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Bone marrow hyperplasia

MedGen UID:
2700
•Concept ID:
C0005959
•
Pathologic Function
Synonyms: Bone Marrow Hyperplasia; Hematopoietic cell proliferation; Hyperplasia of Bone Marrow; Marrow Hyperplasia
SNOMED CT: Bone marrow hyperplasia (10138007); Hematopoietic cell proliferation (10138007)

Definition

Increase in the number of hematopoietic cells in the bone marrow. It may involve all or individual hematopoietic cell lines. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow hyperplasia

Professional guidelines

PubMed

Chronic neutrophilic leukemia: 2022 update on diagnosis, genomic landscape, prognosis, and management.
Szuber N, Elliott M, Tefferi A
Am J Hematol 2022 Apr;97(4):491-505. Epub 2022 Feb 9 doi: 10.1002/ajh.26481. PMID: 35089603
Chronic neutrophilic leukemia: 2020 update on diagnosis, molecular genetics, prognosis, and management.
Szuber N, Elliott M, Tefferi A
Am J Hematol 2020 Feb;95(2):212-224. Epub 2019 Dec 30 doi: 10.1002/ajh.25688. PMID: 31769070
Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.
Agarwal S, Mayer L
Clin Gastroenterol Hepatol 2013 Sep;11(9):1050-63. Epub 2013 Mar 13 doi: 10.1016/j.cgh.2013.02.024. PMID: 23501398Free PMC Article

Recent clinical studies

Etiology

FDG-PET vs. chemical shift MR imaging in differentiating intertrabecular metastasis from hematopoietic bone marrow hyperplasia.
Oki N, Ikebe Y, Koike H, Ideguchi R, Niino D, Uetani M
Jpn J Radiol 2021 Nov;39(11):1077-1085. Epub 2021 Jun 8 doi: 10.1007/s11604-021-01149-x. PMID: 34101119Free PMC Article
Impact of bone disease and pain in thalassemia.
Piga A
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):272-277. doi: 10.1182/asheducation-2017.1.272. PMID: 29222266Free PMC Article
Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA
Semin Nucl Med 2017 Jul;47(4):322-351. Epub 2017 Apr 12 doi: 10.1053/j.semnuclmed.2017.02.004. PMID: 28583274
The Erlenmeyer flask bone deformity in the skeletal dysplasias.
Faden MA, Krakow D, Ezgu F, Rimoin DL, Lachman RS
Am J Med Genet A 2009 Jun;149A(6):1334-45. doi: 10.1002/ajmg.a.32253. PMID: 19444897Free PMC Article
Verification of extensive bone marrow hyperplasia using magnetic resonance imaging.
Marmulla R, Mühling J
J Oral Maxillofac Surg 2007 Aug;65(8):1590-4. doi: 10.1016/j.joms.2006.10.014. PMID: 17656288

Diagnosis

FDG-PET vs. chemical shift MR imaging in differentiating intertrabecular metastasis from hematopoietic bone marrow hyperplasia.
Oki N, Ikebe Y, Koike H, Ideguchi R, Niino D, Uetani M
Jpn J Radiol 2021 Nov;39(11):1077-1085. Epub 2021 Jun 8 doi: 10.1007/s11604-021-01149-x. PMID: 34101119Free PMC Article
Impact of bone disease and pain in thalassemia.
Piga A
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):272-277. doi: 10.1182/asheducation-2017.1.272. PMID: 29222266Free PMC Article
Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA
Semin Nucl Med 2017 Jul;47(4):322-351. Epub 2017 Apr 12 doi: 10.1053/j.semnuclmed.2017.02.004. PMID: 28583274
Verification of extensive bone marrow hyperplasia using magnetic resonance imaging.
Marmulla R, Mühling J
J Oral Maxillofac Surg 2007 Aug;65(8):1590-4. doi: 10.1016/j.joms.2006.10.014. PMID: 17656288
Bone marrow leukemias and lymphoproliferative disorders: scanning electron microscope diagnosis.
Terzakis JA, Taskin M
Ultrastruct Pathol 2002 May-Jun;26(3):143-52. doi: 10.1080/01913120290076801. PMID: 12184372

Therapy

Influence of the degree of donor bone marrow hyperplasia on patient clinical outcomes after allogeneic hematopoietic stem cell transplantation.
Tang F, Mo X, Zhang X, Wang Y, Yan C, Chen Y, Chen H, Han W, Chen Y, Wang F, Wang J, Sun Y, Zhang Y, Liu K, Huang X, Xu L
Sci China Life Sci 2020 Jan;63(1):138-147. Epub 2019 Aug 13 doi: 10.1007/s11427-018-9509-y. PMID: 31432375
Splenic Enlargement and Bone Marrow Hyperplasia in Patients Receiving Trastuzumab-Emtansine for Metastatic Breast Cancer.
Kosmin M, Makris A, Jawad N, Woolf D, Miles D, Padhani AR
Target Oncol 2017 Apr;12(2):229-234. doi: 10.1007/s11523-017-0477-6. PMID: 28110417
2017 Clinical trials update in new treatments of β-thalassemia.
Makis A, Hatzimichael E, Papassotiriou I, Voskaridou E
Am J Hematol 2016 Nov;91(11):1135-1145. doi: 10.1002/ajh.24530. PMID: 27502996
Bone age progression during five years of substitutive therapy for the induction of puberty in thalassemic girls--effects on height and sitting height.
Filosa A, Di Maio S, Lamba M, Baron I, Saviano A, Esposito G
J Pediatr Endocrinol Metab 1999 Jul-Aug;12(4):525-30. doi: 10.1515/jpem.1999.12.4.525. PMID: 10417968
Bone density and metabolism in thalassaemia.
Lala R, Chiabotto P, Di Stefano M, Isaia GC, Garofalo F, Piga A
J Pediatr Endocrinol Metab 1998;11 Suppl 3:785-90. PMID: 10091147

