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Tamoxifen-related endometrial lesion

MedGen UID:
271571
•Concept ID:
C1515212
•
Disease or Syndrome
Synonyms: Tamoxifen-Related Endometrial Disorder; tamoxifen-related endometrial disorder; Tamoxifen-Related Endometrial Lesion; tamoxifen-related endometrial lesion
 
Monarch Initiative: MONDO:0004414

Definition

A spectrum of endometrial abnormalities that occur in women who use tamoxifen to treat or prevent the development of breast cancer. These abnormalities include endometrial polyps, endometrial hyperplasia, and endometrial carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTamoxifen-related endometrial lesion

Professional guidelines

PubMed

Expression of the epidermal growth factor system in endometrial cancer after adjuvant tamoxifen treatment for breast cancer.
Androutsopoulos G, Adonakis G, Gkermpesi M, Gkogkos P, Ravazoula P, Kourounis G
Eur J Gynaecol Oncol 2006;27(5):490-4. PMID: 17139985
Combined modality treatment of locally advanced breast carcinoma in elderly patients or patients with severe comorbid conditions using tamoxifen as the primary therapy.
Hoff PM, Valero V, Buzdar AU, Singletary SE, Theriault RL, Booser D, Asmar L, Frye D, McNeese MD, Hortobagyi GN
Cancer 2000 May 1;88(9):2054-60. doi: 10.1002/(sici)1097-0142(20000501)88:9<2054::aid-cncr11>3.0.co;2-j. PMID: 10813717

Recent clinical studies

Etiology

Assessment of Tamoxifen-Related Endometrial Changes in Premenopausal Female Patients With Diffusion-Weighted Magnetic Resonance Imaging.
Abdel Razek AAK, Elkalla HMHR, Refky B, Elsergany A, Sakrana AA, Saleh G, Gadelhak BN
J Comput Assist Tomogr 2020 Jul/Aug;44(4):485-489. doi: 10.1097/RCT.0000000000001028. PMID: 32558766
Clinicopathologic study of 56 patients with endometrial cancer during or after adjuvant tamoxifen use for their breast cancers.
Hachisuga T, Saito T, Kigawa J, Ohwada M, Yamazawa K, Yasue A, Iwasaka T, Sugiyama T, Kita T, Nagai N
Gynecol Oncol 2004 Oct;95(1):139-44. doi: 10.1016/j.ygyno.2004.07.019. PMID: 15385123
Combined modality treatment of locally advanced breast carcinoma in elderly patients or patients with severe comorbid conditions using tamoxifen as the primary therapy.
Hoff PM, Valero V, Buzdar AU, Singletary SE, Theriault RL, Booser D, Asmar L, Frye D, McNeese MD, Hortobagyi GN
Cancer 2000 May 1;88(9):2054-60. doi: 10.1002/(sici)1097-0142(20000501)88:9<2054::aid-cncr11>3.0.co;2-j. PMID: 10813717
Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology.
Kennedy MM, Baigrie CF, Manek S
Int J Gynecol Pathol 1999 Apr;18(2):130-7. PMID: 10202670

Diagnosis

Assessment of Tamoxifen-Related Endometrial Changes in Premenopausal Female Patients With Diffusion-Weighted Magnetic Resonance Imaging.
Abdel Razek AAK, Elkalla HMHR, Refky B, Elsergany A, Sakrana AA, Saleh G, Gadelhak BN
J Comput Assist Tomogr 2020 Jul/Aug;44(4):485-489. doi: 10.1097/RCT.0000000000001028. PMID: 32558766
Expression of the epidermal growth factor system in endometrial cancer after adjuvant tamoxifen treatment for breast cancer.
Androutsopoulos G, Adonakis G, Gkermpesi M, Gkogkos P, Ravazoula P, Kourounis G
Eur J Gynaecol Oncol 2006;27(5):490-4. PMID: 17139985
Clinicopathologic study of 56 patients with endometrial cancer during or after adjuvant tamoxifen use for their breast cancers.
Hachisuga T, Saito T, Kigawa J, Ohwada M, Yamazawa K, Yasue A, Iwasaka T, Sugiyama T, Kita T, Nagai N
Gynecol Oncol 2004 Oct;95(1):139-44. doi: 10.1016/j.ygyno.2004.07.019. PMID: 15385123
Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology.
Kennedy MM, Baigrie CF, Manek S
Int J Gynecol Pathol 1999 Apr;18(2):130-7. PMID: 10202670

