U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anal Adenocarcinoma within Anorectal Fistula

MedGen UID:
272305
•Concept ID:
C1332258
•
Neoplastic Process
Synonyms: Adenocarcinoma of Anus within Anorectal Fistula; Adenocarcinoma of the Anus within Anorectal Fistula

Definition

An anal adenocarcinoma arising from the lining of an anorectal fistulous tract. The overlying anal mucosa does not show evidence of neoplastic changes. Some cases are associated with Crohn disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Adenocarcinoma within Anorectal Fistula

Recent clinical studies

Etiology

Anorectal Malignancies Presenting as a Perianal Abscess or Fistula.
Boaz E, Freund MR, Harbi A, Dagan A, Gilshtein H, Reissman P, Yellinek S
Am Surg 2023 Jun;89(6):2572-2576. Epub 2022 May 27 doi: 10.1177/00031348221101481. PMID: 35621130
Non-mucinous adenocarcinomas and squamous cell carcinomas of the anal region masquerading as abscess or fistula: a retrospective analysis and systematic review of literature.
Tekbaş A, Mothes H, Settmacher U, Schuele S
J Cancer Res Clin Oncol 2022 Jun;148(6):1509-1522. Epub 2021 Aug 2 doi: 10.1007/s00432-021-03747-8. PMID: 34338860Free PMC Article
Anal Neoplasia in Inflammatory Bowel Disease: Classification Proposal, Epidemiology, Carcinogenesis, and Risk Management Perspectives.
Wisniewski A, Fléjou JF, Siproudhis L, Abramowitz L, Svrcek M, Beaugerie L
J Crohns Colitis 2017 Aug 1;11(8):1011-1018. doi: 10.1093/ecco-jcc/jjx035. PMID: 28379306
Anal gland carcinoma.
Hobbs CM, Lowry MA, Owen D, Sobin LH
Cancer 2001 Oct 15;92(8):2045-9. doi: 10.1002/1097-0142(20011015)92:8<2045::aid-cncr1543>3.0.co;2-v. PMID: 11596018
Prognosis and recurrence patterns of anal adenocarcinoma.
Basik M, Rodriguez-Bigas MA, Penetrante R, Petrelli NJ
Am J Surg 1995 Feb;169(2):233-7. doi: 10.1016/S0002-9610(99)80143-3. PMID: 7840386

Diagnosis

Anorectal Malignancies Presenting as a Perianal Abscess or Fistula.
Boaz E, Freund MR, Harbi A, Dagan A, Gilshtein H, Reissman P, Yellinek S
Am Surg 2023 Jun;89(6):2572-2576. Epub 2022 May 27 doi: 10.1177/00031348221101481. PMID: 35621130
Anal Neoplasia in Inflammatory Bowel Disease: Classification Proposal, Epidemiology, Carcinogenesis, and Risk Management Perspectives.
Wisniewski A, Fléjou JF, Siproudhis L, Abramowitz L, Svrcek M, Beaugerie L
J Crohns Colitis 2017 Aug 1;11(8):1011-1018. doi: 10.1093/ecco-jcc/jjx035. PMID: 28379306
Adenocarcinoma of the anal canal: A report of two cases with review of literature.
Kulkarni MP, Momin YA, Pandav AB, Sulhyan KR
Indian J Pathol Microbiol 2016 Jul-Sep;59(3):404-6. doi: 10.4103/0377-4929.188139. PMID: 27510691
Rectosigmoid adenocarcinoma revealed by metastatic anal fistula. The visible part of the iceberg: a report of two cases with literature review.
Benjelloun el B, Aitalalim S, Chbani L, Mellouki I, Mazaz K, Aittaleb K
World J Surg Oncol 2012 Oct 3;10:209. doi: 10.1186/1477-7819-10-209. PMID: 23033985Free PMC Article
Carcinoma arising in anorectal fistulas of Crohn's disease.
Ky A, Sohn N, Weinstein MA, Korelitz BI
Dis Colon Rectum 1998 Aug;41(8):992-6. doi: 10.1007/BF02237388. PMID: 9715154

