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Central Nervous System T-Cell Non-Hodgkin Lymphoma

MedGen UID:
272445
•Concept ID:
C1332894
•
Neoplastic Process
Synonyms: Central Nervous System T-Cell and NK-Cell Non-Hodgkin's Lymphoma; Central Nervous System T-Cell Lymphoma; Central Nervous System T-Cell Non-Hodgkin's Lymphoma; CNS T-Cell Lymphoma; Primary Central Nervous System T-Cell Non-Hodgkin's Lymphoma; T-Cell Lymphoma of Central Nervous System; T-Cell Lymphoma of CNS; T-Cell Lymphoma of the Central Nervous System; T-Cell Lymphoma of the CNS

Definition

A T-cell lymphoblastic lymphoma or a mature T-cell and NK-cell neoplasm that affects the brain, meninges, or spinal cord. [from NCI]

Professional guidelines

PubMed

Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article

Recent clinical studies

Etiology

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
CAR T-cell therapy in large B cell lymphoma.
Boardman AP, Salles G
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):112-118. doi: 10.1002/hon.3153. PMID: 37294963Free PMC Article
Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639

Diagnosis

Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma.
Heming M, Haessner S, Wolbert J, Lu IN, Li X, Brokinkel B, Müther M, Holling M, Stummer W, Thomas C, Schulte-Mecklenbeck A, de Faria F, Stoeckius M, Hailfinger S, Lenz G, Kerl K, Wiendl H, Meyer Zu Hörste G, Grauer OM
Genome Med 2022 Sep 24;14(1):109. doi: 10.1186/s13073-022-01110-1. PMID: 36153593Free PMC Article
T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292Free PMC Article
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Therapy

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
CAR T-cell therapy in large B cell lymphoma.
Boardman AP, Salles G
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):112-118. doi: 10.1002/hon.3153. PMID: 37294963Free PMC Article
Treatment Options for Recurrent Primary CNS Lymphoma.
Kaulen LD, Baehring JM
Curr Treat Options Oncol 2022 Nov;23(11):1548-1565. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01016-5. PMID: 36205806
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article

Prognosis

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Śliwa-Tytko P, Kaczmarska A, Lejman M, Zawitkowska J
Int J Mol Sci 2022 May 15;23(10) doi: 10.3390/ijms23105515. PMID: 35628334Free PMC Article
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639

Clinical prediction guides

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Safety and efficacy of tisagenlecleucel in primary CNS lymphoma: a phase 1/2 clinical trial.
Frigault MJ, Dietrich J, Gallagher K, Roschewski M, Jordan JT, Forst D, Plotkin SR, Cook D, Casey KS, Lindell KA, Depinho GD, Katsis K, Elder EL, Leick MB, Choi B, Horick N, Preffer F, Saylor M, McAfee S, O'Donnell PV, Spitzer TR, Dey B, DeFilipp Z, El-Jawahri A, Batchelor TT, Maus MV, Chen YB
Blood 2022 Apr 14;139(15):2306-2315. doi: 10.1182/blood.2021014738. PMID: 35167655Free PMC Article
STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Recent systematic reviews

Chimeric Antigen Receptor T - Cell Therapy for Large B-Cell Lymphoma Patients with Central Nervous System Involvement, a Systematic Review and Meta-analysis.
Elgohary G, Yang Y, Gergis M, Yi D, Gergis U
Clin Lymphoma Myeloma Leuk 2024 Apr;24(4):e142-e151. Epub 2024 Jan 12 doi: 10.1016/j.clml.2023.12.012. PMID: 38267353
Chimeric Antigen Receptor T-Cell (CAR T-Cell) Therapy for Primary and Secondary Central Nervous System Lymphoma: A Systematic Review of Literature.
Asghar N, Masood A, Dhaliwal A, Khurana S, Davis J, Hashmi H, Husnain M
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):15-21. Epub 2022 Oct 7 doi: 10.1016/j.clml.2022.09.008. PMID: 36328891
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Primary pituitary lymphoma: an update of the literature.
Tarabay A, Cossu G, Berhouma M, Levivier M, Daniel RT, Messerer M
J Neurooncol 2016 Dec;130(3):383-395. Epub 2016 Aug 31 doi: 10.1007/s11060-016-2249-z. PMID: 27581598
Lymphomatosis cerebri: a rare form of primary central nervous system lymphoma. Analysis of 7 cases and systematic review of the literature.
Izquierdo C, Velasco R, Vidal N, Sánchez JJ, Argyriou AA, Besora S, Graus F, Bruna J
Neuro Oncol 2016 May;18(5):707-15. Epub 2015 Sep 27 doi: 10.1093/neuonc/nov197. PMID: 26415875Free PMC Article

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