Therapy

Assessment of Tamoxifen-Related Endometrial Changes in Premenopausal Female Patients With Diffusion-Weighted Magnetic Resonance Imaging.
Abdel Razek AAK, Elkalla HMHR, Refky B, Elsergany A, Sakrana AA, Saleh G, Gadelhak BN
J Comput Assist Tomogr 2020 Jul/Aug;44(4):485-489. doi: 10.1097/RCT.0000000000001028. PMID: 32558766
Concurrent tamoxifen-related Müllerian adenofibromas in uterus and ovary.
Shi H, Chen X, Lv B, Zhang X
Int J Clin Exp Pathol 2015;8(11):15381-5. Epub 2015 Nov 1 PMID: 26823898Free PMC Article
Expression of the epidermal growth factor system in endometrial cancer after adjuvant tamoxifen treatment for breast cancer.
Androutsopoulos G, Adonakis G, Gkermpesi M, Gkogkos P, Ravazoula P, Kourounis G
Eur J Gynaecol Oncol 2006;27(5):490-4. PMID: 17139985
Combined modality treatment of locally advanced breast carcinoma in elderly patients or patients with severe comorbid conditions using tamoxifen as the primary therapy.
Hoff PM, Valero V, Buzdar AU, Singletary SE, Theriault RL, Booser D, Asmar L, Frye D, McNeese MD, Hortobagyi GN
Cancer 2000 May 1;88(9):2054-60. doi: 10.1002/(sici)1097-0142(20000501)88:9<2054::aid-cncr11>3.0.co;2-j. PMID: 10813717
Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology.
Kennedy MM, Baigrie CF, Manek S
Int J Gynecol Pathol 1999 Apr;18(2):130-7. PMID: 10202670

Prognosis

Expression of the epidermal growth factor system in endometrial cancer after adjuvant tamoxifen treatment for breast cancer.
Androutsopoulos G, Adonakis G, Gkermpesi M, Gkogkos P, Ravazoula P, Kourounis G
Eur J Gynaecol Oncol 2006;27(5):490-4. PMID: 17139985
Clinicopathologic study of 56 patients with endometrial cancer during or after adjuvant tamoxifen use for their breast cancers.
Hachisuga T, Saito T, Kigawa J, Ohwada M, Yamazawa K, Yasue A, Iwasaka T, Sugiyama T, Kita T, Nagai N
Gynecol Oncol 2004 Oct;95(1):139-44. doi: 10.1016/j.ygyno.2004.07.019. PMID: 15385123
Combined modality treatment of locally advanced breast carcinoma in elderly patients or patients with severe comorbid conditions using tamoxifen as the primary therapy.
Hoff PM, Valero V, Buzdar AU, Singletary SE, Theriault RL, Booser D, Asmar L, Frye D, McNeese MD, Hortobagyi GN
Cancer 2000 May 1;88(9):2054-60. doi: 10.1002/(sici)1097-0142(20000501)88:9<2054::aid-cncr11>3.0.co;2-j. PMID: 10813717

Clinical prediction guides

Assessment of Tamoxifen-Related Endometrial Changes in Premenopausal Female Patients With Diffusion-Weighted Magnetic Resonance Imaging.
Abdel Razek AAK, Elkalla HMHR, Refky B, Elsergany A, Sakrana AA, Saleh G, Gadelhak BN
J Comput Assist Tomogr 2020 Jul/Aug;44(4):485-489. doi: 10.1097/RCT.0000000000001028. PMID: 32558766
Combined modality treatment of locally advanced breast carcinoma in elderly patients or patients with severe comorbid conditions using tamoxifen as the primary therapy.
Hoff PM, Valero V, Buzdar AU, Singletary SE, Theriault RL, Booser D, Asmar L, Frye D, McNeese MD, Hortobagyi GN
Cancer 2000 May 1;88(9):2054-60. doi: 10.1002/(sici)1097-0142(20000501)88:9<2054::aid-cncr11>3.0.co;2-j. PMID: 10813717

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