mortele KJ
Radiographics 2016 Jan-Feb;36(1):123-41. doi: 10.1148/rg.2016150212. PMID: 26761535
Metastatic ganglioneuroma: a misnomer.
DasGupta S, Das RN, Mishra PK, Chatterjee U, Datta C
Indian J Pathol Microbiol 2014 Jul-Sep;57(3):445-6. doi: 10.4103/0377-4929.138753. PMID: 25118741
Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.
Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H
Pediatr Blood Cancer 2009 Oct;53(4):563-9. doi: 10.1002/pbc.22106. PMID: 19530234Free PMC Article

Therapy

Mixed Pituitary Gangliocytoma and Prolactinoma Resistant to the Cabergoline Treatment.
Yano S, Hide T, Uekawa K, Honda Y, Mikami Y, Kuratsu JI
World Neurosurg 2016 Nov;95:620.e17-620.e22. Epub 2016 Aug 13 doi: 10.1016/j.wneu.2016.08.011. PMID: 27535625
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Adrenal ganglioneuromas: incidentalomas with misleading clinical and imaging features.
Linos D, Tsirlis T, Kapralou A, Kiriakopoulos A, Tsakayannis D, Papaioannou D
Surgery 2011 Jan;149(1):99-105. Epub 2010 May 10 doi: 10.1016/j.surg.2010.03.016. PMID: 20452635
Clinical and pharmacokinetic studies of all-trans-retinoic acid in pediatric patients with cancer.
Adamson PC
Leukemia 1994 Nov;8(11):1813-6. PMID: 7967727
Recent advances in neuroblastoma.
Finklestein JZ, Gilchrist GS
Calif Med 1972 Mar;116(3):27-36. PMID: 4622580Free PMC Article

Prognosis

Ganglion cell maturation in peripheral neuroblastic tumours of children.
Sarnat HB, Yu W
Clin Neuropathol 2022 May-Jun;41(3):101-113. doi: 10.5414/NP301450. PMID: 35142286
Genetic and Histopathological Heterogeneity of Neuroblastoma and Precision Therapeutic Approaches for Extremely Unfavorable Histology Subgroups.
Shimada H, Ikegaki N
Biomolecules 2022 Jan 5;12(1) doi: 10.3390/biom12010079. PMID: 35053227Free PMC Article
Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.
Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H
Pediatr Blood Cancer 2009 Oct;53(4):563-9. doi: 10.1002/pbc.22106. PMID: 19530234Free PMC Article
The contribution of associated congenital anomalies in understanding Hirschsprung's disease.
Moore SW
Pediatr Surg Int 2006 Apr;22(4):305-15. Epub 2006 Mar 4 doi: 10.1007/s00383-006-1655-2. PMID: 16518596
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723

Clinical prediction guides

N6-methyladenosine-mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling.
Liu Y, Zhang J, Cao F, Dong X, Li J, Cao Y, Li Z, Guo Y, Yan J, Liu Y, Zhao Q
JCI Insight 2023 Nov 22;8(22) doi: 10.1172/jci.insight.165703. PMID: 37991019Free PMC Article
Genetic and Histopathological Heterogeneity of Neuroblastoma and Precision Therapeutic Approaches for Extremely Unfavorable Histology Subgroups.
Shimada H, Ikegaki N
Biomolecules 2022 Jan 5;12(1) doi: 10.3390/biom12010079. PMID: 35053227Free PMC Article
Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.
Berthold F, Rosswog C, Christiansen H, Frühwald M, Hemstedt N, Klingebiel T, Fröhlich B, Schilling FH, Schmid I, Simon T, Hero B, Fischer M, Ernst A
Pediatr Blood Cancer 2021 Aug;68(8):e29038. Epub 2021 Apr 7 doi: 10.1002/pbc.29038. PMID: 33826231
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Infrasellar pituitary gangliocytoma causing Cushing's syndrome.
Domingue ME, Marbaix E, Do Rego JL, Col V, Raftopoulos C, Duprez T, Vaudry H, Maiter D
Pituitary 2015 Oct;18(5):738-44. doi: 10.1007/s11102-014-0595-4. PMID: 25183169

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