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Atypical Adenomatous Lung Hyperplasia

MedGen UID:
272326
•Concept ID:
C1332345
•
Neoplastic Process
Synonyms: Atypical Adenomatous Hyperplasia of Lung; Atypical Adenomatous Hyperplasia of the Lung; Atypical Alveolar Hyperplasia; Bronchioloalveolar Cell Adenoma

Definition

A preinvasive lesion in the lung. It is characterized by the presence of a small, localized proliferation of mildly to moderately atypical type II pneumocytes and/or Clara cells lining alveolar walls and sometimes respiratory bronchioles. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Adenomatous Lung Hyperplasia

Professional guidelines

PubMed

Evaluation of Computer-Aided Nodule Assessment and Risk Yield (CANARY) in Korean patients for prediction of invasiveness of ground-glass opacity nodule.
Lee J, Bartholmai B, Peikert T, Chun J, Kim H, Kim JS, Park SY
PLoS One 2021;16(6):e0253204. Epub 2021 Jun 14 doi: 10.1371/journal.pone.0253204. PMID: 34125856Free PMC Article
Small peripheral glandular lesions detected by screening CT for lung cancer. A diagnostic dilemma for the pathologist.
Vazquez MF, Flieder DB
Radiol Clin North Am 2000 May;38(3):579-89. doi: 10.1016/s0033-8389(05)70186-x. PMID: 10855263
Pulmonary atypical adenomatous hyperplasia. A histologic lesion in search of usable criteria and clinical significance.
Ritter JH
Am J Clin Pathol 1999 May;111(5):587-9. doi: 10.1093/ajcp/111.5.587. PMID: 10230347

Recent clinical studies

Etiology

Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing.
Wang Z, Li Z, Zhou K, Wang C, Jiang L, Zhang L, Yang Y, Luo W, Qiao W, Wang G, Ni Y, Dai S, Guo T, Ji G, Xu M, Liu Y, Su Z, Che G, Li W
Nat Commun 2021 Nov 11;12(1):6500. doi: 10.1038/s41467-021-26770-2. PMID: 34764257Free PMC Article
Approach to the Subsolid Nodule.
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632
Interstitial lung abnormalities: prognostic stratification of subtle radiological findings.
Silva M, Milanese G, Sverzellati N
Curr Opin Pulm Med 2018 Sep;24(5):432-439. doi: 10.1097/MCP.0000000000000497. PMID: 29939864
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article
The association between atypical adenomatous hyperplasia and primary lung cancer.
Chapman AD, Kerr KM
Br J Cancer 2000 Sep;83(5):632-6. doi: 10.1054/bjoc.2000.1317. PMID: 10944604Free PMC Article

Diagnosis

Alveolar adenoma and coexisting atypical adenomatous hyperplasia: a case report and literature review.
Lu YW, Chang SL, Yeh YC, Hsieh YS
Pathologica 2022 Aug;114(4):326-331. doi: 10.32074/1591-951X-755. PMID: 36136901Free PMC Article
Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing.
Wang Z, Li Z, Zhou K, Wang C, Jiang L, Zhang L, Yang Y, Luo W, Qiao W, Wang G, Ni Y, Dai S, Guo T, Ji G, Xu M, Liu Y, Su Z, Che G, Li W
Nat Commun 2021 Nov 11;12(1):6500. doi: 10.1038/s41467-021-26770-2. PMID: 34764257Free PMC Article
Approach to the Subsolid Nodule.
Mase VJ Jr, Detterbeck FC
Clin Chest Med 2020 Mar;41(1):99-113. doi: 10.1016/j.ccm.2019.11.004. PMID: 32008632
Diagnostic Difficulties With Atrophy, Atypical Adenomatous Hyperplasia, and Atypical Small Acinar Proliferation: A Systematic Review of Current Literature.
Kowalewski A, Szylberg Ł, Skórczewska A, Marszałek A
Clin Genitourin Cancer 2016 Oct;14(5):361-365. Epub 2016 Feb 23 doi: 10.1016/j.clgc.2016.02.003. PMID: 26992486
Pulmonary preneoplasia.
Dacic S
Arch Pathol Lab Med 2008 Jul;132(7):1073-8. doi: 10.5858/2008-132-1073-PP. PMID: 18605763

