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Barrett adenocarcinoma

MedGen UID:
272350
Concept ID:
C1332460
Neoplastic Process
Synonyms: Adenocarcinoma Arising in Barrett's Mucosa; adenocarcinoma arising in Barrett's mucosa; Barrett Adenocarcinoma; Barrett's Adenocarcinoma; Barrett's adenocarcinoma
 
Monarch Initiative: MONDO:0004405

Definition

An adenocarcinoma arising from Barrett metaplastic epithelium in the esophagus. There is evidence supporting the idea that the Barrett adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy. Adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. In terms of grading, they are well or moderately differentiated adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBarrett adenocarcinoma

Professional guidelines

PubMed

Gong D, Lunz D, Stover JS, Meltzer SJ
Medicine (Baltimore) 2022 Sep 16;101(37):e30503. doi: 10.1097/MD.0000000000030503. PMID: 36123898Free PMC Article
Barnes JA, Willingham FF
J Clin Gastroenterol 2015 Sep;49(8):638-46. doi: 10.1097/MCG.0000000000000353. PMID: 26125458

Recent clinical studies

Etiology

Pizzi M, Fassan M, Realdon S, Balistreri M, Battaglia G, Giacometti C, Zaninotto G, Zagonel V, De Boni M, Rugge M
Hum Pathol 2012 Nov;43(11):1839-44. Epub 2012 Apr 20 doi: 10.1016/j.humpath.2012.01.004. PMID: 22521076
Konturek PC, Burnat G, Rau T, Hahn EG, Konturek S
Dig Dis Sci 2008 Mar;53(3):597-605. Epub 2007 Sep 1 doi: 10.1007/s10620-007-9922-1. PMID: 17763959
Casson AG, Zheng Z, Porter GA, Guernsey DL
Cancer Detect Prev 2006;30(5):423-31. Epub 2006 Oct 24 doi: 10.1016/j.cdp.2006.09.005. PMID: 17064856
Casson AG, Zheng Z, Evans SC, Veugelers PJ, Porter GA, Guernsey DL
Carcinogenesis 2005 Sep;26(9):1536-41. Epub 2005 May 5 doi: 10.1093/carcin/bgi115. PMID: 15878910
Sabel MS, Pastore K, Toon H, Smith JL
Arch Surg 2000 Jul;135(7):831-5; discussion 836. doi: 10.1001/archsurg.135.7.831. PMID: 10896378

Diagnosis

Maltby EL, Dyson MJ, Wheeler MR, Thomson M, Sethuraman C, Cohen MC
Pediatr Dev Pathol 2010 Jul-Aug;13(4):310-7. doi: 10.2350/09-08-0700-OA.1. PMID: 20053129
Takubo K, Aida J, Naomoto Y, Sawabe M, Arai T, Shiraishi H, Matsuura M, Ell C, May A, Pech O, Stolte M, Vieth M
Hum Pathol 2009 Jan;40(1):65-74. Epub 2008 Aug 27 doi: 10.1016/j.humpath.2008.06.008. PMID: 18755496
Shen B, Ormsby AH, Shen C, Dumot JA, Shao YW, Bevins CL, Gramlich TL
Cancer 2002 Feb 1;94(3):820-31. doi: 10.1002/cncr.10215. PMID: 11857318
Sabel MS, Pastore K, Toon H, Smith JL
Arch Surg 2000 Jul;135(7):831-5; discussion 836. doi: 10.1001/archsurg.135.7.831. PMID: 10896378

Therapy

Harai N, Ichijo M, Uchinuma H, Hanihara M, Kawaguchi Y, Ichikawa D, Tsuchiya K
Intern Med 2023 Oct 15;62(20):3005-3011. Epub 2023 Mar 8 doi: 10.2169/internalmedicine.1425-22. PMID: 36889706Free PMC Article
Prade E, Tobiasch M, Hitkova I, Schäffer I, Lian F, Xing X, Tänzer M, Rauser S, Walch A, Feith M, Post S, Röcken C, Schmid RM, Ebert MP, Burgermeister E
Mol Endocrinol 2012 May;26(5):819-32. Epub 2012 Apr 3 doi: 10.1210/me.2011-1140. PMID: 22474125Free PMC Article
Burnat G, Majka J, Konturek PC
J Physiol Pharmacol 2010 Apr;61(2):185-92. PMID: 20436219
Casson AG, Zheng Z, Porter GA, Guernsey DL
Cancer Detect Prev 2006;30(5):423-31. Epub 2006 Oct 24 doi: 10.1016/j.cdp.2006.09.005. PMID: 17064856
Collard JM
Cancer 2001 Mar 15;91(6):1098-104. PMID: 11267954

Prognosis

Casson AG, Zheng Z, Porter GA, Guernsey DL
Cancer Detect Prev 2006;30(5):423-31. Epub 2006 Oct 24 doi: 10.1016/j.cdp.2006.09.005. PMID: 17064856
Langer R, Specht K, Becker K, Ewald P, Bekesch M, Sarbia M, Busch R, Feith M, Stein HJ, Siewert JR, Höfler H
Clin Cancer Res 2005 Oct 15;11(20):7462-9. doi: 10.1158/1078-0432.CCR-05-0042. PMID: 16243820
Owonikoko T, Rees M, Gabbert HE, Sarbia M
Am J Clin Pathol 2002 Apr;117(4):558-66. doi: 10.1309/6XY8-FMM5-VVCJ-T3N0. PMID: 11939730
Collard JM
Cancer 2001 Mar 15;91(6):1098-104. PMID: 11267954
Sabel MS, Pastore K, Toon H, Smith JL
Arch Surg 2000 Jul;135(7):831-5; discussion 836. doi: 10.1001/archsurg.135.7.831. PMID: 10896378

Clinical prediction guides

Cook MB, Wood S, Hyland PL, Caron P, Drahos J, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Guillemette C, Murray LJ, Anderson LA
Andrology 2017 Mar;5(2):240-247. Epub 2017 Feb 27 doi: 10.1111/andr.12314. PMID: 28241109Free PMC Article
Almhanna K, Rosa M, Henderson-Jackson E, Jiang K, Shamekh R, Sayegh Z, Malafa MP, Coppola D
Appl Immunohistochem Mol Morphol 2016 Oct;24(9):633-638. doi: 10.1097/PAI.0000000000000243. PMID: 26186253Free PMC Article
Casson AG, Zheng Z, Porter GA, Guernsey DL
Cancer Detect Prev 2006;30(5):423-31. Epub 2006 Oct 24 doi: 10.1016/j.cdp.2006.09.005. PMID: 17064856
Langer R, Specht K, Becker K, Ewald P, Bekesch M, Sarbia M, Busch R, Feith M, Stein HJ, Siewert JR, Höfler H
Clin Cancer Res 2005 Oct 15;11(20):7462-9. doi: 10.1158/1078-0432.CCR-05-0042. PMID: 16243820
Varis A, Puolakkainen P, Savolainen H, Kokkola A, Salo J, Nieminen O, Nordling S, Knuutila S
Cancer Genet Cytogenet 2001 May;127(1):53-8. doi: 10.1016/s0165-4608(00)00423-4. PMID: 11408066

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