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Ampulla of vater squamous cell carcinoma

MedGen UID:
272304
•Concept ID:
C1332251
•
Neoplastic Process
Synonyms: Ampulla of Vater Squamous Cell Carcinoma; ampulla of vater squamous cell carcinoma; ampulla of Vater squamous cell carcinoma; hepatopancreatic ampulla squamous cell carcinoma
 
Monarch Initiative: MONDO:0003490

Definition

A carcinoma with squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmpulla of vater squamous cell carcinoma

Recent clinical studies

Etiology

Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression.
Hoshimoto S, Hoshi S, Hishinuma S, Tomikawa M, Shirakawa H, Ozawa I, Wakamatsu S, Hoshi N, Hirabayashi K, Ogata Y
Scand J Gastroenterol 2017 Apr;52(4):425-430. Epub 2016 Dec 30 doi: 10.1080/00365521.2016.1273383. PMID: 28034323
Coexistent ampullary squamous cell carcinoma with adenocarcinoma of the pancreatic duct.
Pathak GS, Deshmukh SD, Yavalkar PA, Ashturkar AV
Saudi J Gastroenterol 2011 Nov-Dec;17(6):411-3. doi: 10.4103/1319-3767.87184. PMID: 22064341Free PMC Article
Treatment of tumors of the pancreatic head with suspected but unproved malignancy: is a nihilistic approach justified?
Böttger TC, Junginger T
World J Surg 1999 Feb;23(2):158-62; discussion 162-3. doi: 10.1007/pl00013168. PMID: 9880425
Biliary tract cancers in Cote-d'Or (France): incidence and natural history.
Renard P, Boutron MC, Faivre J, Milan C, Bedenne L, Hillon P, Klepping C
J Epidemiol Community Health 1987 Dec;41(4):344-8. doi: 10.1136/jech.41.4.344. PMID: 3455429Free PMC Article

Diagnosis

Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature.
Soni S, Elhence P, Varshney VK, Suman S
BMJ Case Rep 2021 Jan 7;14(1) doi: 10.1136/bcr-2020-236477. PMID: 33414110Free PMC Article
Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater.
Jang KT, Ahn S
Arch Pathol Lab Med 2016 May;140(5):429-36. doi: 10.5858/arpa.2015-0319-RA. PMID: 27128300
Adenosquamous carcinoma of the ampulla of Vater: a case report and literature review.
Hoshimoto S, Aiura K, Shito M, Kakefuda T, Sugiura H
World J Surg Oncol 2015 Sep 29;13:287. doi: 10.1186/s12957-015-0709-0. PMID: 26420726Free PMC Article
Primary squamous cell carcinoma of the ampulla of Vater.
Bolanaki H, Giatromanolaki A, Sivridis E, Karayiannakis AJ
JOP 2014 Jan 10;15(1):42-5. doi: 10.6092/1590-8577/1649. PMID: 24413783
High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.
Nassar H, Albores-Saavedra J, Klimstra DS
Am J Surg Pathol 2005 May;29(5):588-94. doi: 10.1097/01.pas.0000157974.05397.4f. PMID: 15832081

Therapy

Two-stage operation for synchronous triple primary cancer of the esophagus, stomach, and ampulla of Vater: report of a case.
Fukaya M, Abe T, Yokoyama Y, Itatsu K, Nagino M
Surg Today 2014 May;44(5):967-71. Epub 2013 Mar 17 doi: 10.1007/s00595-013-0549-x. PMID: 23504004
Treatment of tumors of the pancreatic head with suspected but unproved malignancy: is a nihilistic approach justified?
Böttger TC, Junginger T
World J Surg 1999 Feb;23(2):158-62; discussion 162-3. doi: 10.1007/pl00013168. PMID: 9880425
Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers.
Iwamoto KS, Mizuno T, Kurata A, Masuzawa M, Mori T, Seyama T
Hum Pathol 1998 Apr;29(4):412-6. doi: 10.1016/s0046-8177(98)90126-5. PMID: 9563795
Synchronous cancers of the esophagus and the ampulla of Vater after distal gastrectomy: successful removal of the esophagus, gastric remnant, duodenum, and pancreatic head.
Mafune K, Tanaka Y, Ma YY, Takubo K
J Surg Oncol 1995 Dec;60(4):277-81. doi: 10.1002/jso.2930600412. PMID: 8551739

Prognosis

Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature.
Soni S, Elhence P, Varshney VK, Suman S
BMJ Case Rep 2021 Jan 7;14(1) doi: 10.1136/bcr-2020-236477. PMID: 33414110Free PMC Article
Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression.
Hoshimoto S, Hoshi S, Hishinuma S, Tomikawa M, Shirakawa H, Ozawa I, Wakamatsu S, Hoshi N, Hirabayashi K, Ogata Y
Scand J Gastroenterol 2017 Apr;52(4):425-430. Epub 2016 Dec 30 doi: 10.1080/00365521.2016.1273383. PMID: 28034323
Adenosquamous carcinoma of the ampulla of Vater: a case report and literature review.
Hoshimoto S, Aiura K, Shito M, Kakefuda T, Sugiura H
World J Surg Oncol 2015 Sep 29;13:287. doi: 10.1186/s12957-015-0709-0. PMID: 26420726Free PMC Article
Primary squamous cell carcinoma of the ampulla of Vater.
Bolanaki H, Giatromanolaki A, Sivridis E, Karayiannakis AJ
JOP 2014 Jan 10;15(1):42-5. doi: 10.6092/1590-8577/1649. PMID: 24413783
High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.
Nassar H, Albores-Saavedra J, Klimstra DS
Am J Surg Pathol 2005 May;29(5):588-94. doi: 10.1097/01.pas.0000157974.05397.4f. PMID: 15832081

Clinical prediction guides

Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression.
Hoshimoto S, Hoshi S, Hishinuma S, Tomikawa M, Shirakawa H, Ozawa I, Wakamatsu S, Hoshi N, Hirabayashi K, Ogata Y
Scand J Gastroenterol 2017 Apr;52(4):425-430. Epub 2016 Dec 30 doi: 10.1080/00365521.2016.1273383. PMID: 28034323
Adenosquamous carcinoma of the ampulla of Vater: a case report and literature review.
Hoshimoto S, Aiura K, Shito M, Kakefuda T, Sugiura H
World J Surg Oncol 2015 Sep 29;13:287. doi: 10.1186/s12957-015-0709-0. PMID: 26420726Free PMC Article
Pathologic observations of the duodenum in 615 consecutive duodenal specimens in a single Japanese hospital: II. malignant lesions.
Terada T
Int J Clin Exp Pathol 2012;5(1):52-7. Epub 2012 Jan 1 PMID: 22295147Free PMC Article
Squamous cell carcinoma of the larynx metastasized to the ampulla of Vater. Report of a case.
Büyükçelik A, Ensari A, Sarioğlu M, Işikdogan A, Içli F
Tumori 2003 Mar-Apr;89(2):199-201. doi: 10.1177/030089160308900219. PMID: 12841672
In situ hybridization of Epstein-Barr virus in tumor cells and tumor-infiltrating lymphocytes of the gastrointestinal tract.
Cho YJ, Chang MS, Park SH, Kim HS, Kim WH
Hum Pathol 2001 Mar;32(3):297-301. doi: 10.1053/hupa.2001.22766. PMID: 11274639

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