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ALK-negative anaplastic large cell lymphoma

MedGen UID:
272266
Concept ID:
C1332078
Neoplastic Process
Synonyms: ALCL, ALK-; ALK negative anaplastic large cell lymphoma; ALK- ALCL; ALK- anaplastic large cell lymphoma; ALK-Negative Anaplastic Large Cell Lymphoma; Anaplastic large cell lymphoma, ALK (anaplastic lymphoma kinase) negative; Anaplastic large cell lymphoma, ALK negative; Anaplastic Large Cell Lymphoma, ALK-Negative; anaplastic large cell lymphoma, ALK-negative; Anaplastic lymphoma kinase negative anaplastic large cell lymphoma
SNOMED CT: Anaplastic large cell lymphoma, ALK negative (448212009); Anaplastic lymphoma kinase negative anaplastic large cell lymphoma (448212009); ALK negative anaplastic large cell lymphoma (1172729004); Anaplastic lymphoma kinase negative anaplastic large cell lymphoma (1172729004); Anaplastic large cell lymphoma, ALK (anaplastic lymphoma kinase) negative (1172729004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017603
Orphanet: ORPHA300903

Definition

A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVALK-negative anaplastic large cell lymphoma
Follow this link to review classifications for ALK-negative anaplastic large cell lymphoma in Orphanet.

Professional guidelines

PubMed

Chen H, Tao Y, Zhou Y, Liu P, Yang J, He X, Zhou S, Qin Y, Song Y, Gui L, Zhang C, Yang S, Shi Y
Asia Pac J Clin Oncol 2023 Oct;19(5):e202-e214. Epub 2022 Jul 12 doi: 10.1111/ajco.13831. PMID: 35821612
Wang X, Wu J, Zhang M
Hematology 2019 Dec;24(1):440-445. doi: 10.1080/16078454.2019.1613290. PMID: 31072226
Lunning MA
Oncology (Williston Park) 2015 Aug;29(8):545-50. PMID: 26281838

Recent clinical studies

Etiology

Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica 2023 Jun 1;108(6):1590-1603. doi: 10.3324/haematol.2022.281442. PMID: 36453105Free PMC Article
Yuan C, Duan H, Wang Y, Zhang J, Ou J, Wang W, Zhang M
Ann Palliat Med 2022 Apr;11(4):1554-1560. Epub 2021 Jul 1 doi: 10.21037/apm-21-557. PMID: 34263607
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Diagnosis

Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Greenland NY, Lu CM, Cook S, Peng Y
Diagn Cytopathol 2021 Dec;49(12):E458-E461. Epub 2021 Aug 18 doi: 10.1002/dc.24855. PMID: 34406711
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Therapy

Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica 2023 Jun 1;108(6):1590-1603. doi: 10.3324/haematol.2022.281442. PMID: 36453105Free PMC Article
Yuan C, Duan H, Wang Y, Zhang J, Ou J, Wang W, Zhang M
Ann Palliat Med 2022 Apr;11(4):1554-1560. Epub 2021 Jul 1 doi: 10.21037/apm-21-557. PMID: 34263607
Greenland NY, Lu CM, Cook S, Peng Y
Diagn Cytopathol 2021 Dec;49(12):E458-E461. Epub 2021 Aug 18 doi: 10.1002/dc.24855. PMID: 34406711
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264

Prognosis

Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Greenland NY, Lu CM, Cook S, Peng Y
Diagn Cytopathol 2021 Dec;49(12):E458-E461. Epub 2021 Aug 18 doi: 10.1002/dc.24855. PMID: 34406711
Parkhi M, Bal A, Das A, Kashyap D, Bhardwaj S, Prakash G, Malhotra P
Appl Immunohistochem Mol Morphol 2021 Oct 1;29(9):648-656. doi: 10.1097/PAI.0000000000000936. PMID: 33901030
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Clinical prediction guides

Fratoni S, Trawinska MM, Capalbo A, Bernardini L, Fabbretti M, Martini M, Niscola P, Zhao XF
Virchows Arch 2022 Dec;481(6):975-979. Epub 2022 Jul 26 doi: 10.1007/s00428-022-03386-5. PMID: 35879438
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, Sidhu JS, Hsi ED, Karikehalli S, Jiang L, Vasmatzis G, Gibson SE, Ondrejka S, Nicolae A, Grogg KL, Allmer C, Ristow KM, Wilson WH, Macon WR, Law ME, Cerhan JR, Habermann TM, Ansell SM, Dogan A, Maurer MJ, Feldman AL
Blood 2014 Aug 28;124(9):1473-80. Epub 2014 Jun 3 doi: 10.1182/blood-2014-04-571091. PMID: 24894770Free PMC Article
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

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