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AIDS-Related Malignant Anal Neoplasm

MedGen UID:
272258
•Concept ID:
C1332049
•
Neoplastic Process
Synonyms: AIDS-Related Malignant Anal Tumor; AIDS-Related Malignant Neoplasm of Anus; AIDS-Related Malignant Neoplasm of the Anus; AIDS-Related Malignant Tumor of Anus; AIDS-Related Malignant Tumor of the Anus

Definition

A malignant neoplasm arising from the anus and occurring in HIV-positive patients. Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma. Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population. [from NCI]

Professional guidelines

PubMed

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399

Recent clinical studies

Etiology

Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Biology of HPV in HIV infection.
Palefsky J
Adv Dent Res 2006 Apr 1;19(1):99-105. doi: 10.1177/154407370601900120. PMID: 16672559
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
The epidemiology of AIDS--related neoplasms.
Biggar RJ, Rabkin CS
Hematol Oncol Clin North Am 1996 Oct;10(5):997-1010. doi: 10.1016/s0889-8588(05)70380-4. PMID: 8880192
Epidemiology of AIDS-related malignancies.
Rabkin CS
Curr Opin Oncol 1994 Sep;6(5):492-6. doi: 10.1097/00001622-199409000-00008. PMID: 7827152

Diagnosis

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399

Therapy

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Biology of HPV in HIV infection.
Palefsky J
Adv Dent Res 2006 Apr 1;19(1):99-105. doi: 10.1177/154407370601900120. PMID: 16672559
Human papillomavirus-related cervical and anal disease in HIV-infected individuals in the era of highly active antiretroviral therapy.
Piketty C, Kazatchkine MD
Curr HIV/AIDS Rep 2005 Aug;2(3):140-5. doi: 10.1007/s11904-005-0007-5. PMID: 16091261
AIDS-related tumors: integrating antiviral and anticancer therapy.
Tirelli U, Bernardi D, Spina M, Vaccher E
Crit Rev Oncol Hematol 2002 Mar;41(3):299-315. doi: 10.1016/s1040-8428(01)00165-2. PMID: 11880206

Prognosis

Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
AIDS malignancies in the era of highly active antiretroviral therapy.
Gates AE, Kaplan LD
Oncology (Williston Park) 2002 Apr;16(4):441-51, 456, 459. PMID: 12017534
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Acquired immunodeficiency syndrome-related Kaposi's sarcoma.
Wang CY, Schroeter AL, Su WP
Mayo Clin Proc 1995 Sep;70(9):869-79. PMID: 7643641

Clinical prediction guides

Non-AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era.
Zucchetto A, Virdone S, Taborelli M, Grande E, Camoni L, Pappagallo M, Regine V, Grippo F, Polesel J, Dal Maso L, Suligoi B, Frova L, Serraino D
J Acquir Immune Defic Syndr 2016 Oct 1;73(2):190-6. doi: 10.1097/QAI.0000000000001033. PMID: 27116048
The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA
Int J STD AIDS 2007 Feb;18(2):77-80. doi: 10.1258/095646207779949772. PMID: 17331275
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Acquired immunodeficiency syndrome-associated cancers in Sub-Saharan Africa.
Thomas JO
Semin Oncol 2001 Apr;28(2):198-206. doi: 10.1016/s0093-7754(01)90092-2. PMID: 11301383
Anal dysplasia in homosexual men: role of anoscopy and biopsy.
Surawicz CM, Kirby P, Critchlow C, Sayer J, Dunphy C, Kiviat N
Gastroenterology 1993 Sep;105(3):658-66. doi: 10.1016/0016-5085(93)90880-l. PMID: 8359638

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