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Bone Neoplasm

MedGen UID:
2701
•Concept ID:
C0005967
•
Neoplastic Process
Synonyms: Bone Neoplasms; Neoplasm, Bone; Neoplasms, Bone
SNOMED CT: Bone tumor (115239009); Neoplasm of bone (126537000)

Definition

A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Neoplasm

Professional guidelines

PubMed

Metastatic giant cell tumour of bone: a narrative review of management options and approaches.
Xu R, Choong PFM
ANZ J Surg 2022 Apr;92(4):691-696. Epub 2022 Feb 10 doi: 10.1111/ans.17520. PMID: 35143093Free PMC Article
Facial Schwannoma Management Outcomes: A Systematic Review of the Literature.
Bartindale M, Heiferman J, Joyce C, Anderson D, Leonetti J
Otolaryngol Head Neck Surg 2020 Aug;163(2):293-301. Epub 2020 Mar 31 doi: 10.1177/0194599820913639. PMID: 32228141
Atraumatic vertebral compression fractures: differential diagnosis between benign osteoporotic and malignant fractures by MRI.
Cicala D, Briganti F, Casale L, Rossi C, Cagini L, Cesarano E, Brunese L, Giganti M
Musculoskelet Surg 2013 Aug;97 Suppl 2:S169-79. Epub 2013 Aug 15 doi: 10.1007/s12306-013-0277-9. PMID: 23949939

Recent clinical studies

Etiology

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations.
Pekarek L, De la Torre-Escuredo B, Fraile-Martinez O, García-Montero C, Saez MA, Cobo-Prieto D, Guijarro LG, Saz JV, De Castro-Martinez P, Torres-Carranza D, Pekarek T, Carrera AC, Alvarez-Mon M, Ortega MA
Int J Mol Sci 2022 Nov 29;23(23) doi: 10.3390/ijms232314939. PMID: 36499267Free PMC Article
Clinical differences between central and peripheral chondrosarcomas.
Laitinen MK, Evans S, Stevenson J, Sumathi V, Kask G, Jeys LM, Parry MC
Bone Joint J 2021 May;103-B(5):984-990. doi: 10.1302/0301-620X.103B5.BJJ-2020-1082.R2. PMID: 33934657
Quantitative bone SPECT/CT applications for primary bone neoplasms.
Kitajima K, Futani H, Komoto H, Tsuchitani T, Takahashi Y, Tachibana T, Yamakado K
Hell J Nucl Med 2021 Jan-Apr;24(1):36-44. Epub 2021 Apr 20 doi: 10.1967/s002449912304. PMID: 33866337
Whole-body MRI of bone marrow: A review.
Hynes JP, Hughes N, Cunningham P, Kavanagh EC, Eustace SJ
J Magn Reson Imaging 2019 Dec;50(6):1687-1701. Epub 2019 Apr 23 doi: 10.1002/jmri.26759. PMID: 31016800
Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation.
Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785

Diagnosis

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma.
Barani M, Mukhtar M, Rahdar A, Sargazi S, Pandey S, Kang M
Biosensors (Basel) 2021 Feb 20;11(2) doi: 10.3390/bios11020055. PMID: 33672770Free PMC Article
Skeletal Survey in Multiple Myeloma: Role of Imaging.
Spinnato P, Filonzi G, Conficoni A, Facchini G, Ponti F, Sambri A, De Paolis M, Cavo M, Salizzoni E, Nanni C
Curr Med Imaging 2021;17(8):956-965. doi: 10.2174/1573405617666210126155129. PMID: 33573573
MR Imaging of Osteoid Osteoma: Pearls and Pitfalls.
French J, Epelman M, Johnson CM, Stinson Z, Meyers AB
Semin Ultrasound CT MR 2020 Oct;41(5):488-497. Epub 2020 May 28 doi: 10.1053/j.sult.2020.05.013. PMID: 32980095
Multiparametric MR Imaging of Benign and Malignant Bone Lesions.
Tang H, Ahlawat S, Fayad LM
Magn Reson Imaging Clin N Am 2018 Nov;26(4):559-569. doi: 10.1016/j.mric.2018.06.010. PMID: 30316467
Primary Tumors of the Foot and Ankle.
Kennedy JG, Ross KA, Smyth NA, Hogan MV, Murawski CD
Foot Ankle Spec 2016 Feb;9(1):58-68. Epub 2015 Dec 7 doi: 10.1177/1938640015620634. PMID: 26644034

