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Retroperitoneal Gastrointestinal Stromal Tumor

MedGen UID:
271680
•Concept ID:
C1514920
•
Neoplastic Process
Synonyms: Retroperitoneal EGIST; Retroperitoneal Extragastrointestinal Stromal Tumor

Definition

A gastrointestinal stromal tumor that arises from the retroperitoneum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetroperitoneal Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Evidence for the Current Management of Soft-tissue Sarcoma and Gastrointestinal Stromal Tumors and Emerging Directions.
Dossa F, Gladdy RA
Surg Oncol Clin N Am 2023 Jan;32(1):169-184. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.07.010. PMID: 36410916
Brazilian consensus on the diagnosis and treatment of extremities soft tissue sarcomas.
Spencer RMSSB, de Camargo VP, Silva MLG, Pinto FFE, Costa FD, Cequeira WS, Munhoz RR, Mello CA, Schmerling RA, Filho WJD, Coelho TM, Ambrosio AVA, Leite ETT, Hanna SA, Nakagawa SA, Baptista AM, Pinheiro RN, de Oliveira JL, de Araújo MS, de Araujo RLC, Laporte GA, de Almeida Quadros C, de Oliveira AF, Lopes A
J Surg Oncol 2020 Apr;121(5):743-758. Epub 2020 Jan 22 doi: 10.1002/jso.25847. PMID: 31970785
The consensus statement on the locoregional treatment of abdominal sarcomatosis.
Rossi CR, Casali P, Kusamura S, Baratti D, Deraco M
J Surg Oncol 2008 Sep 15;98(4):291-4. doi: 10.1002/jso.21067. PMID: 18726899

Recent clinical studies

Etiology

Evidence for the Current Management of Soft-tissue Sarcoma and Gastrointestinal Stromal Tumors and Emerging Directions.
Dossa F, Gladdy RA
Surg Oncol Clin N Am 2023 Jan;32(1):169-184. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.07.010. PMID: 36410916
Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
Levy AD, Manning MA, Miettinen MM
Radiographics 2017 May-Jun;37(3):797-812. doi: 10.1148/rg.2017160201. PMID: 28493803Free PMC Article
Needle tract seeding after percutaneous biopsy of sarcoma: Risk/benefit considerations.
Berger-Richardson D, Swallow CJ
Cancer 2017 Feb 15;123(4):560-567. Epub 2016 Nov 2 doi: 10.1002/cncr.30370. PMID: 27859013
Survival After Resection of Gastrointestinal Stromal Tumor and Sarcoma Liver Metastases in 146 Patients.
Brudvik KW, Patel SH, Roland CL, Conrad C, Torres KE, Hunt KK, Cormier JN, Feig BW, Aloia TA, Vauthey JN
J Gastrointest Surg 2015 Aug;19(8):1476-83. Epub 2015 May 22 doi: 10.1007/s11605-015-2845-9. PMID: 26001368Free PMC Article
Gastrointestinal and retroperitoneal manifestations of type 1 neurofibromatosis.
Basile U, Cavallaro G, Polistena A, Giustini S, Orlando G, Cotesta D, Petramala L, Letizia C, Calvieri S, De Toma G
J Gastrointest Surg 2010 Jan;14(1):186-94. doi: 10.1007/s11605-009-0940-5. PMID: 19495890

Diagnosis

Ileal gastrointestinal stromal tumor presenting as retroperitoneal mass.
Ergenç M, Uprak TK
J Cancer Res Ther 2022 Dec;18(Supplement):S460-S462. doi: 10.4103/jcrt.jcrt_1089_21. PMID: 36511004
Brazilian consensus on the diagnosis and treatment of extremities soft tissue sarcomas.
Spencer RMSSB, de Camargo VP, Silva MLG, Pinto FFE, Costa FD, Cequeira WS, Munhoz RR, Mello CA, Schmerling RA, Filho WJD, Coelho TM, Ambrosio AVA, Leite ETT, Hanna SA, Nakagawa SA, Baptista AM, Pinheiro RN, de Oliveira JL, de Araújo MS, de Araujo RLC, Laporte GA, de Almeida Quadros C, de Oliveira AF, Lopes A
J Surg Oncol 2020 Apr;121(5):743-758. Epub 2020 Jan 22 doi: 10.1002/jso.25847. PMID: 31970785
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article
Gastrointestinal and retroperitoneal manifestations of type 1 neurofibromatosis.
Basile U, Cavallaro G, Polistena A, Giustini S, Orlando G, Cotesta D, Petramala L, Letizia C, Calvieri S, De Toma G
J Gastrointest Surg 2010 Jan;14(1):186-94. doi: 10.1007/s11605-009-0940-5. PMID: 19495890
Retroperitoneal and intra-abdominal sarcoma.
Liles JS, Tzeng CW, Short JJ, Kulesza P, Heslin MJ
Curr Probl Surg 2009 Jun;46(6):445-503. doi: 10.1067/j.cpsurg.2009.01.004. PMID: 19414097

