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Childhood Benign Germ Cell Tumor

MedGen UID:
272354
Concept ID:
C1332485
Neoplastic Process
Synonyms: Benign Childhood Germ Cell Neoplasm; Benign Childhood Germ Cell Tumor; Benign Pediatric Germ Cell Neoplasm; Benign Pediatric Germ Cell Tumor

Definition

A germ cell tumor that occurs during childhood and is characterized by the absence of atypia and metastatic potential. [from NCI]

Professional guidelines

PubMed

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
MacCollin M, Mautner VF
Semin Pediatr Neurol 1998 Dec;5(4):243-52. doi: 10.1016/s1071-9091(98)80003-x. PMID: 9874852

Recent clinical studies

Etiology

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Balogun JA, Rutka JT
Prog Neurol Surg 2018;30:204-217. Epub 2017 Dec 14 doi: 10.1159/000464437. PMID: 29241176
Ardern-Holmes S, Fisher G, North K
J Child Neurol 2017 Jan;32(1):9-22. Epub 2016 Sep 29 doi: 10.1177/0883073816666736. PMID: 27655473

Diagnosis

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Mende KC, Pantel TF, Flitsch J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):172-177. Epub 2020 Aug 4 doi: 10.1055/a-1217-7282. PMID: 32750720
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
McCrea HJ, George E, Settler A, Schwartz TH, Greenfield JP
J Child Neurol 2016 Oct;31(12):1367-76. Epub 2015 Dec 15 doi: 10.1177/0883073815620671. PMID: 26676303

Therapy

Nguyen Quoc A, Beccaria K, González Briceño L, Pinto G, Samara-Boustani D, Stoupa A, Beltrand J, Besançon A, Thalassinos C, Puget S, Blauwblomme T, Alapetite C, Bolle S, Doz F, Grill J, Dufour C, Bourdeaut F, Abbou S, Guerrini-Rousseau L, Leruste A, Brabant S, Cavadias I, Viaud M, Boddaert N, Polak M, Kariyawasam D
J Clin Endocrinol Metab 2023 Jul 14;108(8):1929-1936. doi: 10.1210/clinem/dgad079. PMID: 36794424
Slade AD, Austin MT
Curr Opin Pediatr 2014 Jun;26(3):356-61. doi: 10.1097/MOP.0000000000000082. PMID: 24786371
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685

Prognosis

Zhang Y, Ma Y, Liu Q, Du Y, Peng L, Zhou J, Zhao Z, Li C, Wang S
Front Immunol 2023;14:1197773. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1197773. PMID: 37790931Free PMC Article
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Mende KC, Pantel TF, Flitsch J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):172-177. Epub 2020 Aug 4 doi: 10.1055/a-1217-7282. PMID: 32750720
Balogun JA, Rutka JT
Prog Neurol Surg 2018;30:204-217. Epub 2017 Dec 14 doi: 10.1159/000464437. PMID: 29241176
Rescorla FJ
Semin Pediatr Surg 2006 Feb;15(1):48-56. doi: 10.1053/j.sempedsurg.2005.11.008. PMID: 16458846

Clinical prediction guides

Nguyen Quoc A, Beccaria K, González Briceño L, Pinto G, Samara-Boustani D, Stoupa A, Beltrand J, Besançon A, Thalassinos C, Puget S, Blauwblomme T, Alapetite C, Bolle S, Doz F, Grill J, Dufour C, Bourdeaut F, Abbou S, Guerrini-Rousseau L, Leruste A, Brabant S, Cavadias I, Viaud M, Boddaert N, Polak M, Kariyawasam D
J Clin Endocrinol Metab 2023 Jul 14;108(8):1929-1936. doi: 10.1210/clinem/dgad079. PMID: 36794424
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Haupt R, Magnani C, Pavanello M, Caruso S, Dama E, Garrè ML
J Pediatr Endocrinol Metab 2006 Apr;19 Suppl 1:289-93. PMID: 16700303
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685

Recent systematic reviews

Jamshidi AM, Soldozy S, Elarjani T, Burks JD, Luther E, Starke RM
World Neurosurg 2022 Jun;162:77-84. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.058. PMID: 34555575
Zhang S, Fang Y, Cai BW, Xu JG, You C
Cochrane Database Syst Rev 2016 Jul 14;7(7):CD008890. doi: 10.1002/14651858.CD008890.pub4. PMID: 27416004Free PMC Article
Zheng J, Fang Y, Cai BW, Zhang H, Liu W, Wu B, Xu JG, You C
Cochrane Database Syst Rev 2014 Sep 19;(9):CD008890. doi: 10.1002/14651858.CD008890.pub3. PMID: 25233847
Liu W, Fang Y, Cai B, Xu J, You C, Zhang H
Neurosurgery 2012 Nov;71(5):909-15. doi: 10.1227/NEU.0b013e31826d5c31. PMID: 22902333
Grill J, Pascal C, Chantal K
Paediatr Drugs 2003;5(8):533-43. doi: 10.2165/00148581-200305080-00004. PMID: 12895136

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