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Rearrangement of 6q25

MedGen UID:
271462
•Concept ID:
C1514752
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRearrangement of 6q25

Recent clinical studies

Etiology

The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network.
Jiang P, Li Y, Poleshko A, Medvedeva V, Baulina N, Zhang Y, Zhou Y, Slater CM, Pellegrin T, Wasserman J, Lindy M, Efimov A, Daly M, Katz RA, Chen X
EBioMedicine 2017 Aug;22:28-43. Epub 2017 Jun 27 doi: 10.1016/j.ebiom.2017.06.024. PMID: 28687497Free PMC Article
Correlation between 6q25.3 deletion status and survival in pediatric intracranial ependymomas.
Monoranu CM, Huang B, Zangen IL, Rutkowski S, Vince GH, Gerber NU, Puppe B, Roggendorf W
Cancer Genet Cytogenet 2008 Apr 1;182(1):18-26. doi: 10.1016/j.cancergencyto.2007.12.008. PMID: 18328946
Cytogenetic patterns in ETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature.
Forestier E, Andersen MK, Autio K, Blennow E, Borgström G, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Rosenquist R, Swolin B, Johansson B; Nordic Society of Pediatric Hematology and Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Genes Chromosomes Cancer 2007 May;46(5):440-50. doi: 10.1002/gcc.20423. PMID: 17285576
Cytogenetic evolution patterns in non-Hodgkin's lymphoma.
Johansson B, Mertens F, Mitelman F
Blood 1995 Nov 15;86(10):3905-14. PMID: 7579360

Diagnosis

Cytogenetic patterns in ETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature.
Forestier E, Andersen MK, Autio K, Blennow E, Borgström G, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Rosenquist R, Swolin B, Johansson B; Nordic Society of Pediatric Hematology and Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Genes Chromosomes Cancer 2007 May;46(5):440-50. doi: 10.1002/gcc.20423. PMID: 17285576
Three cases with de novo 6q imbalance and variable prenatal phenotype.
Grati FR, Lalatta F, Turolla L, Cavallari U, Gentilin B, Rossella F, Cetin I, Antonazzo P, Bellotti M, Dulcetti F, Baldo D, Tenconi R, Simoni G, Miozzo M
Am J Med Genet A 2005 Jul 30;136(3):254-8. doi: 10.1002/ajmg.a.30837. PMID: 15957159
A dysmorphic newborn infant with a complex rearrangement involving chromosomes 2, 4, and 6 detected by fluorescence in situ hybridization (FISH).
Hoffman DJ, Punnett HH, Pyeritz RE
Am J Perinatol 2004 Feb;21(2):69-71. doi: 10.1055/s-2004-820514. PMID: 15017469
Aphidicolin-sensitive specific common fragile sites: a biomarker of exposure to pesticides.
Musio A, Sbrana I
Environ Mol Mutagen 1997;29(3):250-5. doi: 10.1002/(sici)1098-2280(1997)29:3<250::aid-em4>3.0.co;2-g. PMID: 9142167
Phenotypic characterization, karyotype analysis and in vitro tamoxifen sensitivity of new ER-negative vulvar carcinoma cell lines, UM-SCV-1A and UM-SCV-1B.
Grénman SE, Van Dyke DL, Worsham MJ, England B, McClatchey KD, Hopkins M, Babu VR, Grénman R, Carey TE
Int J Cancer 1990 May 15;45(5):920-7. doi: 10.1002/ijc.2910450524. PMID: 2335395

Therapy

Aphidicolin-sensitive specific common fragile sites: a biomarker of exposure to pesticides.
Musio A, Sbrana I
Environ Mol Mutagen 1997;29(3):250-5. doi: 10.1002/(sici)1098-2280(1997)29:3<250::aid-em4>3.0.co;2-g. PMID: 9142167

Prognosis

RUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case report.
Panagopoulos I, Torkildsen S, Gorunova L, Ulvmoen A, Tierens A, Zeller B, Heim S
Oncol Rep 2016 Nov;36(5):2481-2488. Epub 2016 Sep 22 doi: 10.3892/or.2016.5119. PMID: 27667292Free PMC Article
Correlation between 6q25.3 deletion status and survival in pediatric intracranial ependymomas.
Monoranu CM, Huang B, Zangen IL, Rutkowski S, Vince GH, Gerber NU, Puppe B, Roggendorf W
Cancer Genet Cytogenet 2008 Apr 1;182(1):18-26. doi: 10.1016/j.cancergencyto.2007.12.008. PMID: 18328946
Three cases with de novo 6q imbalance and variable prenatal phenotype.
Grati FR, Lalatta F, Turolla L, Cavallari U, Gentilin B, Rossella F, Cetin I, Antonazzo P, Bellotti M, Dulcetti F, Baldo D, Tenconi R, Simoni G, Miozzo M
Am J Med Genet A 2005 Jul 30;136(3):254-8. doi: 10.1002/ajmg.a.30837. PMID: 15957159

Clinical prediction guides

Cytogenetic and molecular analysis of 6q deletions in Burkitt's lymphoma cell lines.
Parsa NZ, Gaidano G, Mukherjee AB, Hauptschein RS, Lenoir G, Dalla-Favera R, Chaganti RS
Genes Chromosomes Cancer 1994 Jan;9(1):13-8. doi: 10.1002/gcc.2870090104. PMID: 7507695

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