U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Preneoplastic Change

MedGen UID:
270998
•Concept ID:
C1514394
•
Cell or Molecular Dysfunction

Definition

Any alteration in cell state that promotes or renders a cell or cell population more vulnerable or prone to malignant conversion or transformation. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPreneoplastic Change

Professional guidelines

PubMed

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Preneoplastic and Primary Scrotal Cancer: Updates on Pathogenesis and Diagnostic Evaluation.
Zhu Y, Ye DW
Urol Clin North Am 2016 Nov;43(4):523-530. doi: 10.1016/j.ucl.2016.06.013. PMID: 27717438
Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance.
Liu KS, Wong IO, Leung WK
World J Gastroenterol 2016 Jan 21;22(3):1311-20. doi: 10.3748/wjg.v22.i3.1311. PMID: 26811668Free PMC Article

Recent clinical studies

Etiology

IMMUNOHISTOCHEMICAL EXPRESSION OF P16INK4a IN INFLAMMATORY, PRENEOPLASTIC AND NEOPLASTIC CERVICAL LESIONS.
Gajanin R, Gajanin Ž, Vujković Z, Gajanin V, Gojković Z, Ljubojević V
Med Pregl 2015 Mar-Apr;68(3-4):85-92. doi: 10.2298/mpns1504085g. PMID: 26214986
Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle.
Montironi R, Lopez-Beltran A, Cheng L, Galosi AB, Montorsi F, Scarpelli M
Eur Urol 2014 Oct;66(4):623-7. Epub 2014 Mar 4 doi: 10.1016/j.eururo.2014.02.054. PMID: 24631410
Occurrence of dysplasia and human papilloma virus typing in penile condylomas.
Baydar DE, Kulac I, Ozagari A, Guler Tezel G
Urology 2013 Jan;81(1):211.e9-15. Epub 2012 Nov 13 doi: 10.1016/j.urology.2012.09.009. PMID: 23153936
DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.
Feng Q, Hawes SE, Stern JE, Wiens L, Lu H, Dong ZM, Jordan CD, Kiviat NB, Vesselle H
Cancer Epidemiol Biomarkers Prev 2008 Mar;17(3):645-54. doi: 10.1158/1055-9965.EPI-07-2518. PMID: 18349282Free PMC Article
Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression.
Einspahr JG, Thomas TL, Saboda K, Nickolof BJ, Warneke J, Curiel-Lewandrowski C, Ranger-Moore J, Duckett L, Bangert J, Fruehauf JP, Alberts DS
Cancer 2007 Dec 1;110(11):2519-27. doi: 10.1002/cncr.23076. PMID: 17932890

Diagnosis

IMMUNOHISTOCHEMICAL EXPRESSION OF P16INK4a IN INFLAMMATORY, PRENEOPLASTIC AND NEOPLASTIC CERVICAL LESIONS.
Gajanin R, Gajanin Ž, Vujković Z, Gajanin V, Gojković Z, Ljubojević V
Med Pregl 2015 Mar-Apr;68(3-4):85-92. doi: 10.2298/mpns1504085g. PMID: 26214986
Significance of immunohistochemical expression of p16INK4a in the differentiation of inflammatory and preneoplastic cervical lesions.
Gajanin Ž, Vilendečić R, Zlojutro VE, Gajanin R, Budakov P
Srp Arh Celok Lek 2015 Jan-Feb;143(1-2):42-9. doi: 10.2298/sarh1502042g. PMID: 25845251
Abnormal cervicovaginal cytology, unsatisfactory colposcopy and the use of vaginal estrogen cream: an observational study of clinical outcomes for women in low estrogen states.
Richards A, Dalrymple C
J Obstet Gynaecol Res 2015 Mar;41(3):440-4. Epub 2014 Nov 5 doi: 10.1111/jog.12545. PMID: 25369987
Occurrence of dysplasia and human papilloma virus typing in penile condylomas.
Baydar DE, Kulac I, Ozagari A, Guler Tezel G
Urology 2013 Jan;81(1):211.e9-15. Epub 2012 Nov 13 doi: 10.1016/j.urology.2012.09.009. PMID: 23153936
Absence of the BRAF mutation in HBME1+ and CK19+ atypical cell clusters in Hashimoto thyroiditis: supportive evidence against preneoplastic change.
Nasr MR, Mukhopadhyay S, Zhang S, Katzenstein AL
Am J Clin Pathol 2009 Dec;132(6):906-12. doi: 10.1309/AJCPCGCZZ1OYF0IC. PMID: 19926583

