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Anaplastic Lymphoma

MedGen UID:
272106
Concept ID:
C1321546
Neoplastic Process
Synonym: Anaplastic Large B-Cell Lymphoma

Definition

A diffuse large B-cell lymphoma variant characterized by the presence of large round, oval, or polygonal cells with bizarre pleomorphic nuclei resembling Hodgkin or Reed-Sternberg cells. It is unrelated to anaplastic large cell lymphoma which is a T-cell non-Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Yin X, Li Y, Wang H, Jia T, Wang E, Luo Y, Wei Y, Qin Z, Ma X
Semin Cancer Biol 2022 Nov;86(Pt 2):595-606. Epub 2022 Mar 8 doi: 10.1016/j.semcancer.2022.03.006. PMID: 35276343
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216

Recent clinical studies

Etiology

Lee MS, Sanoff HK
BMJ 2020 Dec 7;371:m4050. doi: 10.1136/bmj.m4050. PMID: 33288500
Camidge DR, Dziadziuszko R, Peters S, Mok T, Noe J, Nowicka M, Gadgeel SM, Cheema P, Pavlakis N, de Marinis F, Cho BC, Zhang L, Moro-Sibilot D, Liu T, Bordogna W, Balas B, Müller B, Shaw AT
J Thorac Oncol 2019 Jul;14(7):1233-1243. Epub 2019 Mar 20 doi: 10.1016/j.jtho.2019.03.007. PMID: 30902613
Shaw AT, Solomon BJ, Besse B, Bauer TM, Lin CC, Soo RA, Riely GJ, Ou SI, Clancy JS, Li S, Abbattista A, Thurm H, Satouchi M, Camidge DR, Kao S, Chiari R, Gadgeel SM, Felip E, Martini JF
J Clin Oncol 2019 Jun 1;37(16):1370-1379. Epub 2019 Mar 20 doi: 10.1200/JCO.18.02236. PMID: 30892989Free PMC Article
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
Gridelli C, Rossi A, Carbone DP, Guarize J, Karachaliou N, Mok T, Petrella F, Spaggiari L, Rosell R
Nat Rev Dis Primers 2015 May 21;1:15009. doi: 10.1038/nrdp.2015.9. PMID: 27188576

Diagnosis

Goto Y, Shukuya T, Murata A, Kikkawa H, Emir B, Wiltshire R, Miura S
Cancer Sci 2023 Jun;114(6):2560-2568. Epub 2023 Apr 2 doi: 10.1111/cas.15777. PMID: 36866958Free PMC Article
Remon J, Pignataro D, Novello S, Passiglia F
Cancer Treat Rev 2021 Apr;95:102178. Epub 2021 Mar 10 doi: 10.1016/j.ctrv.2021.102178. PMID: 33743408
Sánchez Rubio N, Lannegrand Menéndez B, Duque Muñoz M, Montes Fernández M, Ciudad Fernández MJ
Radiologia (Engl Ed) 2020 Jul-Aug;62(4):266-279. Epub 2020 Apr 6 doi: 10.1016/j.rx.2020.01.008. PMID: 32273126
Golding B, Luu A, Jones R, Viloria-Petit AM
Mol Cancer 2018 Feb 19;17(1):52. doi: 10.1186/s12943-018-0810-4. PMID: 29455675Free PMC Article
Minoo P, Wang HY
Int J Clin Exp Pathol 2012;5(5):397-410. Epub 2012 May 23 PMID: 22808292Free PMC Article

Therapy

Camidge DR, Kim HR, Ahn MJ, Yang JCH, Han JY, Hochmair MJ, Lee KH, Delmonte A, Garcia Campelo MR, Kim DW, Griesinger F, Felip E, Califano R, Spira AI, Gettinger SN, Tiseo M, Lin HM, Liu Y, Vranceanu F, Niu H, Zhang P, Popat S
J Thorac Oncol 2021 Dec;16(12):2091-2108. Epub 2021 Sep 16 doi: 10.1016/j.jtho.2021.07.035. PMID: 34537440
Shaw AT, Bauer TM, de Marinis F, Felip E, Goto Y, Liu G, Mazieres J, Kim DW, Mok T, Polli A, Thurm H, Calella AM, Peltz G, Solomon BJ; CROWN Trial Investigators
N Engl J Med 2020 Nov 19;383(21):2018-2029. doi: 10.1056/NEJMoa2027187. PMID: 33207094
Mok TSK, Wu YL, Kudaba I, Kowalski DM, Cho BC, Turna HZ, Castro G Jr, Srimuninnimit V, Laktionov KK, Bondarenko I, Kubota K, Lubiniecki GM, Zhang J, Kush D, Lopes G; KEYNOTE-042 Investigators
Lancet 2019 May 4;393(10183):1819-1830. Epub 2019 Apr 4 doi: 10.1016/S0140-6736(18)32409-7. PMID: 30955977
Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Pérol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T; ALEX Trial Investigators
N Engl J Med 2017 Aug 31;377(9):829-838. Epub 2017 Jun 6 doi: 10.1056/NEJMoa1704795. PMID: 28586279
Reck M, Rodríguez-Abreu D, Robinson AG, Hui R, Csőszi T, Fülöp A, Gottfried M, Peled N, Tafreshi A, Cuffe S, O'Brien M, Rao S, Hotta K, Leiby MA, Lubiniecki GM, Shentu Y, Rangwala R, Brahmer JR; KEYNOTE-024 Investigators
N Engl J Med 2016 Nov 10;375(19):1823-1833. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1606774. PMID: 27718847

