U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Central breast papilloma

MedGen UID:
272446
•Concept ID:
C1332896
•
Neoplastic Process
Synonyms: Breast Central Papilloma; Central Breast Papilloma; central breast papilloma; Large Duct Breast Papilloma; large duct breast papilloma; Solitary Intraductal Breast Papilloma; solitary intraductal breast papilloma
 
Monarch Initiative: MONDO:0004505

Definition

A benign papillary neoplasm that arises in a large duct of the breast. It is characterized by the presence of a fibrovascular core that is lined by benign epithelial and myoepithelial proliferations. Patients usually present with nipple discharge. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral breast papilloma

Professional guidelines

PubMed

Safety and effectiveness of microdebrider bronchoscopy for the management of central airway obstruction.
Casal RF, Iribarren J, Eapen G, Ost D, Morice R, Lan C, Cornwell L, Almeida FA, Grosu H, Jimenez CA
Respirology 2013 Aug;18(6):1011-5. doi: 10.1111/resp.12087. PMID: 23520982
Papillary secretion. Diagnostic assessment and treatment.
Ingvar C
Scand J Surg 2002;91(3):246-50. doi: 10.1177/145749690209100306. PMID: 12449466
Incidental treatment of nipple discharge caused by benign intraductal papilloma through diagnostic Mammotome biopsy.
Dennis MA, Parker S, Kaske TI, Stavros AT, Camp J
AJR Am J Roentgenol 2000 May;174(5):1263-8. doi: 10.2214/ajr.174.5.1741263. PMID: 10789774

Recent clinical studies

Etiology

Papillary Lesions of the Breast: Addition of DWI and TIRM Sequences to Routine Breast MRI Could Help in Differentiation Benign from Malignant.
Gültekin MA, Yabul FÇ, Temur HO, Sari L, Yilmaz TF, Toprak H, Yildiz S
Curr Med Imaging 2022;18(9):962-969. doi: 10.2174/1573405618666220218101931. PMID: 35184715
Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters.
Zhang H, Sun Y, Zhang J, Wang S
Ultrasound Med Biol 2021 Apr;47(4):960-966. Epub 2021 Jan 15 doi: 10.1016/j.ultrasmedbio.2020.12.005. PMID: 33455809
Papillomas of the breast: factors associated with underestimation.
Boufelli G, Giannotti MA, Ruiz CA, Barros N, Chala LF, Maesaka JY, Goncalves R, Bresciani BH, Vianna P, Soares JM Jr, Baracat EC, Filassi JR
Eur J Cancer Prev 2018 Jul;27(4):310-314. doi: 10.1097/CEJ.0000000000000343. PMID: 28296665Free PMC Article
Nipple discharge: current diagnostic and therapeutic approaches.
Sakorafas GH
Cancer Treat Rev 2001 Oct;27(5):275-82. doi: 10.1053/ctrv.2001.0234. PMID: 11871863
Health hazards of obesity.
Bray GA
Endocrinol Metab Clin North Am 1996 Dec;25(4):907-19. doi: 10.1016/s0889-8529(05)70361-3. PMID: 8977052

Diagnosis

Papillary Lesions of the Breast: Addition of DWI and TIRM Sequences to Routine Breast MRI Could Help in Differentiation Benign from Malignant.
Gültekin MA, Yabul FÇ, Temur HO, Sari L, Yilmaz TF, Toprak H, Yildiz S
Curr Med Imaging 2022;18(9):962-969. doi: 10.2174/1573405618666220218101931. PMID: 35184715
Magnetic resonance imaging in the evaluation of pathologic nipple discharge: indications and imaging findings.
Samreen N, Madsen LB, Chacko C, Heller SL
Br J Radiol 2021 Apr 1;94(1120):20201013. Epub 2021 Feb 5 doi: 10.1259/bjr.20201013. PMID: 33544650Free PMC Article
Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters.
Zhang H, Sun Y, Zhang J, Wang S
Ultrasound Med Biol 2021 Apr;47(4):960-966. Epub 2021 Jan 15 doi: 10.1016/j.ultrasmedbio.2020.12.005. PMID: 33455809
Papillomas of the breast: factors associated with underestimation.
Boufelli G, Giannotti MA, Ruiz CA, Barros N, Chala LF, Maesaka JY, Goncalves R, Bresciani BH, Vianna P, Soares JM Jr, Baracat EC, Filassi JR
Eur J Cancer Prev 2018 Jul;27(4):310-314. doi: 10.1097/CEJ.0000000000000343. PMID: 28296665Free PMC Article
Nipple discharge: current diagnostic and therapeutic approaches.
Sakorafas GH
Cancer Treat Rev 2001 Oct;27(5):275-82. doi: 10.1053/ctrv.2001.0234. PMID: 11871863

