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Monosomy 17

MedGen UID:
270785
•Concept ID:
C1513480
•
Cell or Molecular Dysfunction

Definition

A chromosomal abnormality consisting of the absence of one of the copies of chromosome 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonosomy 17

Professional guidelines

PubMed

Evaluation of genetic status of HER-2/neu and aneusomy 17 by fluorescence in situ hybridization and comparison with immunohistochemistry assay from Indian breast cancer patients.
Kokate P, Sawaimoon S, Bhatia S, Mandava S
Genet Test Mol Biomarkers 2012 Apr;16(4):239-45. Epub 2011 Oct 24 doi: 10.1089/gtmb.2011.0125. PMID: 22023243
HER2 gene-amplified breast cancers with monosomy of chromosome 17 are poorly responsive to trastuzumab-based treatment.
Risio M, Casorzo L, Redana S, Montemurro F
Oncol Rep 2005 Feb;13(2):305-9. PMID: 15643516

Recent clinical studies

Etiology

Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia.
Yoshida S, Onozawa M, Miyashita N, Kimura H, Takahashi S, Yokoyama S, Matsukawa T, Hirabayashi S, Mori A, Hidaka D, Minauchi K, Shigematsu A, Hashiguchi J, Igarashi T, Kakinoki Y, Tsutsumi Y, Ibata M, Kobayashi H, Haseyama Y, Fujimoto K, Ishihara T, Sakai H, Ota S, Kondo T, Teshima T
Int J Hematol 2023 Apr;117(4):544-552. Epub 2022 Dec 26 doi: 10.1007/s12185-022-03522-6. PMID: 36572814
Differential characteristics of TP53 alterations in pure erythroid leukemia arising after exposure to cytotoxic therapy.
Tashakori M, Wang W, Kadia TM, Daver NG, Montalban-Bravo G, Loghavi S, Wang SA, Medeiros LJ, Ravandi F, Khoury JD
Leuk Res 2022 Jul;118:106860. Epub 2022 May 17 doi: 10.1016/j.leukres.2022.106860. PMID: 35636055
"Double-hit" chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain.
Chapiro E, Lesty C, Gabillaud C, Durot E, Bouzy S, Armand M, Le Garff-Tavernier M, Bougacha N, Struski S, Bidet A, Laharanne E, Barin C, Veronese L, Prié N, Eclache V, Gaillard B, Michaux L, Lefebvre C, Gaillard JB, Terré C, Penther D, Bastard C, Nadal N, Fert-Ferrer S, Auger N, Godon C, Sutton L, Tournilhac O, Susin SA, Nguyen-Khac F; GroupeFrancophone de Cytogénétique Hématologique(GFCH) and the French Innovative Leukemia Organization (FILO) group
Am J Hematol 2018 Mar;93(3):375-382. Epub 2017 Dec 18 doi: 10.1002/ajh.24990. PMID: 29194741
Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials.
Strickland SA, Sun Z, Ketterling RP, Cherry AM, Cripe LD, Dewald G, Fernandez HF, Hicks GA, Higgins RR, Lazarus HM, Litzow MR, Luger SM, Paietta EM, Rowe JM, Vance GH, Wiernik P, Wiktor AE, Zhang Y, Tallman MS; ECOG-ACRIN Cancer Research Group
Leuk Res 2017 Aug;59:55-64. Epub 2017 May 12 doi: 10.1016/j.leukres.2017.05.010. PMID: 28551161Free PMC Article
The non-random distribution of point mutations in leukaemia and myelodysplasia--a possible pointer to their aetiology.
Parry TE
Leuk Res 1997 Jun;21(6):559-74. doi: 10.1016/s0145-2126(97)83221-3. PMID: 9279367