Therapy

Anorectal stricture in 102 patients with Crohn's disease: natural history in the era of biologics.
Brochard C, Siproudhis L, Wallenhorst T, Cuen D, d'Halluin PN, Garros A, Bretagne JF, Bouguen G
Aliment Pharmacol Ther 2014 Oct;40(7):796-803. Epub 2014 Aug 11 doi: 10.1111/apt.12894. PMID: 25109493
Adenocarcinoma associated with perianal fistulas in Crohn's disease.
Ogawa H, Haneda S, Shibata C, Miura K, Nagao M, Ohnuma S, Kohyama A, Unno M
Anticancer Res 2013 Feb;33(2):685-9. PMID: 23393368
Early results of intersphincteric resection for patients with very low rectal cancer: an active approach to avoid a permanent colostomy.
Saito N, Ono M, Sugito M, Ito M, Morihiro M, Kosugi C, Sato K, Kotaka M, Nomura S, Arai M, Kobatake T
Dis Colon Rectum 2004 Apr;47(4):459-66. Epub 2004 Feb 25 doi: 10.1007/s10350-003-0088-4. PMID: 14978613
Sphincter preservation after short-term preoperative radiotherapy for low rectal cancer--presentation of own data and a literature review.
Bujko K, Nowacki MP, Oledzki J, Sopyło R, Skoczylas J, Chwaliński M
Acta Oncol 2001;40(5):593-601. doi: 10.1080/028418601750444132. PMID: 11669331

Prognosis

Anal Neoplasia in Inflammatory Bowel Disease: Classification Proposal, Epidemiology, Carcinogenesis, and Risk Management Perspectives.
Wisniewski A, Fléjou JF, Siproudhis L, Abramowitz L, Svrcek M, Beaugerie L
J Crohns Colitis 2017 Aug 1;11(8):1011-1018. doi: 10.1093/ecco-jcc/jjx035. PMID: 28379306
Anorectal stricture in 102 patients with Crohn's disease: natural history in the era of biologics.
Brochard C, Siproudhis L, Wallenhorst T, Cuen D, d'Halluin PN, Garros A, Bretagne JF, Bouguen G
Aliment Pharmacol Ther 2014 Oct;40(7):796-803. Epub 2014 Aug 11 doi: 10.1111/apt.12894. PMID: 25109493
Carcinoma arising in anorectal fistulas of Crohn's disease.
Ky A, Sohn N, Weinstein MA, Korelitz BI
Dis Colon Rectum 1998 Aug;41(8):992-6. doi: 10.1007/BF02237388. PMID: 9715154
Prognosis and recurrence patterns of anal adenocarcinoma.
Basik M, Rodriguez-Bigas MA, Penetrante R, Petrelli NJ
Am J Surg 1995 Feb;169(2):233-7. doi: 10.1016/S0002-9610(99)80143-3. PMID: 7840386
Colonoscopy in patients with benign anorectal disease.
Longo WE, Dean PA, Virgo KS, Vernava AM 3rd
Dis Colon Rectum 1993 Apr;36(4):368-71. doi: 10.1007/BF02053941. PMID: 8458264

Clinical prediction guides

Adenocarcinoma in Crohn's disease: the pathologist's experience in a tertiary referral centre of inflammatory bowel disease.
Malvi D, Vasuri F, Mattioli B, Gruppioni E, Fiorentino M, Gionchetti P, Grigioni WF, Poggioli G, D'Errico-Grigioni A
Pathology 2014 Aug;46(5):439-43. doi: 10.1097/PAT.0000000000000123. PMID: 24977730
Early results of intersphincteric resection for patients with very low rectal cancer: an active approach to avoid a permanent colostomy.
Saito N, Ono M, Sugito M, Ito M, Morihiro M, Kosugi C, Sato K, Kotaka M, Nomura S, Arai M, Kobatake T
Dis Colon Rectum 2004 Apr;47(4):459-66. Epub 2004 Feb 25 doi: 10.1007/s10350-003-0088-4. PMID: 14978613
Anal gland carcinoma.
Hobbs CM, Lowry MA, Owen D, Sobin LH
Cancer 2001 Oct 15;92(8):2045-9. doi: 10.1002/1097-0142(20011015)92:8<2045::aid-cncr1543>3.0.co;2-v. PMID: 11596018
Intersphincteric resection with excision of internal anal sphincter for conservative treatment of very low rectal cancer.
Rullier E, Zerbib F, Laurent C, Bonnel C, Caudry M, Saric J, Parneix M
Dis Colon Rectum 1999 Sep;42(9):1168-75. doi: 10.1007/BF02238569. PMID: 10496557
Colonoscopy in patients with benign anorectal disease.
Longo WE, Dean PA, Virgo KS, Vernava AM 3rd
Dis Colon Rectum 1993 Apr;36(4):368-71. doi: 10.1007/BF02053941. PMID: 8458264

Recent systematic reviews

Non-mucinous adenocarcinomas and squamous cell carcinomas of the anal region masquerading as abscess or fistula: a retrospective analysis and systematic review of literature.
Tekbaş A, Mothes H, Settmacher U, Schuele S
J Cancer Res Clin Oncol 2022 Jun;148(6):1509-1522. Epub 2021 Aug 2 doi: 10.1007/s00432-021-03747-8. PMID: 34338860Free PMC Article

Supplemental Content

Table of contents

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...