Therapy

Relevant Trials Update in Sarcomas and Gastrointestinal Stromal Tumors: What Surgeons Should Know.
Callegaro D, Roland CL, Raut CP
Surg Oncol Clin N Am 2022 Jul;31(3):341-360. doi: 10.1016/j.soc.2022.03.002. PMID: 35715138
Preoperative adjuvant therapy for locally advanced and recurrent/metastatic gastrointestinal stromal tumors: a retrospective study.
Qi J, Liu HL, Ren F, Liu S, Shi W, Liu WH, Cai GQ, Liao GQ
World J Surg Oncol 2020 Apr 7;18(1):70. doi: 10.1186/s12957-020-01840-9. PMID: 32264886Free PMC Article
Needle tract seeding after percutaneous biopsy of sarcoma: Risk/benefit considerations.
Berger-Richardson D, Swallow CJ
Cancer 2017 Feb 15;123(4):560-567. Epub 2016 Nov 2 doi: 10.1002/cncr.30370. PMID: 27859013
Survival After Resection of Gastrointestinal Stromal Tumor and Sarcoma Liver Metastases in 146 Patients.
Brudvik KW, Patel SH, Roland CL, Conrad C, Torres KE, Hunt KK, Cormier JN, Feig BW, Aloia TA, Vauthey JN
J Gastrointest Surg 2015 Aug;19(8):1476-83. Epub 2015 May 22 doi: 10.1007/s11605-015-2845-9. PMID: 26001368Free PMC Article
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article

Prognosis

Ileal gastrointestinal stromal tumor presenting as retroperitoneal mass.
Ergenç M, Uprak TK
J Cancer Res Ther 2022 Dec;18(Supplement):S460-S462. doi: 10.4103/jcrt.jcrt_1089_21. PMID: 36511004
Outcomes in the management of adult soft tissue sarcomas.
Kneisl JS, Coleman MM, Raut CP
J Surg Oncol 2014 Oct;110(5):527-38. Epub 2014 Jun 25 doi: 10.1002/jso.23685. PMID: 24965077
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article
Retroperitoneal and intra-abdominal sarcoma.
Liles JS, Tzeng CW, Short JJ, Kulesza P, Heslin MJ
Curr Probl Surg 2009 Jun;46(6):445-503. doi: 10.1067/j.cpsurg.2009.01.004. PMID: 19414097
Gene expression profiling in sarcomas.
Tschoep K, Kohlmann A, Schlemmer M, Haferlach T, Issels RD
Crit Rev Oncol Hematol 2007 Aug;63(2):111-24. Epub 2007 Jun 6 doi: 10.1016/j.critrevonc.2007.04.001. PMID: 17555981

Clinical prediction guides

Clinicopathologic and Surgical Characteristics Study of 151 Cases of GIST.
Şentürk M, Yıldırım MA, Çakır M, Kişi Ö
J Gastrointest Cancer 2021 Jun;52(2):542-546. doi: 10.1007/s12029-020-00414-y. PMID: 32445057
Discovered on gastrointestinal stromal tumor 1, a keystone in the diagnosis of extraintestinal gastrointestinal stromal tumors.
Sahu KK, Tapadia R, Kini JR, Pai RR, Kini H, Nirupama M, Pooja KS
J Cancer Res Ther 2019 Jan-Mar;15(1):138-141. doi: 10.4103/jcrt.JCRT_28_17. PMID: 30880769
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article
Gene expression profiling in sarcomas.
Tschoep K, Kohlmann A, Schlemmer M, Haferlach T, Issels RD
Crit Rev Oncol Hematol 2007 Aug;63(2):111-24. Epub 2007 Jun 6 doi: 10.1016/j.critrevonc.2007.04.001. PMID: 17555981
Gastrointestinal stromal tumors and leiomyosarcoma of the abdomen and retroperitoneum: a clinical comparison.
Clary BM, DeMatteo RP, Lewis JJ, Leung D, Brennan MF
Ann Surg Oncol 2001 May;8(4):290-9. doi: 10.1007/s10434-001-0290-3. PMID: 11352301

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