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Monosomy 6

MedGen UID:
269277
Concept ID:
C1513482
Cell or Molecular Dysfunction

Definition

A chromosomal abnormality consisting of the absence of one complete copy of chromosome 6 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonosomy 6

Professional guidelines

PubMed

Hasle H
Leuk Lymphoma 1994 Mar;13(1-2):11-26. doi: 10.3109/10428199409051647. PMID: 8025513

Recent clinical studies

Etiology

Vriend J, Liu XQ
Int J Mol Sci 2024 Jul 9;25(14) doi: 10.3390/ijms25147506. PMID: 39062749Free PMC Article
Goschzik T, Mynarek M, Doerner E, Schenk A, Spier I, Warmuth-Metz M, Bison B, Obrecht D, Struve N, Kortmann RD, Schmid M, Aretz S, Rutkowski S, Pietsch T
Acta Neuropathol 2022 Dec;144(6):1143-1156. Epub 2022 Oct 1 doi: 10.1007/s00401-022-02505-5. PMID: 36181537Free PMC Article
Cambruzzi E
Childs Nerv Syst 2018 May;34(5):809-815. Epub 2018 Mar 26 doi: 10.1007/s00381-018-3765-2. PMID: 29582169
Ellison DW, Dalton J, Kocak M, Nicholson SL, Fraga C, Neale G, Kenney AM, Brat DJ, Perry A, Yong WH, Taylor RE, Bailey S, Clifford SC, Gilbertson RJ
Acta Neuropathol 2011 Mar;121(3):381-96. Epub 2011 Jan 26 doi: 10.1007/s00401-011-0800-8. PMID: 21267586Free PMC Article
Gulino A, Arcella A, Giangaspero F
Curr Opin Oncol 2008 Nov;20(6):668-75. doi: 10.1097/CCO.0b013e32831369f4. PMID: 18841049

Diagnosis

Goschzik T, Zur Muehlen A, Doerner E, Waha A, Friedrich C, Hau P, Pietsch T
J Neuropathol Exp Neurol 2021 Apr 16;80(5):419-430. doi: 10.1093/jnen/nlab020. PMID: 33870422
Korshunov A, Sahm F, Zheludkova O, Golanov A, Stichel D, Schrimpf D, Ryzhova M, Potapov A, Habel A, Meyer J, Lichter P, Jones DTW, von Deimling A, Pfister SM, Kool M
Neuro Oncol 2019 Feb 14;21(2):214-221. doi: 10.1093/neuonc/noy155. PMID: 30252101Free PMC Article
Shields CL, Say EAT, Hasanreisoglu M, Saktanasate J, Lawson BM, Landy JE, Badami AU, Sivalingam MD, Hauschild AJ, House RJ, Daitch ZE, Mashayekhi A, Shields JA, Ganguly A
Ophthalmology 2017 Oct;124(10):1523-1531. Epub 2017 May 7 doi: 10.1016/j.ophtha.2017.04.003. PMID: 28495150
Ellison DW, Dalton J, Kocak M, Nicholson SL, Fraga C, Neale G, Kenney AM, Brat DJ, Perry A, Yong WH, Taylor RE, Bailey S, Clifford SC, Gilbertson RJ
Acta Neuropathol 2011 Mar;121(3):381-96. Epub 2011 Jan 26 doi: 10.1007/s00401-011-0800-8. PMID: 21267586Free PMC Article
Urban M, Bommer C, Tennstedt C, Lehmann K, Thiel G, Wegner RD, Bollmann R, Becker R, Schulzke I, Körner H
Am J Med Genet 2002 Mar 1;108(2):97-104. doi: 10.1002/ajmg.10215. PMID: 11857558

Therapy

Goschzik T, Mynarek M, Doerner E, Schenk A, Spier I, Warmuth-Metz M, Bison B, Obrecht D, Struve N, Kortmann RD, Schmid M, Aretz S, Rutkowski S, Pietsch T
Acta Neuropathol 2022 Dec;144(6):1143-1156. Epub 2022 Oct 1 doi: 10.1007/s00401-022-02505-5. PMID: 36181537Free PMC Article
Deogharkar A, Singh SV, Bharambe HS, Paul R, Moiyadi A, Goel A, Shetty P, Sridhar E, Gupta T, Jalali R, Goel N, Gadewal N, Muthukumar S, Shirsat NV
Hum Mol Genet 2021 Aug 28;30(18):1721-1733. doi: 10.1093/hmg/ddab134. PMID: 33949667
Ellison DW, Dalton J, Kocak M, Nicholson SL, Fraga C, Neale G, Kenney AM, Brat DJ, Perry A, Yong WH, Taylor RE, Bailey S, Clifford SC, Gilbertson RJ
Acta Neuropathol 2011 Mar;121(3):381-96. Epub 2011 Jan 26 doi: 10.1007/s00401-011-0800-8. PMID: 21267586Free PMC Article
Ellison DW, Kocak M, Dalton J, Megahed H, Lusher ME, Ryan SL, Zhao W, Nicholson SL, Taylor RE, Bailey S, Clifford SC
J Clin Oncol 2011 Apr 10;29(11):1400-7. Epub 2010 Oct 4 doi: 10.1200/JCO.2010.30.2810. PMID: 20921458Free PMC Article
Shibuya A, Ishii S, Obinata K
Hematology 2002 Oct;7(5):301-4. doi: 10.1080/1024533021000037162. PMID: 12850817

