Polycythemia Vera, Polycythemic Phase

MedGen UID:: 271322
•Concept ID:: C1514197
•: Neoplastic Process

Synonym:

Polycythemia Vera, Polycythemic Stage

Definition

Polycythemia vera characterized by the proliferation of the erythroid, granulocytic, and megakaryocytic lineages. The peripheral blood shows excess of red blood cells, neutrophilia, and thrombocytosis. The bone marrow is hypercellular for the patient''s age. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPolycythemia Vera, Polycythemic Phase

Disorder by Site
- Hematopoietic and Lymphoid System Disorder
  - Hematologic disorder
    - Bone marrow disorder
      - Bone marrow neoplasm
        Acquired polycythemia vera
        Polycythemia Vera, Polycythemic Phase

Recent clinical studies

Etiology

Bone marrow findings in blast phase of polycythemia vera.

Hidalgo López JE, Carballo-Zarate A, Verstovsek S, Wang SA, Hu S, Li S, Xu J, Zuo W, Tang Z, Yin CC, Medeiros LJ, Bueso-Ramos CE, Tang G
Ann Hematol 2018 Mar;97(3):425-434. Epub 2017 Dec 28 doi: 10.1007/s00277-017-3211-7. PMID: 29285580

Characteristics and clinical significance of cytogenetic abnormalities in polycythemia vera.

Tang G, Hidalgo Lopez JE, Wang SA, Hu S, Ma J, Pierce S, Zuo W, Carballo-Zarate AA, Yin CC, Tang Z, Li S, Medeiros LJ, Verstovsek S, Bueso-Ramos CE
Haematologica 2017 Sep;102(9):1511-1518. Epub 2017 May 4 doi: 10.3324/haematol.2017.165795. PMID: 28473622 Free PMC Article

Neutrophilic leukocytosis in advanced stage polycythemia vera: hematopathologic features and prognostic implications.

Boiocchi L, Gianelli U, Iurlo A, Fend F, Bonzheim I, Cattaneo D, Knowles DM, Orazi A
Mod Pathol 2015 Nov;28(11):1448-57. Epub 2015 Sep 4 doi: 10.1038/modpathol.2015.100. PMID: 26336886

Polycythemia vera: new clinicopathologic perspectives.

Cao M, Olsen RJ, Zu Y
Arch Pathol Lab Med 2006 Aug;130(8):1126-32. doi: 10.5858/2006-130-1126-PV. PMID: 16879013

Thrombosis and bleeding in polycythemia vera and essential thrombocythemia: pathogenetic mechanisms and prevention.

Landolfi R, Cipriani MC, Novarese L
Best Pract Res Clin Haematol 2006;19(3):617-33. doi: 10.1016/j.beha.2005.07.011. PMID: 16781491

See all (12)

Diagnosis

Bone marrow findings in blast phase of polycythemia vera.

Characteristics and clinical significance of cytogenetic abnormalities in polycythemia vera.

Polycythemia vera: new clinicopathologic perspectives.

Cao M, Olsen RJ, Zu Y
Arch Pathol Lab Med 2006 Aug;130(8):1126-32. doi: 10.5858/2006-130-1126-PV. PMID: 16879013

Thrombosis and bleeding in polycythemia vera and essential thrombocythemia: pathogenetic mechanisms and prevention.

Landolfi R, Cipriani MC, Novarese L
Best Pract Res Clin Haematol 2006;19(3):617-33. doi: 10.1016/j.beha.2005.07.011. PMID: 16781491

Trisomy 1q in polycythemia vera and its relation to disease transition.

Swolin B, Weinfeld A, Westin J
Am J Hematol 1986 Jun;22(2):155-67. doi: 10.1002/ajh.2830220206. PMID: 3706291

See all (12)

Therapy

Aspirin for the control of platelet activation and prevention of thrombosis in essential thrombocythemia and polycythemia vera: current insights and rationale for future studies.

Landolfi R, Di Gennaro L, Novarese L, Patrono C
Semin Thromb Hemost 2006 Apr;32(3):251-9. doi: 10.1055/s-2006-939436. PMID: 16673279

See all (1)

Prognosis

Bone marrow findings in blast phase of polycythemia vera.

Characteristics and clinical significance of cytogenetic abnormalities in polycythemia vera.

Neutrophilic leukocytosis in advanced stage polycythemia vera: hematopathologic features and prognostic implications.

Boiocchi L, Gianelli U, Iurlo A, Fend F, Bonzheim I, Cattaneo D, Knowles DM, Orazi A
Mod Pathol 2015 Nov;28(11):1448-57. Epub 2015 Sep 4 doi: 10.1038/modpathol.2015.100. PMID: 26336886

Polycythemia vera: new clinicopathologic perspectives.

Cao M, Olsen RJ, Zu Y
Arch Pathol Lab Med 2006 Aug;130(8):1126-32. doi: 10.5858/2006-130-1126-PV. PMID: 16879013

Thrombosis and bleeding in polycythemia vera and essential thrombocythemia: pathogenetic mechanisms and prevention.

Landolfi R, Cipriani MC, Novarese L
Best Pract Res Clin Haematol 2006;19(3):617-33. doi: 10.1016/j.beha.2005.07.011. PMID: 16781491

See all (10)