Therapy

Abnormal cervicovaginal cytology, unsatisfactory colposcopy and the use of vaginal estrogen cream: an observational study of clinical outcomes for women in low estrogen states.
Richards A, Dalrymple C
J Obstet Gynaecol Res 2015 Mar;41(3):440-4. Epub 2014 Nov 5 doi: 10.1111/jog.12545. PMID: 25369987
Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium.
Yin H, He Q, Li T, Leong AS
Appl Immunohistochem Mol Morphol 2006 Sep;14(3):260-5. doi: 10.1097/00129039-200609000-00002. PMID: 16932015
The wages of warmth: changes in erythema ab igne.
Shahrad P, Marks R
Br J Dermatol 1977 Aug;97(2):179-86. doi: 10.1111/j.1365-2133.1977.tb15063.x. PMID: 911679

Prognosis

Abnormal cervicovaginal cytology, unsatisfactory colposcopy and the use of vaginal estrogen cream: an observational study of clinical outcomes for women in low estrogen states.
Richards A, Dalrymple C
J Obstet Gynaecol Res 2015 Mar;41(3):440-4. Epub 2014 Nov 5 doi: 10.1111/jog.12545. PMID: 25369987
Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle.
Montironi R, Lopez-Beltran A, Cheng L, Galosi AB, Montorsi F, Scarpelli M
Eur Urol 2014 Oct;66(4):623-7. Epub 2014 Mar 4 doi: 10.1016/j.eururo.2014.02.054. PMID: 24631410
Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression.
Einspahr JG, Thomas TL, Saboda K, Nickolof BJ, Warneke J, Curiel-Lewandrowski C, Ranger-Moore J, Duckett L, Bangert J, Fruehauf JP, Alberts DS
Cancer 2007 Dec 1;110(11):2519-27. doi: 10.1002/cncr.23076. PMID: 17932890
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
Zöchbauer-Müller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD
Cancer Res 2001 Jan 1;61(1):249-55. PMID: 11196170
Gastric cellular turnover and the development of atrophy after 31 years of follow-up: a case-control study.
Moss SF, Valle J, Abdalla AM, Wang S, Siurala M, Sipponen P
Am J Gastroenterol 1999 Aug;94(8):2109-14. doi: 10.1111/j.1572-0241.1999.01286.x. PMID: 10445536

Clinical prediction guides

Occurrence of dysplasia and human papilloma virus typing in penile condylomas.
Baydar DE, Kulac I, Ozagari A, Guler Tezel G
Urology 2013 Jan;81(1):211.e9-15. Epub 2012 Nov 13 doi: 10.1016/j.urology.2012.09.009. PMID: 23153936
Histomorphology of aberrant crypt foci in colorectal carcinoma.
Norlida AO, Phang KS
Malays J Pathol 2010 Dec;32(2):111-6. PMID: 21329182
Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia.
Tatematsu M, Tsukamoto T, Inada K
Cancer Sci 2003 Feb;94(2):135-41. doi: 10.1111/j.1349-7006.2003.tb01409.x. PMID: 12708487
Preneoplastic mammary tumor markers: Cripto and Amphiregulin are overexpressed in hyperplastic stages of tumor progression in transgenic mice.
Niemeyer CC, Spencer-Dene B, Wu JX, Adamson ED
Int J Cancer 1999 May 17;81(4):588-91. doi: 10.1002/(sici)1097-0215(19990517)81:4<588::aid-ijc14>3.0.co;2-i. PMID: 10225449
The wages of warmth: changes in erythema ab igne.
Shahrad P, Marks R
Br J Dermatol 1977 Aug;97(2):179-86. doi: 10.1111/j.1365-2133.1977.tb15063.x. PMID: 911679

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...