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Salivary Gland Carcinosarcoma

MedGen UID:
272435
•Concept ID:
C1332842
•
Neoplastic Process
Synonyms: Carcinosarcoma of Salivary Gland; Carcinosarcoma of the Salivary Gland; True Malignant Mixed Tumor of the Salivary Gland

Definition

An aggressive, high grade malignant tumor that arises from the salivary gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Carcinosarcoma

Recent clinical studies

Etiology

A case-control analysis of survival outcomes in sinonasal carcinosarcoma.
Patel TD, Vázquez A, Plitt MA, Baredes S, Eloy JA
Am J Otolaryngol 2015 Mar-Apr;36(2):200-4. Epub 2014 Oct 31 doi: 10.1016/j.amjoto.2014.10.031. PMID: 25465656
Salivary gland carcinosarcoma: oligonucleotide array CGH reveals similar genomic profiles in epithelial and mesenchymal components.
Vékony H, Leemans CR, Ylstra B, Meijer GA, van der Waal I, Bloemena E
Oral Oncol 2009 Mar;45(3):259-65. Epub 2008 Aug 6 doi: 10.1016/j.oraloncology.2008.05.009. PMID: 18693132

Diagnosis

Carcinosarcoma de novo of the parotid gland: case report.
Taki NH, Laver N, Quinto T, Wein RO
Head Neck 2013 May;35(5):E161-3. Epub 2012 Feb 6 doi: 10.1002/hed.22900. PMID: 22307836
Carcinosarcoma de novo of the parotid gland.
Staffieri C, Marioni G, Ferraro SM, Marino F, Staffieri A
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Aug;104(2):e35-40. Epub 2006 Oct 27 doi: 10.1016/j.tripleo.2006.06.055. PMID: 17630097
MRI findings of carcinosarcoma in the parotid gland.
Fan KF, Connor SE, Macbean AD, Langdon JD
Oral Oncol 2006 Mar;42(3):323-6. Epub 2005 Oct 25 doi: 10.1016/j.oraloncology.2005.06.023. PMID: 16253544
Initial report of a case of carcinosarcoma of the supraglottis.
Ernster JA, Franquemont DW, Sweeney JP
Ear Nose Throat J 2000 May;79(5):384-7. PMID: 10832205
Carcinosarcoma of salivary glands with unusual stromal components. Report of two cases and review of the literature.
Carson HJ, Tojo DP, Chow JM, Hammadeh R, Raslan WF
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Jun;79(6):738-46. doi: 10.1016/s1079-2104(05)80309-9. PMID: 7621032

Therapy

Carcinosarcoma de novo of the parotid gland.
Staffieri C, Marioni G, Ferraro SM, Marino F, Staffieri A
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Aug;104(2):e35-40. Epub 2006 Oct 27 doi: 10.1016/j.tripleo.2006.06.055. PMID: 17630097

Prognosis

A case-control analysis of survival outcomes in sinonasal carcinosarcoma.
Patel TD, Vázquez A, Plitt MA, Baredes S, Eloy JA
Am J Otolaryngol 2015 Mar-Apr;36(2):200-4. Epub 2014 Oct 31 doi: 10.1016/j.amjoto.2014.10.031. PMID: 25465656
Carcinosarcoma de novo of the parotid gland: case report.
Taki NH, Laver N, Quinto T, Wein RO
Head Neck 2013 May;35(5):E161-3. Epub 2012 Feb 6 doi: 10.1002/hed.22900. PMID: 22307836
Initial report of a case of carcinosarcoma of the supraglottis.
Ernster JA, Franquemont DW, Sweeney JP
Ear Nose Throat J 2000 May;79(5):384-7. PMID: 10832205
Carcinosarcoma of the submandibular salivary gland.
Gogas J, Markopoulos C, Karydakis V, Gogas G, Delladetsima J
Eur J Surg Oncol 1999 Jun;25(3):333-5. PMID: 10383250

Clinical prediction guides

Salivary gland carcinosarcoma: oligonucleotide array CGH reveals similar genomic profiles in epithelial and mesenchymal components.
Vékony H, Leemans CR, Ylstra B, Meijer GA, van der Waal I, Bloemena E
Oral Oncol 2009 Mar;45(3):259-65. Epub 2008 Aug 6 doi: 10.1016/j.oraloncology.2008.05.009. PMID: 18693132

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