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Thyroid gland mucoepidermoid carcinoma

MedGen UID:
270845
•Concept ID:
C1513721
•
Neoplastic Process
Synonyms: Mucoepidermoid Thyroid Carcinoma; mucoepidermoid thyroid carcinoma; Mucoepidermoid Thyroid Gland Carcinoma; mucoepidermoid thyroid gland carcinoma; Thyroid Gland Mucoepidermoid Carcinoma; thyroid gland mucoepidermoid carcinoma
 
Monarch Initiative: MONDO:0006463

Definition

A primary, low grade carcinoma of the thyroid gland composed of groups of squamoid and mucous cells, surrounded by fibrous tissue. Prominent cystic structures may be present. The clinical course is usually indolent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid gland mucoepidermoid carcinoma

Professional guidelines

PubMed

Surgery combined with postoperative (125) I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in pediatric patients.
Mao MH, Zheng L, Wang XM, Li H, Qin LZ, Zhang J, Han ZX, Zhang JG
Pediatr Blood Cancer 2017 Jan;64(1):57-63. Epub 2016 Aug 31 doi: 10.1002/pbc.26217. PMID: 27576792

Recent clinical studies

Etiology

Classification of head and neck cancer from PET images using convolutional neural networks.
Hellström H, Liedes J, Rainio O, Malaspina S, Kemppainen J, Klén R
Sci Rep 2023 Jun 29;13(1):10528. doi: 10.1038/s41598-023-37603-1. PMID: 37386289Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.
Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T
Am J Clin Pathol 2022 Jan 6;157(1):98-108. doi: 10.1093/ajcp/aqab099. PMID: 34508546Free PMC Article
Mucoepidermoid carcinoma post-radioactive iodine treatment of papillary thyroid carcinoma: unique presentation and putative etiologic association.
Saluja K, Butler RT, Pytynia KB, Zhao B, Karni RJ, Weber RS, El-Naggar AK
Hum Pathol 2017 Oct;68:189-192. Epub 2017 May 10 doi: 10.1016/j.humpath.2017.04.019. PMID: 28499545
Clear cell tumors of the salivary glands, jaws, and oral mucosa.
Maiorano E, Altini M, Favia G
Semin Diagn Pathol 1997 Aug;14(3):203-12. PMID: 9279976

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.
Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735Free PMC Article
Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Cytology of mucoepidermoid carcinoma of thyroid.
Purkait S, Sethy M, Parida PK, Mitra S
Cytopathology 2021 Nov;32(6):836-839. Epub 2021 Jun 24 doi: 10.1111/cyt.13018. PMID: 34086373
Salivary-Like Tumors of the Thyroid: A Comprehensive Review of Three Rare Carcinomas.
Chambers M, Nosé V, Sadow PM, Tafe LJ, Kerr DA
Head Neck Pathol 2021 Mar;15(1):212-224. Epub 2020 Jun 19 doi: 10.1007/s12105-020-01193-5. PMID: 32562215Free PMC Article

Therapy

Activating BRAF mutation in sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: two case reports and review of the literature.
Sukumar JS, Sukumar S, Purohit D, Welch BJ, Balani J, Yan S, Hathiramani SS
J Med Case Rep 2019 Dec 28;13(1):385. doi: 10.1186/s13256-019-2288-0. PMID: 31882020Free PMC Article
Mucoepidermoid carcinoma post-radioactive iodine treatment of papillary thyroid carcinoma: unique presentation and putative etiologic association.
Saluja K, Butler RT, Pytynia KB, Zhao B, Karni RJ, Weber RS, El-Naggar AK
Hum Pathol 2017 Oct;68:189-192. Epub 2017 May 10 doi: 10.1016/j.humpath.2017.04.019. PMID: 28499545
Surgery combined with postoperative (125) I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in pediatric patients.
Mao MH, Zheng L, Wang XM, Li H, Qin LZ, Zhang J, Han ZX, Zhang JG
Pediatr Blood Cancer 2017 Jan;64(1):57-63. Epub 2016 Aug 31 doi: 10.1002/pbc.26217. PMID: 27576792
Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature.
Singh A, Pandey KC, Pant NK
J Cancer Res Ther 2010 Jul-Sep;6(3):350-2. doi: 10.4103/0973-1482.73363. PMID: 21119274
A case report of mucoepidermoid carcinoma of the parotid gland developing after radioiodine therapy for thyroid carcinoma.
Rodríguez-Cuevas S, Ocampo LB
Eur J Surg Oncol 1995 Dec;21(6):692. doi: 10.1016/s0748-7983(95)96251-4. PMID: 8631425

Prognosis

Primary Thyroid Mucoepidermoid Carcinoma (MEC) Is Clinically, Prognostically, and Molecularly Different from Sclerosing MEC with Eosinophilia: A Multicenter and Integrated Study.
Le HT, Nguyen TPX, Hirokawa M, Katoh R, Mitsutake N, Matsuse M, Sako A, Kondo T, Vasan N, Kim YM, Liu Y, Hassell L, Kakudo K, Vuong HG
Endocr Pathol 2023 Mar;34(1):100-111. Epub 2022 Nov 17 doi: 10.1007/s12022-022-09741-1. PMID: 36394696
Synchronous mucoepidermoid carcinoma and papillary microcarcinomas of the thyroid gland.
Gupta KK, Garas G, Wilkes J, De M
BMJ Case Rep 2022 Nov 22;15(11) doi: 10.1136/bcr-2022-252117. PMID: 36414338Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Poorly differentiated mucoepidermoid carcinoma of the thyroid.
Lee K, Mirza O, Dobbs S, Jayaram S
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-236539. PMID: 33318270Free PMC Article
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.
Shah AA, La Fortune K, Miller C, Mills SE, Baloch Z, LiVolsi V, Dacic S, Mahaffey AL, Nikiforova M, Nikiforov YE, Seethala RR
Mod Pathol 2017 Mar;30(3):329-339. Epub 2016 Dec 2 doi: 10.1038/modpathol.2016.180. PMID: 27910944Free PMC Article

Clinical prediction guides

NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.
Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T
Am J Clin Pathol 2022 Jan 6;157(1):98-108. doi: 10.1093/ajcp/aqab099. PMID: 34508546Free PMC Article
Anaplastic thyroid carcinoma combined with sclerosing mucoepidermoid carcinoma with eosinophilia: A case report.
Mao R, Shi L, Yan W, Li W, Li B, Li X
Medicine (Baltimore) 2020 Oct 16;99(42):e22783. doi: 10.1097/MD.0000000000022783. PMID: 33080749Free PMC Article
Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland.
Niu X, Fang Q, Liu F
BMC Cancer 2019 May 3;19(1):417. doi: 10.1186/s12885-019-5637-x. PMID: 31053107Free PMC Article
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type.
Hirokawa M, Takada N, Abe H, Suzuki A, Higuchi M, Miya A, Hayashi T, Fukushima M, Kawahara A, Miyauchi A
Endocr J 2018 Apr 26;65(4):427-436. Epub 2018 Feb 8 doi: 10.1507/endocrj.EJ17-0462. PMID: 29415898
Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland in a male patient: a case report and literature review.
Lai CY, Chao TC, Lin JD, Hsueh C
Int J Clin Exp Pathol 2015;8(5):5947-51. Epub 2015 May 1 PMID: 26191325Free PMC Article

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