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Benign Apocrine Neoplasm

MedGen UID:
272352
•Concept ID:
C1332473
•
Neoplastic Process
Synonyms: Benign Apocrine Neoplasm of Skin; Benign Apocrine Neoplasm of the Skin; Benign Apocrine Skin Neoplasm; Benign Apocrine Skin Tumor; Benign Apocrine Tumor; Benign Apocrine Tumor of Skin; Benign Apocrine Tumor of the Skin

Definition

An epithelial neoplasm that arises from the apocrine glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Apocrine Neoplasm

Professional guidelines

PubMed

Current Management and Treatment of Extramammary Paget's Disease.
Hashimoto H, Ito T
Curr Treat Options Oncol 2022 Jun;23(6):818-830. Epub 2022 Apr 4 doi: 10.1007/s11864-021-00923-3. PMID: 35377101
Management of Mucoceles, Sialoceles, and Ranulas.
Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482
Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis.
Zhang YF, Li H, Wang XM, Cai YF
Eur Radiol 2019 Feb;29(2):725-735. Epub 2018 Jul 10 doi: 10.1007/s00330-018-5609-6. PMID: 29992386Free PMC Article

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Updated Salivary Gland Immunohistochemistry: A Review.
Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Carcinomas of the lacrimal drainage system.
Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Ceruminous Neoplasms of the Ear.
Nagarajan P
Head Neck Pathol 2018 Sep;12(3):350-361. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0909-3. PMID: 30069843Free PMC Article
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Therapy

Alcohol and Prostate Cancer: Time to Draw Conclusions.
Macke AJ, Petrosyan A
Biomolecules 2022 Feb 28;12(3) doi: 10.3390/biom12030375. PMID: 35327568Free PMC Article
Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.
Archer M, Dogra N, Dovey Z, Ganta T, Jang HS, Khusid JA, Lantz A, Mihalopoulos M, Stockert JA, Zahalka A, Björnebo L, Gaglani S, Noh MR, Kaplan SA, Mehrazin R, Badani KK, Wiklund P, Tsao K, Lundon DJ, Mohamed N, Lucien F, Padanilam B, Gupta M, Tewari AK, Kyprianou N
Cell Commun Signal 2021 Jul 20;19(1):78. doi: 10.1186/s12964-021-00755-6. PMID: 34284799Free PMC Article
Late-onset hypogonadism: Prostate safety.
Miranda EP, Torres LO
Andrology 2020 Nov;8(6):1606-1613. Epub 2020 Feb 28 doi: 10.1111/andr.12772. PMID: 32056383
Benign and malignant apocrine lesions of the breast.
Gerhard R, Costa JL, Schmitt F
Expert Rev Anticancer Ther 2012 Feb;12(2):215-21. doi: 10.1586/era.11.213. PMID: 22316369
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.
Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA
Cancer Discov 2011 Nov;1(6):487-95. doi: 10.1158/2159-8290.CD-11-0130. PMID: 22389870Free PMC Article

Prognosis

Salivary Gland-like Tumors of the Breast.
Richardson ET, Jo VY, Schnitt SJ
Arch Pathol Lab Med 2023 Sep 1;147(9):1014-1024. doi: 10.5858/arpa.2023-0038-RA. PMID: 37651394
A Comparative Review of Mixed Mammary Tumors in Mammals.
Saad ESA, Lam JSY, Al-Khan AA, Tayebi M, Day MJ, Richardson SJ, Danks JA
J Mammary Gland Biol Neoplasia 2019 Jun;24(2):125-137. Epub 2018 Nov 28 doi: 10.1007/s10911-018-9422-2. PMID: 30488318
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Malignant adnexal neoplasms.
Crowson AN, Magro CM, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S93-S126. doi: 10.1038/modpathol.3800511. PMID: 16446719

Clinical prediction guides

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Relevance of emerging metabolomics-based biomarkers of prostate cancer: a systematic review.
Bansal N, Kumar M, Sankhwar SN, Gupta A
Expert Rev Mol Med 2022 Jun 22;24:e25. doi: 10.1017/erm.2022.20. PMID: 35730322
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Molecular and diagnostic features of apocrine breast lesions.
Gromov P, Espinoza JA, Gromova I
Expert Rev Mol Diagn 2015;15(8):1011-22. Epub 2015 Jun 25 doi: 10.1586/14737159.2015.1057125. PMID: 26111757

Recent systematic reviews

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Diagnosis of parotid gland tumours with Contrast-Enhanced Ultrasound: a systematic review and meta-analysis.
Sultan SR, AlKharaiji M, Rajab SH
Med Ultrason 2022 May 25;24(2):211-218. Epub 2021 Jul 21 doi: 10.11152/mu-3119. PMID: 34216453
Surgical interventions for management of benign parotid tumors: Systematic review and network meta-analysis.
Mashrah MA, Al-Sharani HM, Al-Aroomi MA, Abdelrehem A, Aldhohrah T, Wang L
Head Neck 2021 Nov;43(11):3631-3645. Epub 2021 Jul 20 doi: 10.1002/hed.26813. PMID: 34288212
Comparison of core needle biopsy and fine-needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta-analysis.
Cho J, Kim J, Lee JS, Chee CG, Kim Y, Choi SI
Head Neck 2020 Oct;42(10):3041-3050. Epub 2020 Jul 16 doi: 10.1002/hed.26377. PMID: 32671867
Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956

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