Prognosis

Camidge DR, Kim HR, Ahn MJ, Yang JCH, Han JY, Hochmair MJ, Lee KH, Delmonte A, García Campelo MR, Kim DW, Griesinger F, Felip E, Califano R, Spira A, Gettinger SN, Tiseo M, Lin HM, Gupta N, Hanley MJ, Ni Q, Zhang P, Popat S
J Clin Oncol 2020 Nov 1;38(31):3592-3603. Epub 2020 Aug 11 doi: 10.1200/JCO.20.00505. PMID: 32780660Free PMC Article
Camidge DR, Dziadziuszko R, Peters S, Mok T, Noe J, Nowicka M, Gadgeel SM, Cheema P, Pavlakis N, de Marinis F, Cho BC, Zhang L, Moro-Sibilot D, Liu T, Bordogna W, Balas B, Müller B, Shaw AT
J Thorac Oncol 2019 Jul;14(7):1233-1243. Epub 2019 Mar 20 doi: 10.1016/j.jtho.2019.03.007. PMID: 30902613
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Novello S, Mazières J, Oh IJ, de Castro J, Migliorino MR, Helland Å, Dziadziuszko R, Griesinger F, Kotb A, Zeaiter A, Cardona A, Balas B, Johannsdottir HK, Das-Gupta A, Wolf J
Ann Oncol 2018 Jun 1;29(6):1409-1416. doi: 10.1093/annonc/mdy121. PMID: 29668860Free PMC Article
Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Pérol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T; ALEX Trial Investigators
N Engl J Med 2017 Aug 31;377(9):829-838. Epub 2017 Jun 6 doi: 10.1056/NEJMoa1704795. PMID: 28586279

Clinical prediction guides

Camidge DR, Kim HR, Ahn MJ, Yang JCH, Han JY, Hochmair MJ, Lee KH, Delmonte A, García Campelo MR, Kim DW, Griesinger F, Felip E, Califano R, Spira A, Gettinger SN, Tiseo M, Lin HM, Gupta N, Hanley MJ, Ni Q, Zhang P, Popat S
J Clin Oncol 2020 Nov 1;38(31):3592-3603. Epub 2020 Aug 11 doi: 10.1200/JCO.20.00505. PMID: 32780660Free PMC Article
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
Nakano K, Takahashi S
Int J Mol Sci 2018 Nov 28;19(12) doi: 10.3390/ijms19123784. PMID: 30487384Free PMC Article
Chapman AM, Sun KY, Ruestow P, Cowan DM, Madl AK
Lung Cancer 2016 Dec;102:122-134. Epub 2016 Oct 25 doi: 10.1016/j.lungcan.2016.10.010. PMID: 27987580
Gainor JF, Dardaei L, Yoda S, Friboulet L, Leshchiner I, Katayama R, Dagogo-Jack I, Gadgeel S, Schultz K, Singh M, Chin E, Parks M, Lee D, DiCecca RH, Lockerman E, Huynh T, Logan J, Ritterhouse LL, Le LP, Muniappan A, Digumarthy S, Channick C, Keyes C, Getz G, Dias-Santagata D, Heist RS, Lennerz J, Sequist LV, Benes CH, Iafrate AJ, Mino-Kenudson M, Engelman JA, Shaw AT
Cancer Discov 2016 Oct;6(10):1118-1133. Epub 2016 Jul 18 doi: 10.1158/2159-8290.CD-16-0596. PMID: 27432227Free PMC Article

Recent systematic reviews

Luo Y, Zhang Z, Guo X, Tang X, Li S, Gong G, Gao S, Zhang Y, Lin S
Lung Cancer 2023 Oct;184:107319. Epub 2023 Aug 7 doi: 10.1016/j.lungcan.2023.107319. PMID: 37597303
Peng Y, Zhao Q, Liao Z, Ma Y, Ma D
Cancer 2023 Apr 15;129(8):1261-1275. Epub 2023 Feb 7 doi: 10.1002/cncr.34664. PMID: 36748799
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Wang L, Sheng Z, Zhang J, Song J, Teng L, Liu L, Li Q, Wang B, Li B
J Chemother 2022 Apr;34(2):87-96. Epub 2021 Jun 17 doi: 10.1080/1120009X.2021.1937782. PMID: 34139965
Kim B, Roth C, Chung KC, Young VL, van Busum K, Schnyer C, Mattke S
Plast Reconstr Surg 2011 Jun;127(6):2141-2150. doi: 10.1097/PRS.0b013e3182172418. PMID: 21358562

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