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c-erbB2 Messenger RNA Overexpression

MedGen UID:
271830
•Concept ID:
C1515559
•
Cell or Molecular Dysfunction
Synonyms: ERBB2 Messenger RNA Overexpression; ERBB2 mRNA Overexpression

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVc-erbB2 Messenger RNA Overexpression

Recent clinical studies

Etiology

90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells.
Fusco O, Querzoli P, Nenci I, Natoli C, Brakebush C, Ullrich A, Iacobelli S
Int J Cancer 1998 Feb 20;79(1):23-6. doi: 10.1002/(sici)1097-0215(19980220)79:1<23::aid-ijc5>3.0.co;2-y. PMID: 9495353
C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification and correlation with prognosis.
Parkes HC, Lillycrop K, Howell A, Craig RK
Br J Cancer 1990 Jan;61(1):39-45. doi: 10.1038/bjc.1990.9. PMID: 2153396Free PMC Article

Diagnosis

T-DM1, a novel antibody-drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivo.
English DP, Bellone S, Schwab CL, Bortolomai I, Bonazzoli E, Cocco E, Buza N, Hui P, Lopez S, Ratner E, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Santin AD
Cancer Med 2014 Oct;3(5):1256-65. Epub 2014 Jun 2 doi: 10.1002/cam4.274. PMID: 24890382Free PMC Article
Diagnostic relevance of overexpressed NOK mRNA in breast cancer.
Moriai R, Kobayashi D, Amachika T, Tsuji N, Watanabe N
Anticancer Res 2006 Nov-Dec;26(6C):4969-73. PMID: 17214372
c-erbB2 gene amplification and protein expression in ovarian epithelial tumors: evaluation of their respective prognostic significance by multivariate analysis.
Fajac A, Benard J, Lhomme C, Rey A, Duvillard P, Rochard F, Bernaudin JF, Riou G
Int J Cancer 1995 Apr 21;64(2):146-51. doi: 10.1002/ijc.2910640213. PMID: 7615357

Prognosis

Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer.
Järvinen TA, Kononen J, Pelto-Huikko M, Isola J
Am J Pathol 1996 Jun;148(6):2073-82. PMID: 8669491Free PMC Article
c-erbB2 gene amplification and protein expression in ovarian epithelial tumors: evaluation of their respective prognostic significance by multivariate analysis.
Fajac A, Benard J, Lhomme C, Rey A, Duvillard P, Rochard F, Bernaudin JF, Riou G
Int J Cancer 1995 Apr 21;64(2):146-51. doi: 10.1002/ijc.2910640213. PMID: 7615357
The type I growth factor receptors in human breast cancer.
Rajkumar T, Gullick WJ
Breast Cancer Res Treat 1994 Jan;29(1):3-9. doi: 10.1007/BF00666177. PMID: 7912566
Strong association between c-myb and oestrogen-receptor expression in human breast cancer.
Guérin M, Sheng ZM, Andrieu N, Riou G
Oncogene 1990 Jan;5(1):131-5. PMID: 2181374
C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification and correlation with prognosis.
Parkes HC, Lillycrop K, Howell A, Craig RK
Br J Cancer 1990 Jan;61(1):39-45. doi: 10.1038/bjc.1990.9. PMID: 2153396Free PMC Article

Clinical prediction guides

Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer.
Järvinen TA, Kononen J, Pelto-Huikko M, Isola J
Am J Pathol 1996 Jun;148(6):2073-82. PMID: 8669491Free PMC Article
c-erbB2 gene amplification and protein expression in ovarian epithelial tumors: evaluation of their respective prognostic significance by multivariate analysis.
Fajac A, Benard J, Lhomme C, Rey A, Duvillard P, Rochard F, Bernaudin JF, Riou G
Int J Cancer 1995 Apr 21;64(2):146-51. doi: 10.1002/ijc.2910640213. PMID: 7615357
The type I growth factor receptors in human breast cancer.
Rajkumar T, Gullick WJ
Breast Cancer Res Treat 1994 Jan;29(1):3-9. doi: 10.1007/BF00666177. PMID: 7912566
Expression of c-erbB2, TGF-beta 1 and pS2 genes in primary human breast cancers.
Delvenne CG, Winkler-Gol RA, Piccart MJ, Hustin J, Michaux D, Leclercq G, Nogaret JM, Autier P
Eur J Cancer 1992;28(2-3):700-5. doi: 10.1016/s0959-8049(05)80130-3. PMID: 1350458
C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification and correlation with prognosis.
Parkes HC, Lillycrop K, Howell A, Craig RK
Br J Cancer 1990 Jan;61(1):39-45. doi: 10.1038/bjc.1990.9. PMID: 2153396Free PMC Article

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