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Benign Childhood Germ Cell Tumor

MedGen UID:
272354
•Concept ID:
C1332485
•
Neoplastic Process
Synonyms: Benign Childhood Germ Cell Neoplasm; Benign Pediatric Germ Cell Neoplasm; Benign Pediatric Germ Cell Tumor

Definition

A non-metastasizing germ cell tumor that occurs during childhood. [from NCI]

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Intraocular medulloepithelioma - A review of clinical features, DICER 1 mutation, and management.
Tadepalli SH, Shields CL, Shields JA, Honavar SG
Indian J Ophthalmol 2019 Jun;67(6):755-762. doi: 10.4103/ijo.IJO_845_19. PMID: 31124483Free PMC Article
The diagnosis and management of neurofibromatosis 2 in childhood.
MacCollin M, Mautner VF
Semin Pediatr Neurol 1998 Dec;5(4):243-52. doi: 10.1016/s1071-9091(98)80003-x. PMID: 9874852

Recent clinical studies

Etiology

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Coexistence of craniopharyngioma and cranial fibrous dysplasia: a case series of clinicopathological study.
Fan YH, Li Z
Orphanet J Rare Dis 2022 Mar 18;17(1):126. doi: 10.1186/s13023-022-02281-1. PMID: 35303908Free PMC Article
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Surgery of Intracranial Gliomas in Children.
Balogun JA, Rutka JT
Prog Neurol Surg 2018;30:204-217. Epub 2017 Dec 14 doi: 10.1159/000464437. PMID: 29241176
Neurofibromatosis Type 2.
Ardern-Holmes S, Fisher G, North K
J Child Neurol 2017 Jan;32(1):9-22. Epub 2016 Sep 29 doi: 10.1177/0883073816666736. PMID: 27655473

Diagnosis

Orbital dermoid cyst.
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Neurofibromatosis Type 2.
Ardern-Holmes S, Fisher G, North K
J Child Neurol 2017 Jan;32(1):9-22. Epub 2016 Sep 29 doi: 10.1177/0883073816666736. PMID: 27655473
Pediatric Suprasellar Tumors.
McCrea HJ, George E, Settler A, Schwartz TH, Greenfield JP
J Child Neurol 2016 Oct;31(12):1367-76. Epub 2015 Dec 15 doi: 10.1177/0883073815620671. PMID: 26676303
Surgery for craniopharyngioma.
Buchfelder M, Schlaffer SM, Lin F, Kleindienst A
Pituitary 2013 Mar;16(1):18-25. doi: 10.1007/s11102-012-0414-8. PMID: 22836237

Therapy

GH and Childhood-onset Craniopharyngioma: When to Initiate GH Replacement Therapy?
Nguyen Quoc A, Beccaria K, González Briceño L, Pinto G, Samara-Boustani D, Stoupa A, Beltrand J, Besançon A, Thalassinos C, Puget S, Blauwblomme T, Alapetite C, Bolle S, Doz F, Grill J, Dufour C, Bourdeaut F, Abbou S, Guerrini-Rousseau L, Leruste A, Brabant S, Cavadias I, Viaud M, Boddaert N, Polak M, Kariyawasam D
J Clin Endocrinol Metab 2023 Jul 14;108(8):1929-1936. doi: 10.1210/clinem/dgad079. PMID: 36794424
Childhood melanoma: an increasingly important health problem in the USA.
Slade AD, Austin MT
Curr Opin Pediatr 2014 Jun;26(3):356-61. doi: 10.1097/MOP.0000000000000082. PMID: 24786371
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Craniopharyngiomas.
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Genetic parameters of neuroblastomas.
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685

Prognosis

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Revived Attention for Adult Craniopharyngioma.
Mende KC, Pantel TF, Flitsch J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):172-177. Epub 2020 Aug 4 doi: 10.1055/a-1217-7282. PMID: 32750720
Craniopharyngiomas.
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Malignant adrenal tumors.
Rescorla FJ
Semin Pediatr Surg 2006 Feb;15(1):48-56. doi: 10.1053/j.sempedsurg.2005.11.008. PMID: 16458846
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Clinical prediction guides

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Cancer and Central Nervous System Tumor Surveillance in Pediatric Neurofibromatosis 2 and Related Disorders.
Evans DGR, Salvador H, Chang VY, Erez A, Voss SD, Druker H, Scott HS, Tabori U
Clin Cancer Res 2017 Jun 15;23(12):e54-e61. doi: 10.1158/1078-0432.CCR-17-0590. PMID: 28620005
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Craniopharyngiomas.
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Recent systematic reviews

Fusiform Dilatation of the Internal Carotid Artery in Childhood-Onset Craniopharyngioma: A Systematic Review.
Jamshidi AM, Soldozy S, Elarjani T, Burks JD, Luther E, Starke RM
World Neurosurg 2022 Jun;162:77-84. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.058. PMID: 34555575
Intracystic bleomycin for cystic craniopharyngiomas in children.
Zhang S, Fang Y, Cai BW, Xu JG, You C
Cochrane Database Syst Rev 2016 Jul 14;7(7):CD008890. doi: 10.1002/14651858.CD008890.pub4. PMID: 27416004Free PMC Article
Intracystic bleomycin for cystic craniopharyngiomas in children.
Zheng J, Fang Y, Cai BW, Zhang H, Liu W, Wu B, Xu JG, You C
Cochrane Database Syst Rev 2014 Sep 19;(9):CD008890. doi: 10.1002/14651858.CD008890.pub3. PMID: 25233847
Intracystic bleomycin for cystic craniopharyngiomas in children.
Fang Y, Cai BW, Zhang H, Liu W, Wu B, Xu JG, You C
Cochrane Database Syst Rev 2012 Apr 18;(4):CD008890. doi: 10.1002/14651858.CD008890.pub2. PMID: 22513968
Childhood ependymoma: a systematic review of treatment options and strategies.
Grill J, Pascal C, Chantal K
Paediatr Drugs 2003;5(8):533-43. doi: 10.2165/00148581-200305080-00004. PMID: 12895136

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