Diagnosis

Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia.
Yoshida S, Onozawa M, Miyashita N, Kimura H, Takahashi S, Yokoyama S, Matsukawa T, Hirabayashi S, Mori A, Hidaka D, Minauchi K, Shigematsu A, Hashiguchi J, Igarashi T, Kakinoki Y, Tsutsumi Y, Ibata M, Kobayashi H, Haseyama Y, Fujimoto K, Ishihara T, Sakai H, Ota S, Kondo T, Teshima T
Int J Hematol 2023 Apr;117(4):544-552. Epub 2022 Dec 26 doi: 10.1007/s12185-022-03522-6. PMID: 36572814
Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course.
Put N, Van Roosbroeck K, Konings P, Meeus P, Brusselmans C, Rack K, Gervais C, Nguyen-Khac F, Chapiro E, Radford-Weiss I, Struski S, Dastugue N, Gachard N, Lefebvre C, Barin C, Eclache V, Fert-Ferrer S, Laibe S, Mozziconacci MJ, Quilichini B, Poirel HA, Wlodarska I, Hagemeijer A, Moreau Y, Vandenberghe P, Michaux L; BCGHo and the GFCH
Ann Hematol 2012 Jun;91(6):863-73. Epub 2011 Dec 30 doi: 10.1007/s00277-011-1393-y. PMID: 22205151
Evaluation of genetic status of HER-2/neu and aneusomy 17 by fluorescence in situ hybridization and comparison with immunohistochemistry assay from Indian breast cancer patients.
Kokate P, Sawaimoon S, Bhatia S, Mandava S
Genet Test Mol Biomarkers 2012 Apr;16(4):239-45. Epub 2011 Oct 24 doi: 10.1089/gtmb.2011.0125. PMID: 22023243
Numerical abnormalities of chromosomes 17 and 18 in sporadic colorectal cancer: Incidence and correlation with clinical and biological findings and the prognosis of the disease.
Garcia J, Duran A, Tabernero MD, Garcia Plaza A, Flores Corral T, Najera ML, Gomez-Alonso A, Orfao A
Cytometry B Clin Cytom 2003 Jan;51(1):14-20. doi: 10.1002/cyto.b.10006. PMID: 12500293
Chromosomal aneusomies detected by fluorescent in situ hybridization analysis in clinically localized prostate carcinoma.
Brown JA, Alcaraz A, Takahashi S, Persons DL, Lieber MM, Jenkins RB
J Urol 1994 Oct;152(4):1157-62. doi: 10.1016/s0022-5347(17)32527-2. PMID: 8072085

Therapy

Monosomy 17 in potentially curable HER2-amplified breast cancer: prognostic and predictive impact.
Page DB, Wen H, Brogi E, Dure D, Ross D, Spinelli KJ, Patil S, Norton L, Hudis C, McArthur HL
Breast Cancer Res Treat 2018 Jan;167(2):547-554. Epub 2017 Oct 6 doi: 10.1007/s10549-017-4520-1. PMID: 28986743Free PMC Article
Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials.
Strickland SA, Sun Z, Ketterling RP, Cherry AM, Cripe LD, Dewald G, Fernandez HF, Hicks GA, Higgins RR, Lazarus HM, Litzow MR, Luger SM, Paietta EM, Rowe JM, Vance GH, Wiernik P, Wiktor AE, Zhang Y, Tallman MS; ECOG-ACRIN Cancer Research Group
Leuk Res 2017 Aug;59:55-64. Epub 2017 May 12 doi: 10.1016/j.leukres.2017.05.010. PMID: 28551161Free PMC Article
The non-random distribution of point mutations in leukaemia and myelodysplasia--a possible pointer to their aetiology.
Parry TE
Leuk Res 1997 Jun;21(6):559-74. doi: 10.1016/s0145-2126(97)83221-3. PMID: 9279367
Chromosomal aneusomies detected by fluorescent in situ hybridization analysis in clinically localized prostate carcinoma.
Brown JA, Alcaraz A, Takahashi S, Persons DL, Lieber MM, Jenkins RB
J Urol 1994 Oct;152(4):1157-62. doi: 10.1016/s0022-5347(17)32527-2. PMID: 8072085
Translocations (5;17) and (7;17) in patients with de novo or therapy-related myelodysplastic syndromes or acute nonlymphocytic leukemia. A possible association with acquired pseudo-Pelger-Huët anomaly and small vacuolated granulocytes.
Laï JL, Zandecki M, Fenaux P, Le Baron F, Bauters F, Cosson A, Deminatti M
Cancer Genet Cytogenet 1990 Jun;46(2):173-83. doi: 10.1016/0165-4608(90)90102-g. PMID: 2340488

