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Central nervous system immature teratoma

MedGen UID:
272442
Concept ID:
C1332883
Neoplastic Process
Synonyms: Central Nervous System Immature Teratoma; central nervous system immature teratoma; CNS Immature Teratoma; CNS immature teratoma; immature teratoma; Immature Teratoma of Central Nervous System; immature teratoma of central nervous system; Immature Teratoma of CNS; immature teratoma of CNS; Immature Teratoma of the Central Nervous System; immature teratoma of the central nervous system; Immature Teratoma of the CNS; immature teratoma of the CNS
 
Monarch Initiative: MONDO:0003735

Definition

A teratoma involving the central nervous system and characterized by the presence of an extensive component of immature, fetal-type tissues. [from NCI]

Professional guidelines

PubMed

Tanacan A, Ozgen B, Fadiloglu E, Unal C, Oguz KK, Beksac MS
Eur J Obstet Gynecol Reprod Biol 2020 Jul;250:195-202. Epub 2020 May 13 doi: 10.1016/j.ejogrb.2020.05.013. PMID: 32460228
Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, Gleichman AJ, Balice-Gordon R, Rosenfeld MR, Lynch D, Graus F, Dalmau J
Lancet Neurol 2014 Feb;13(2):167-77. Epub 2013 Dec 18 doi: 10.1016/S1474-4422(13)70282-5. PMID: 24360484Free PMC Article
Hwang SW, Su JM, Jea A
Semin Fetal Neonatal Med 2012 Aug;17(4):202-206. Epub 2012 Mar 30 doi: 10.1016/j.siny.2012.03.001. PMID: 22465555

Recent clinical studies

Etiology

Harris MK, Graham RT, Cappellano AM, Margol AS, Michaiel G, Crawford JR, Ioakeim-Ioannidou M, Stanek JR, Liu KX, MacDonald SM, Abdelbaki MS
Pediatr Blood Cancer 2022 Oct;69(10):e29830. Epub 2022 Jun 10 doi: 10.1002/pbc.29830. PMID: 35686831
McGovern SL, Grosshans D, Mahajan A
Cancer J 2014 Nov-Dec;20(6):397-402. doi: 10.1097/PPO.0000000000000081. PMID: 25415685
Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, Gleichman AJ, Balice-Gordon R, Rosenfeld MR, Lynch D, Graus F, Dalmau J
Lancet Neurol 2014 Feb;13(2):167-77. Epub 2013 Dec 18 doi: 10.1016/S1474-4422(13)70282-5. PMID: 24360484Free PMC Article
Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046

Diagnosis

Blessing MM, Alexandrescu S
Surg Pathol Clin 2020 Jun;13(2):235-247. Epub 2020 Apr 7 doi: 10.1016/j.path.2020.01.003. PMID: 32389264
Chaturvedi A, Franco A, Chaturvedi A, Klionsky NB
Clin Imaging 2018 Nov-Dec;52:216-225. Epub 2018 Jul 21 doi: 10.1016/j.clinimag.2018.07.014. PMID: 30138861
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070
Hwang SW, Su JM, Jea A
Semin Fetal Neonatal Med 2012 Aug;17(4):202-206. Epub 2012 Mar 30 doi: 10.1016/j.siny.2012.03.001. PMID: 22465555
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046

Therapy

Alva E, Rubens J, Chi S, Rosenberg T, Reddy A, Raabe EH, Margol A
Neoplasia 2023 Mar;37:100880. Epub 2023 Feb 9 doi: 10.1016/j.neo.2023.100880. PMID: 36773516Free PMC Article
Blessing MM, Alexandrescu S
Surg Pathol Clin 2020 Jun;13(2):235-247. Epub 2020 Apr 7 doi: 10.1016/j.path.2020.01.003. PMID: 32389264
Theruvath J, Sotillo E, Mount CW, Graef CM, Delaidelli A, Heitzeneder S, Labanieh L, Dhingra S, Leruste A, Majzner RG, Xu P, Mueller S, Yecies DW, Finetti MA, Williamson D, Johann PD, Kool M, Pfister S, Hasselblatt M, Frühwald MC, Delattre O, Surdez D, Bourdeaut F, Puget S, Zaidi S, Mitra SS, Cheshier S, Sorensen PH, Monje M, Mackall CL
Nat Med 2020 May;26(5):712-719. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0821-8. PMID: 32341579Free PMC Article
Linnoila J, Pittock SJ
Semin Neurol 2016 Aug;36(4):382-96. Epub 2016 Sep 19 doi: 10.1055/s-0036-1585453. PMID: 27643908
McGovern SL, Grosshans D, Mahajan A
Cancer J 2014 Nov-Dec;20(6):397-402. doi: 10.1097/PPO.0000000000000081. PMID: 25415685

Prognosis

González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Blessing MM, Alexandrescu S
Surg Pathol Clin 2020 Jun;13(2):235-247. Epub 2020 Apr 7 doi: 10.1016/j.path.2020.01.003. PMID: 32389264
Traisrisilp K, Srisupundit K, Suwansirikul S, Norasetthada T, Kosarat S, Tongsong T
J Clin Ultrasound 2018 Sep;46(7):487-493. Epub 2017 Nov 28 doi: 10.1002/jcu.22566. PMID: 29193240
Flanagan EP, Hinson SR, Lennon VA, Fang B, Aksamit AJ, Morris PP, Basal E, Honorat JA, Alfugham NB, Linnoila JJ, Weinshenker BG, Pittock SJ, McKeon A
Ann Neurol 2017 Feb;81(2):298-309. doi: 10.1002/ana.24881. PMID: 28120349
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202

Clinical prediction guides

Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Flanagan EP, Hinson SR, Lennon VA, Fang B, Aksamit AJ, Morris PP, Basal E, Honorat JA, Alfugham NB, Linnoila JJ, Weinshenker BG, Pittock SJ, McKeon A
Ann Neurol 2017 Feb;81(2):298-309. doi: 10.1002/ana.24881. PMID: 28120349
Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, Gleichman AJ, Balice-Gordon R, Rosenfeld MR, Lynch D, Graus F, Dalmau J
Lancet Neurol 2014 Feb;13(2):167-77. Epub 2013 Dec 18 doi: 10.1016/S1474-4422(13)70282-5. PMID: 24360484Free PMC Article
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202

Recent systematic reviews

Vasilevska V, Guest PC, Szardenings M, Benros ME, Steiner J
Transl Psychiatry 2024 Mar 8;14(1):139. doi: 10.1038/s41398-024-02831-0. PMID: 38459000Free PMC Article
Hazneci J, Bastacı F, Börekci A, Öztürk ÖÇ, İş M, Somay A, Ekşi MŞ, Çelikoğlu E
Childs Nerv Syst 2022 Oct;38(10):1977-1986. Epub 2022 Jun 10 doi: 10.1007/s00381-022-05578-5. PMID: 35687168
Egiz A, Kannan S, Asl SF
World Neurosurg 2022 Aug;164:216-227. Epub 2022 Apr 22 doi: 10.1016/j.wneu.2022.04.073. PMID: 35470083
Broggi G, Gianno F, Shemy DT, Massimino M, Milanaccio C, Mastronuzzi A, Rossi S, Arcella A, Giangaspero F, Antonelli M
J Neurooncol 2022 Mar;157(1):1-14. Epub 2022 Feb 25 doi: 10.1007/s11060-022-03959-z. PMID: 35217948
Tolebeyan AS, Kuruvilla DE
Curr Pain Headache Rep 2020 May 29;24(7):31. doi: 10.1007/s11916-020-00863-x. PMID: 32472229

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