Prognosis

Prediction of Early Treatment Response in Multiple Myeloma Using MY-RADS Total Burden Score, ADC, and Fat Fraction From Whole-Body MRI: Impact of Anemia on Predictive Performance.
Dong H, Huang W, Ji X, Huang L, Zou D, Hao M, Deng S, Shen Z, Lu X, Wang J, Song Z, Zhang X, Xue H, Xia S
AJR Am J Roentgenol 2022 Feb;218(2):310-319. Epub 2021 Sep 15 doi: 10.2214/AJR.21.26534. PMID: 34523949
Circulating extracellular vesicles induce monocyte dysfunction and are associated with sepsis and high mortality in cirrhosis.
Baweja S, Bihari C, Negi P, Thangariyal S, Kumari A, Lal D, Maheshwari D, Singh Maras J, Nautiyal N, Kumar G, Kumar A, Trehanpati N, Mehta G, Kumar Chaudhary A, Maiwall R, Kumar Sarin S
Liver Int 2021 Jul;41(7):1614-1628. Epub 2021 Apr 1 doi: 10.1111/liv.14875. PMID: 33713381
Chronic Hemolysis May Adversely Affect Skeletal Health. A Cross-Sectional Study of a Pediatric Population.
Doulgeraki A, Fragodimitri C, Athanasopoulou H, Drakaki K, Karabatsos F, Schiza V, Yousef J, Monopolis I, Chatziliami A
Hemoglobin 2021 Jan;45(1):30-36. Epub 2021 Feb 8 doi: 10.1080/03630269.2021.1879129. PMID: 33557624
Influence of the degree of donor bone marrow hyperplasia on patient clinical outcomes after allogeneic hematopoietic stem cell transplantation.
Tang F, Mo X, Zhang X, Wang Y, Yan C, Chen Y, Chen H, Han W, Chen Y, Wang F, Wang J, Sun Y, Zhang Y, Liu K, Huang X, Xu L
Sci China Life Sci 2020 Jan;63(1):138-147. Epub 2019 Aug 13 doi: 10.1007/s11427-018-9509-y. PMID: 31432375
Serum levels of erythropoietin and soluble transferrin receptor in the course of pregnancy in non beta thalassemic and beta thalassemic women.
Bianco I, Mastropietro F, D'Asero C, Graziani B, Piergrossi P, Mezzabotta M, Modiano G
Haematologica 2000 Sep;85(9):902-7. PMID: 10980626

Clinical prediction guides

Chronic Hemolysis May Adversely Affect Skeletal Health. A Cross-Sectional Study of a Pediatric Population.
Doulgeraki A, Fragodimitri C, Athanasopoulou H, Drakaki K, Karabatsos F, Schiza V, Yousef J, Monopolis I, Chatziliami A
Hemoglobin 2021 Jan;45(1):30-36. Epub 2021 Feb 8 doi: 10.1080/03630269.2021.1879129. PMID: 33557624
Influence of the degree of donor bone marrow hyperplasia on patient clinical outcomes after allogeneic hematopoietic stem cell transplantation.
Tang F, Mo X, Zhang X, Wang Y, Yan C, Chen Y, Chen H, Han W, Chen Y, Wang F, Wang J, Sun Y, Zhang Y, Liu K, Huang X, Xu L
Sci China Life Sci 2020 Jan;63(1):138-147. Epub 2019 Aug 13 doi: 10.1007/s11427-018-9509-y. PMID: 31432375
Splenic Enlargement and Bone Marrow Hyperplasia in Patients Receiving Trastuzumab-Emtansine for Metastatic Breast Cancer.
Kosmin M, Makris A, Jawad N, Woolf D, Miles D, Padhani AR
Target Oncol 2017 Apr;12(2):229-234. doi: 10.1007/s11523-017-0477-6. PMID: 28110417
Functional roles of thrombopoietin-c-mpl system in essential thrombocythemia.
Matsumura I, Horikawa Y, Kanakura Y
Leuk Lymphoma 1999 Jan;32(3-4):351-8. doi: 10.3109/10428199909167396. PMID: 10037033
Bone density and metabolism in thalassaemia.
Lala R, Chiabotto P, Di Stefano M, Isaia GC, Garofalo F, Piga A
J Pediatr Endocrinol Metab 1998;11 Suppl 3:785-90. PMID: 10091147

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