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Benign Ovarian Seromucinous Tumor

MedGen UID:
272361
•Concept ID:
C1332525
•
Neoplastic Process
Synonym: Benign Seromucinous Cystadenoma/Adenofibroma

Definition

A non-metastasizing mixed epithelial neoplasm that arises from the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous. There is no evidence of atypia. This category includes seromucinous cystadenoma and seromucinous adenofibroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Ovarian Seromucinous Tumor

Professional guidelines

PubMed

Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice.
Ohya A, Fujinaga Y
Jpn J Radiol 2022 Dec;40(12):1213-1234. Epub 2022 Aug 2 doi: 10.1007/s11604-022-01321-x. PMID: 35916971Free PMC Article
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Recent clinical studies

Etiology

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
Metachronous benign ovarian tumors are not uncommon in children.
Taskinen S, Urtane A, Fagerholm R, Lohi J, Taskinen M
J Pediatr Surg 2014 Apr;49(4):543-5. Epub 2013 Oct 3 doi: 10.1016/j.jpedsurg.2013.09.019. PMID: 24726109
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Diagnosis

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Ovarian seromucinous tumors: clinicopathological features of 10 cases with a detailed review of the literature.
Idrees R, Din NU, Siddique S, Fatima S, Abdul-Ghafar J, Ahmad Z
J Ovarian Res 2021 Mar 18;14(1):47. doi: 10.1186/s13048-021-00796-y. PMID: 33736662Free PMC Article
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216
Metachronous benign ovarian tumors are not uncommon in children.
Taskinen S, Urtane A, Fagerholm R, Lohi J, Taskinen M
J Pediatr Surg 2014 Apr;49(4):543-5. Epub 2013 Oct 3 doi: 10.1016/j.jpedsurg.2013.09.019. PMID: 24726109

Therapy

New sonographic marker of borderline ovarian tumor: microcystic pattern of papillae and solid components.
Timor-Tritsch IE, Foley CE, Brandon C, Yoon E, Ciaffarrano J, Monteagudo A, Mittal K, Boyd L
Ultrasound Obstet Gynecol 2019 Sep;54(3):395-402. Epub 2019 Aug 8 doi: 10.1002/uog.20283. PMID: 30950132
Oral contraceptive use and benign gynecologic conditions. A review.
Chiaffarino F, Parazzini F, La Vecchia C, Ricci E, Crosignani PG
Contraception 1998 Jan;57(1):11-8. doi: 10.1016/s0010-7824(97)00201-1. PMID: 9554245
Risk factors for seromucinous benign ovarian cysts in northern Italy.
Parazzini F, Moroni S, Negri E, La Vecchia C, Mezzopane R, Crosignani PG
J Epidemiol Community Health 1997 Aug;51(4):449-52. doi: 10.1136/jech.51.4.449. PMID: 9328556Free PMC Article

Prognosis

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Rare Presentation of Giant Ovarian Cyst.
Shrestha Prajapati S, Shrestha A, Bade Shrestha U
J Nepal Health Res Counc 2022 Mar 13;19(4):849-851. doi: 10.33314/jnhrc.v19i04.3851. PMID: 35615849
The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications.
Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J
Arch Gynecol Obstet 2016 Apr;293(4):695-700. Epub 2016 Feb 19 doi: 10.1007/s00404-016-4035-8. PMID: 26894303
Metachronous benign ovarian tumors are not uncommon in children.
Taskinen S, Urtane A, Fagerholm R, Lohi J, Taskinen M
J Pediatr Surg 2014 Apr;49(4):543-5. Epub 2013 Oct 3 doi: 10.1016/j.jpedsurg.2013.09.019. PMID: 24726109
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Clinical prediction guides

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice.
Ohya A, Fujinaga Y
Jpn J Radiol 2022 Dec;40(12):1213-1234. Epub 2022 Aug 2 doi: 10.1007/s11604-022-01321-x. PMID: 35916971Free PMC Article
New sonographic marker of borderline ovarian tumor: microcystic pattern of papillae and solid components.
Timor-Tritsch IE, Foley CE, Brandon C, Yoon E, Ciaffarrano J, Monteagudo A, Mittal K, Boyd L
Ultrasound Obstet Gynecol 2019 Sep;54(3):395-402. Epub 2019 Aug 8 doi: 10.1002/uog.20283. PMID: 30950132
Metachronous benign ovarian tumors are not uncommon in children.
Taskinen S, Urtane A, Fagerholm R, Lohi J, Taskinen M
J Pediatr Surg 2014 Apr;49(4):543-5. Epub 2013 Oct 3 doi: 10.1016/j.jpedsurg.2013.09.019. PMID: 24726109
Serous and seromucinous infantile ovarian cystadenomas--a study of 42 cases.
Massicot R, Rousseau V, Darwish AA, Sauvat F, Jaubert F, Nihoul-Fékété C
Eur J Obstet Gynecol Reprod Biol 2009 Jan;142(1):64-7. Epub 2008 Nov 8 doi: 10.1016/j.ejogrb.2008.09.007. PMID: 18996636

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