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ALK-negative anaplastic large cell lymphoma

MedGen UID:
272266
Concept ID:
C1332078
Neoplastic Process
Synonyms: ALCL, ALK-; ALK negative anaplastic large cell lymphoma; ALK- ALCL; ALK- anaplastic large cell lymphoma; ALK-Negative Anaplastic Large Cell Lymphoma; Anaplastic large cell lymphoma, ALK (anaplastic lymphoma kinase) negative; Anaplastic large cell lymphoma, ALK negative; Anaplastic Large Cell Lymphoma, ALK-Negative; anaplastic large cell lymphoma, ALK-negative; Anaplastic lymphoma kinase negative anaplastic large cell lymphoma
SNOMED CT: Anaplastic large cell lymphoma, ALK negative (448212009); Anaplastic lymphoma kinase negative anaplastic large cell lymphoma (448212009); ALK negative anaplastic large cell lymphoma (1172729004); Anaplastic lymphoma kinase negative anaplastic large cell lymphoma (1172729004); Anaplastic large cell lymphoma, ALK (anaplastic lymphoma kinase) negative (1172729004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017603
Orphanet: ORPHA300903

Definition

A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK). [from ORDO]

Professional guidelines

PubMed

Chen H, Tao Y, Zhou Y, Liu P, Yang J, He X, Zhou S, Qin Y, Song Y, Gui L, Zhang C, Yang S, Shi Y
Asia Pac J Clin Oncol 2023 Oct;19(5):e202-e214. Epub 2022 Jul 12 doi: 10.1111/ajco.13831. PMID: 35821612
Wang X, Wu J, Zhang M
Hematology 2019 Dec;24(1):440-445. doi: 10.1080/16078454.2019.1613290. PMID: 31072226
Lunning MA
Oncology (Williston Park) 2015 Aug;29(8):545-50. PMID: 26281838

Recent clinical studies

Etiology

Díaz de la Pinta FJ, Rodríguez Moreno M, Salgado RN, Carvajal García N, Santonja C, Pérez Buira S, Piris MA, Requena L, Manso R, Rodríguez-Pinilla SM
Hum Pathol 2023 Jul;137:71-78. Epub 2023 Apr 29 doi: 10.1016/j.humpath.2023.04.015. PMID: 37127078
Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica 2023 Jun 1;108(6):1590-1603. doi: 10.3324/haematol.2022.281442. PMID: 36453105Free PMC Article
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Luchtel RA, Zimmermann MT, Hu G, Dasari S, Jiang M, Oishi N, Jacobs HK, Zeng Y, Hundal T, Rech KL, Ketterling RP, Lee JH, Eckloff BW, Yan H, Gaonkar KS, Tian S, Ye Z, Kadin ME, Sidhu J, Jiang L, Voss J, Link BK, Syrbu SI, Facchetti F, Bennani NN, Slager SL, Ordog T, Kocher JP, Cerhan JR, Ansell SM, Feldman AL
Blood 2019 Jun 27;133(26):2776-2789. Epub 2019 May 17 doi: 10.1182/blood.2019000626. PMID: 31101622Free PMC Article
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Diagnosis

Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica 2023 Jun 1;108(6):1590-1603. doi: 10.3324/haematol.2022.281442. PMID: 36453105Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Lim MS, Bailey NG, King RL, Piris M
Am J Clin Pathol 2019 Aug 1;152(3):277-301. doi: 10.1093/ajcp/aqz078. PMID: 31278738
Lunning MA
Oncology (Williston Park) 2015 Aug;29(8):545-50. PMID: 26281838
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Therapy

Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica 2023 Jun 1;108(6):1590-1603. doi: 10.3324/haematol.2022.281442. PMID: 36453105Free PMC Article
Yuan C, Duan H, Wang Y, Zhang J, Ou J, Wang W, Zhang M
Ann Palliat Med 2022 Apr;11(4):1554-1560. Epub 2021 Jul 1 doi: 10.21037/apm-21-557. PMID: 34263607
Greenland NY, Lu CM, Cook S, Peng Y
Diagn Cytopathol 2021 Dec;49(12):E458-E461. Epub 2021 Aug 18 doi: 10.1002/dc.24855. PMID: 34406711
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264

Prognosis

Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica 2023 Jun 1;108(6):1590-1603. doi: 10.3324/haematol.2022.281442. PMID: 36453105Free PMC Article
Parkhi M, Bal A, Das A, Kashyap D, Bhardwaj S, Prakash G, Malhotra P
Appl Immunohistochem Mol Morphol 2021 Oct 1;29(9):648-656. doi: 10.1097/PAI.0000000000000936. PMID: 33901030
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Clinical prediction guides

Chen H, Tao Y, Zhou Y, Liu P, Yang J, He X, Zhou S, Qin Y, Song Y, Gui L, Zhang C, Yang S, Shi Y
Asia Pac J Clin Oncol 2023 Oct;19(5):e202-e214. Epub 2022 Jul 12 doi: 10.1111/ajco.13831. PMID: 35821612
Fratoni S, Trawinska MM, Capalbo A, Bernardini L, Fabbretti M, Martini M, Niscola P, Zhao XF
Virchows Arch 2022 Dec;481(6):975-979. Epub 2022 Jul 26 doi: 10.1007/s00428-022-03386-5. PMID: 35879438
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

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