Therapy

Ultrasound location of ground-glass opacity during thoracoscopic surgery.
Messina G, Bove M, Natale G, Noro A, Martone M, Opromolla G, Di Filippo V, Leonardi B, Fasano M, Polito R, Fiorelli A, Santini M, Vicidomini G
Interact Cardiovasc Thorac Surg 2022 Nov 8;35(6) doi: 10.1093/icvts/ivac234. PMID: 36063460Free PMC Article
Lung Findings in a Patient with a History of Nicotine Vaping and Cannabis Smoking.
McCormick W, Baykara Y, Siddique A, Van Truong L, Corbett M, Hacking SM
R I Med J (2013) 2022 Jun 1;105(5):36-40. PMID: 35617040
Predicting benign, preinvasive, and invasive lung nodules on computed tomography scans using machine learning.
Ashraf SF, Yin K, Meng CX, Wang Q, Wang Q, Pu J, Dhupar R
J Thorac Cardiovasc Surg 2022 Apr;163(4):1496-1505.e10. Epub 2021 Feb 16 doi: 10.1016/j.jtcvs.2021.02.010. PMID: 33726909
Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs.
Kohno T, Kakinuma R, Iwasaki M, Yamaji T, Kunitoh H, Suzuki K, Shimada Y, Shiraishi K, Kasuga Y, Hamada GS, Furuta K, Tsuta K, Sakamoto H, Kuchiba A, Yamamoto S, Kanai Y, Tsugane S, Yokota J
Carcinogenesis 2010 Oct;31(10):1794-9. Epub 2010 Aug 5 doi: 10.1093/carcin/bgq159. PMID: 20688833
Lung cancer preneoplasia.
Wistuba II, Gazdar AF
Annu Rev Pathol 2006;1:331-48. doi: 10.1146/annurev.pathol.1.110304.100103. PMID: 18039118

Prognosis

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.
Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Interstitial lung abnormalities: prognostic stratification of subtle radiological findings.
Silva M, Milanese G, Sverzellati N
Curr Opin Pulm Med 2018 Sep;24(5):432-439. doi: 10.1097/MCP.0000000000000497. PMID: 29939864
Facts and fiction: premalignant lesions of lung tissues.
Klebe S, Henderson DW
Pathology 2013 Apr;45(3):305-15. doi: 10.1097/PAT.0b013e32835f45fd. PMID: 23448809
Pulmonary preneoplasia.
Dacic S
Arch Pathol Lab Med 2008 Jul;132(7):1073-8. doi: 10.5858/2008-132-1073-PP. PMID: 18605763
Pathology of lung cancer.
Travis WD
Clin Chest Med 2002 Mar;23(1):65-81, viii. doi: 10.1016/s0272-5231(03)00061-3. PMID: 11901921

Clinical prediction guides

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.
Nie M, Yao K, Zhu X, Chen N, Xiao N, Wang Y, Peng B, Yao L, Li P, Zhang P, Hu Z
Nat Commun 2021 Nov 10;12(1):6479. doi: 10.1038/s41467-021-26685-y. PMID: 34759281Free PMC Article
Interstitial lung abnormalities: prognostic stratification of subtle radiological findings.
Silva M, Milanese G, Sverzellati N
Curr Opin Pulm Med 2018 Sep;24(5):432-439. doi: 10.1097/MCP.0000000000000497. PMID: 29939864
Increased expressions of claudin 4 and 7 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
Yamada G, Murata M, Takasawa A, Nojima M, Mori Y, Sawada N, Takahashi H
Med Mol Morphol 2016 Sep;49(3):163-9. Epub 2016 Feb 12 doi: 10.1007/s00795-016-0135-6. PMID: 26872891
Facts and fiction: premalignant lesions of lung tissues.
Klebe S, Henderson DW
Pathology 2013 Apr;45(3):305-15. doi: 10.1097/PAT.0b013e32835f45fd. PMID: 23448809
Precursors to pulmonary neoplasia.
Colby TV, Wistuba II, Gazdar A
Adv Anat Pathol 1998 Jul;5(4):205-15. doi: 10.1097/00125480-199807000-00001. PMID: 9859753

Recent systematic reviews

Diagnostic Difficulties With Atrophy, Atypical Adenomatous Hyperplasia, and Atypical Small Acinar Proliferation: A Systematic Review of Current Literature.
Kowalewski A, Szylberg Ł, Skórczewska A, Marszałek A
Clin Genitourin Cancer 2016 Oct;14(5):361-365. Epub 2016 Feb 23 doi: 10.1016/j.clgc.2016.02.003. PMID: 26992486

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