Therapy

Metastatic giant cell tumour of bone: a narrative review of management options and approaches.
Xu R, Choong PFM
ANZ J Surg 2022 Apr;92(4):691-696. Epub 2022 Feb 10 doi: 10.1111/ans.17520. PMID: 35143093Free PMC Article
Clinicopathologic and molecular features of denosumab-treated giant cell tumour of bone (GCTB): Analysis of 21 cases.
Yang L, Zhang H, Zhang X, Tang Y, Wu Z, Wang Y, Huang H, Fu X, Liu J, Hogendoorn PCW, Cheng H
Ann Diagn Pathol 2022 Apr;57:151882. Epub 2021 Dec 23 doi: 10.1016/j.anndiagpath.2021.151882. PMID: 34995868
Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma.
Barani M, Mukhtar M, Rahdar A, Sargazi S, Pandey S, Kang M
Biosensors (Basel) 2021 Feb 20;11(2) doi: 10.3390/bios11020055. PMID: 33672770Free PMC Article
Oral plasmablastic lymphoma: A case report.
Zizzo M, Zanelli M, Martiniani R, Sanguedolce F, De Marco L, Martino G, Parente P, Annessi V, Manzini L, Ascani S
Medicine (Baltimore) 2020 Sep 25;99(39):e22335. doi: 10.1097/MD.0000000000022335. PMID: 32991445Free PMC Article
Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation.
Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785

Prognosis

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations.
Pekarek L, De la Torre-Escuredo B, Fraile-Martinez O, García-Montero C, Saez MA, Cobo-Prieto D, Guijarro LG, Saz JV, De Castro-Martinez P, Torres-Carranza D, Pekarek T, Carrera AC, Alvarez-Mon M, Ortega MA
Int J Mol Sci 2022 Nov 29;23(23) doi: 10.3390/ijms232314939. PMID: 36499267Free PMC Article
Clinical differences between central and peripheral chondrosarcomas.
Laitinen MK, Evans S, Stevenson J, Sumathi V, Kask G, Jeys LM, Parry MC
Bone Joint J 2021 May;103-B(5):984-990. doi: 10.1302/0301-620X.103B5.BJJ-2020-1082.R2. PMID: 33934657
Skeletal Survey in Multiple Myeloma: Role of Imaging.
Spinnato P, Filonzi G, Conficoni A, Facchini G, Ponti F, Sambri A, De Paolis M, Cavo M, Salizzoni E, Nanni C
Curr Med Imaging 2021;17(8):956-965. doi: 10.2174/1573405617666210126155129. PMID: 33573573
Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation.
Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785
Osteosarcoma of the jaw bones.
Chindia ML
Oral Oncol 2001 Oct;37(7):545-7. doi: 10.1016/s1368-8375(00)00129-9. PMID: 11564573

Clinical prediction guides

GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics.
Toland AMS, Lam SW, Varma S, Wang A, Howitt BE, Kunder CA, Kerr DA, Szuhai K, Bovée JVMG, Charville GW
Am J Surg Pathol 2022 Oct 1;46(10):1407-1414. Epub 2022 Jun 1 doi: 10.1097/PAS.0000000000001921. PMID: 35650682Free PMC Article
Sclerosing epithelioid fibrosarcoma of bone: morphological, immunophenotypical, and molecular findings of 9 cases.
Kosemehmetoglu K, Ardic F, Kilpatrick SE, Aydingoz U, Sumathi VP, Michal M
Virchows Arch 2021 Apr;478(4):767-777. Epub 2020 Oct 21 doi: 10.1007/s00428-020-02953-y. PMID: 33084978
Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes.
Sand LG, Szuhai K, Hogendoorn PC
Int J Mol Sci 2015 Jul 16;16(7):16176-215. doi: 10.3390/ijms160716176. PMID: 26193259Free PMC Article
Atraumatic vertebral compression fractures: differential diagnosis between benign osteoporotic and malignant fractures by MRI.
Cicala D, Briganti F, Casale L, Rossi C, Cagini L, Cesarano E, Brunese L, Giganti M
Musculoskelet Surg 2013 Aug;97 Suppl 2:S169-79. Epub 2013 Aug 15 doi: 10.1007/s12306-013-0277-9. PMID: 23949939
Osteosarcoma of the jaw bones.
Chindia ML
Oral Oncol 2001 Oct;37(7):545-7. doi: 10.1016/s1368-8375(00)00129-9. PMID: 11564573

Recent systematic reviews

Facial Schwannoma Management Outcomes: A Systematic Review of the Literature.
Bartindale M, Heiferman J, Joyce C, Anderson D, Leonetti J
Otolaryngol Head Neck Surg 2020 Aug;163(2):293-301. Epub 2020 Mar 31 doi: 10.1177/0194599820913639. PMID: 32228141

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