Prognosis

Goschzik T, Mynarek M, Doerner E, Schenk A, Spier I, Warmuth-Metz M, Bison B, Obrecht D, Struve N, Kortmann RD, Schmid M, Aretz S, Rutkowski S, Pietsch T
Acta Neuropathol 2022 Dec;144(6):1143-1156. Epub 2022 Oct 1 doi: 10.1007/s00401-022-02505-5. PMID: 36181537Free PMC Article
Goschzik T, Zur Muehlen A, Doerner E, Waha A, Friedrich C, Hau P, Pietsch T
J Neuropathol Exp Neurol 2021 Apr 16;80(5):419-430. doi: 10.1093/jnen/nlab020. PMID: 33870422
Cambruzzi E
Childs Nerv Syst 2018 May;34(5):809-815. Epub 2018 Mar 26 doi: 10.1007/s00381-018-3765-2. PMID: 29582169
Trubicka J, Szperl M, Grajkowska W, Karkucińska-Więckowska A, Tarasińska M, Falana K, Dembowska-Bagińska B, Łastowska M
Folia Neuropathol 2016;54(1):23-30. doi: 10.5114/fn.2016.58912. PMID: 27179218
Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, Zhukova N, Vanner R, Kros JM, French PJ, Van Meir EG, Vibhakar R, Zitterbart K, Chan JA, Bognár L, Klekner A, Lach B, Jung S, Saad AG, Liau LM, Albrecht S, Zollo M, Cooper MK, Thompson RC, Delattre OO, Bourdeaut F, Doz FF, Garami M, Hauser P, Carlotti CG, Van Meter TE, Massimi L, Fults D, Pomeroy SL, Kumabe T, Ra YS, Leonard JR, Elbabaa SK, Mora J, Rubin JB, Cho YJ, McLendon RE, Bigner DD, Eberhart CG, Fouladi M, Wechsler-Reya RJ, Faria CC, Croul SE, Huang A, Bouffet E, Hawkins CE, Dirks PB, Weiss WA, Schüller U, Pollack IF, Rutkowski S, Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grajkowska WA, Kim SK, Rutka JT, Malkin D, Tabori U, Pfister SM, Korshunov A, von Deimling A, Taylor MD
Acta Neuropathol 2013 Dec;126(6):917-29. Epub 2013 Oct 31 doi: 10.1007/s00401-013-1198-2. PMID: 24174164Free PMC Article

Clinical prediction guides

Roth JJ, Santi M, Rorke-Adams LB, Harding BN, Busse TM, Tooke LS, Biegel JA
Cancer Genet 2014 Apr;207(4):111-23. Epub 2014 Mar 15 doi: 10.1016/j.cancergen.2014.03.002. PMID: 24767714Free PMC Article
Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, Zhukova N, Vanner R, Kros JM, French PJ, Van Meir EG, Vibhakar R, Zitterbart K, Chan JA, Bognár L, Klekner A, Lach B, Jung S, Saad AG, Liau LM, Albrecht S, Zollo M, Cooper MK, Thompson RC, Delattre OO, Bourdeaut F, Doz FF, Garami M, Hauser P, Carlotti CG, Van Meter TE, Massimi L, Fults D, Pomeroy SL, Kumabe T, Ra YS, Leonard JR, Elbabaa SK, Mora J, Rubin JB, Cho YJ, McLendon RE, Bigner DD, Eberhart CG, Fouladi M, Wechsler-Reya RJ, Faria CC, Croul SE, Huang A, Bouffet E, Hawkins CE, Dirks PB, Weiss WA, Schüller U, Pollack IF, Rutkowski S, Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grajkowska WA, Kim SK, Rutka JT, Malkin D, Tabori U, Pfister SM, Korshunov A, von Deimling A, Taylor MD
Acta Neuropathol 2013 Dec;126(6):917-29. Epub 2013 Oct 31 doi: 10.1007/s00401-013-1198-2. PMID: 24174164Free PMC Article
Bliek BJ, Steegers-Theunissen RP, Douben H, Lindemans J, Steegers EA, de Klein A
Mutat Res 2012 Jan 24;741(1-2):76-80. Epub 2011 Nov 25 doi: 10.1016/j.mrgentox.2011.10.015. PMID: 22138420
Rasillo A, Tabernero MD, Sánchez ML, Pérez de Andrés M, Martín Ayuso M, Hernández J, Moro MJ, Fernández-Calvo J, Sayagués JM, Bortoluci A, San Miguel JF, Orfao A
Cancer 2003 Feb 1;97(3):601-9. doi: 10.1002/cncr.11100. PMID: 12548602
Ohyashiki K, Yoshida MA, Gibas LM, Ohyashiki JH, Katsunuma H, Ryan DH, Rowe J, Sandberg AA
Cancer Genet Cytogenet 1986 Apr 15;21(4):287-95. doi: 10.1016/0165-4608(86)90207-4. PMID: 3456822

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