Prognosis

Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia.
Yoshida S, Onozawa M, Miyashita N, Kimura H, Takahashi S, Yokoyama S, Matsukawa T, Hirabayashi S, Mori A, Hidaka D, Minauchi K, Shigematsu A, Hashiguchi J, Igarashi T, Kakinoki Y, Tsutsumi Y, Ibata M, Kobayashi H, Haseyama Y, Fujimoto K, Ishihara T, Sakai H, Ota S, Kondo T, Teshima T
Int J Hematol 2023 Apr;117(4):544-552. Epub 2022 Dec 26 doi: 10.1007/s12185-022-03522-6. PMID: 36572814
Monosomy 17 in potentially curable HER2-amplified breast cancer: prognostic and predictive impact.
Page DB, Wen H, Brogi E, Dure D, Ross D, Spinelli KJ, Patil S, Norton L, Hudis C, McArthur HL
Breast Cancer Res Treat 2018 Jan;167(2):547-554. Epub 2017 Oct 6 doi: 10.1007/s10549-017-4520-1. PMID: 28986743Free PMC Article
Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials.
Strickland SA, Sun Z, Ketterling RP, Cherry AM, Cripe LD, Dewald G, Fernandez HF, Hicks GA, Higgins RR, Lazarus HM, Litzow MR, Luger SM, Paietta EM, Rowe JM, Vance GH, Wiernik P, Wiktor AE, Zhang Y, Tallman MS; ECOG-ACRIN Cancer Research Group
Leuk Res 2017 Aug;59:55-64. Epub 2017 May 12 doi: 10.1016/j.leukres.2017.05.010. PMID: 28551161Free PMC Article
Numerical abnormalities of chromosomes 17 and 18 in sporadic colorectal cancer: Incidence and correlation with clinical and biological findings and the prognosis of the disease.
Garcia J, Duran A, Tabernero MD, Garcia Plaza A, Flores Corral T, Najera ML, Gomez-Alonso A, Orfao A
Cytometry B Clin Cytom 2003 Jan;51(1):14-20. doi: 10.1002/cyto.b.10006. PMID: 12500293
The non-random distribution of point mutations in leukaemia and myelodysplasia--a possible pointer to their aetiology.
Parry TE
Leuk Res 1997 Jun;21(6):559-74. doi: 10.1016/s0145-2126(97)83221-3. PMID: 9279367

Clinical prediction guides

The frequency and clinical significance of centromere enumeration probe 17 alterations in human epidermal growth factor receptor 2 immunohistochemistry-equivocal invasive breast cancer.
Katayama A, Starczynski J, Toss MS, Shaaban AM, Provenzano E, Quinn CM, Callagy G, Purdie CA, Millican-Slater R, Purnell D, Chagla L, Oyama T, Pinder SE, Chan S, Ellis I, Lee AHS, Rakha EA
Histopathology 2022 Oct;81(4):511-519. Epub 2022 Aug 8 doi: 10.1111/his.14728. PMID: 35879836Free PMC Article
Monosomy 17 in potentially curable HER2-amplified breast cancer: prognostic and predictive impact.
Page DB, Wen H, Brogi E, Dure D, Ross D, Spinelli KJ, Patil S, Norton L, Hudis C, McArthur HL
Breast Cancer Res Treat 2018 Jan;167(2):547-554. Epub 2017 Oct 6 doi: 10.1007/s10549-017-4520-1. PMID: 28986743Free PMC Article
Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials.
Strickland SA, Sun Z, Ketterling RP, Cherry AM, Cripe LD, Dewald G, Fernandez HF, Hicks GA, Higgins RR, Lazarus HM, Litzow MR, Luger SM, Paietta EM, Rowe JM, Vance GH, Wiernik P, Wiktor AE, Zhang Y, Tallman MS; ECOG-ACRIN Cancer Research Group
Leuk Res 2017 Aug;59:55-64. Epub 2017 May 12 doi: 10.1016/j.leukres.2017.05.010. PMID: 28551161Free PMC Article
Molecular approach to common causes of female infertility.
Simpson JL
Best Pract Res Clin Obstet Gynaecol 2002 Oct;16(5):685-702. doi: 10.1053/beog.2002.0317. PMID: 12475548
Clonal cytogenetic abnormalities in Hodgkin's disease.
Ladanyi M, Parsa NZ, Offit K, Wachtel MS, Filippa DA, Jhanwar SC
Genes Chromosomes Cancer 1991 Jul;3(4):294-9. doi: 10.1002/gcc.2870030408. PMID: 1958594

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