Therapy

Post hoc analysis of the PATRICIA randomized trial of the efficacy of human papillomavirus type 16 (HPV-16)/HPV-18 AS04-adjuvanted vaccine against incident and persistent infection with nonvaccine oncogenic HPV types using an alternative multiplex type-specific PCR assay for HPV DNA.
Struyf F, Colau B, Wheeler CM, Naud P, Garland S, Quint W, Chow SN, Salmerón J, Lehtinen M, Del Rosario-Raymundo MR, Paavonen J, Teixeira JC, Germar MJ, Peters K, Skinner SR, Limson G, Castellsagué X, Poppe WA, Ramjattan B, Klein TD, Schwarz TF, Chatterjee A, Tjalma WA, Diaz-Mitoma F, Lewis DJ, Harper DM, Molijn A, van Doorn LJ, David MP, Dubin G; HPV PATRICIA Study Group
Clin Vaccine Immunol 2015 Feb;22(2):235-44. Epub 2014 Dec 24 doi: 10.1128/CVI.00457-14. PMID: 25540273Free PMC Article
Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies: analysis of the control arm of PATRICIA.
Castellsagué X, Naud P, Chow SN, Wheeler CM, Germar MJ, Lehtinen M, Paavonen J, Jaisamrarn U, Garland SM, Salmerón J, Apter D, Kitchener H, Teixeira JC, Skinner SR, Limson G, Szarewski A, Romanowski B, Aoki FY, Schwarz TF, Poppe WA, Bosch FX, de Carvalho NS, Peters K, Tjalma WA, Safaeian M, Raillard A, Descamps D, Struyf F, Dubin G, Rosillon D, Baril L
J Infect Dis 2014 Aug 15;210(4):517-34. Epub 2014 Mar 8 doi: 10.1093/infdis/jiu139. PMID: 24610876Free PMC Article
Safety and effectiveness of microdebrider bronchoscopy for the management of central airway obstruction.
Casal RF, Iribarren J, Eapen G, Ost D, Morice R, Lan C, Cornwell L, Almeida FA, Grosu H, Jimenez CA
Respirology 2013 Aug;18(6):1011-5. doi: 10.1111/resp.12087. PMID: 23520982

Prognosis

Magnetic resonance imaging in the evaluation of pathologic nipple discharge: indications and imaging findings.
Samreen N, Madsen LB, Chacko C, Heller SL
Br J Radiol 2021 Apr 1;94(1120):20201013. Epub 2021 Feb 5 doi: 10.1259/bjr.20201013. PMID: 33544650Free PMC Article
Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters.
Zhang H, Sun Y, Zhang J, Wang S
Ultrasound Med Biol 2021 Apr;47(4):960-966. Epub 2021 Jan 15 doi: 10.1016/j.ultrasmedbio.2020.12.005. PMID: 33455809
Pathology of breast papillary neoplasms: Community hospital experience.
Vdovenko AA
Ann Diagn Pathol 2020 Dec;49:151605. Epub 2020 Sep 6 doi: 10.1016/j.anndiagpath.2020.151605. PMID: 32920473
Papillomas of the breast: factors associated with underestimation.
Boufelli G, Giannotti MA, Ruiz CA, Barros N, Chala LF, Maesaka JY, Goncalves R, Bresciani BH, Vianna P, Soares JM Jr, Baracat EC, Filassi JR
Eur J Cancer Prev 2018 Jul;27(4):310-314. doi: 10.1097/CEJ.0000000000000343. PMID: 28296665Free PMC Article
Solitary breast papilloma: comparison of mammographic, galactographic, and pathologic findings.
Woods ER, Helvie MA, Ikeda DM, Mandell SH, Chapel KL, Adler DD
AJR Am J Roentgenol 1992 Sep;159(3):487-91. doi: 10.2214/ajr.159.3.1503011. PMID: 1503011

Clinical prediction guides

Endocrine Mucin-Producing Sweat Gland Carcinoma: Emerging Evidence of Multicentric Cutaneous Origin and Occasional Concurrence With Analogous Breast Tumors.
Ravi PY, Walsh NM, Archibald C, Pasternak S
Am J Dermatopathol 2022 May 1;44(5):321-326. doi: 10.1097/DAD.0000000000002132. PMID: 35170475
Magnetic resonance imaging in the evaluation of pathologic nipple discharge: indications and imaging findings.
Samreen N, Madsen LB, Chacko C, Heller SL
Br J Radiol 2021 Apr 1;94(1120):20201013. Epub 2021 Feb 5 doi: 10.1259/bjr.20201013. PMID: 33544650Free PMC Article
Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters.
Zhang H, Sun Y, Zhang J, Wang S
Ultrasound Med Biol 2021 Apr;47(4):960-966. Epub 2021 Jan 15 doi: 10.1016/j.ultrasmedbio.2020.12.005. PMID: 33455809
Ultrasound-guided percutaneous microwave ablation of central intraductal papilloma: a prospective pilot study.
Yu J, Wu H, Meng XW, Mu MJ, Dou JP, Ahmed M, Liang P
Int J Hyperthermia 2019;36(1):606-612. doi: 10.1080/02656736.2019.1619849. PMID: 31179781
The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease.
O'Byrne KJ, Dalgleish AG, Browning MJ, Steward WP, Harris AL
Eur J Cancer 2000 Jan;36(2):151-69. doi: 10.1016/s0959-8049(99)00241-5. PMID: 10741273

Recent systematic reviews

Human papillomavirus in breast cancer of patients with cervical intraepithelial neoplasia or cervical cancer history. A systematic review and meta-analysis.
Mareti E, Chatzakis C, Pratilas GC, Liberis A, Vavoulidis E, Papanastasiou A, Dampali R, Daniilidis A, Zepiridis L, Dinas K
J BUON 2021 May-Jun;26(3):707-713. PMID: 34268924
Prevalence of Human Papilloma Virus Sub Genotypes following Head and Neck Squamous Cell Carcinomas in Asian Continent, A Systematic Review Article.
Bukhari N, Joseph JP, Hussain SS, Khan MA, Wakim MJY, Yahya EB, Arif A, Saleem A, Sharif N
Asian Pac J Cancer Prev 2019 Nov 1;20(11):3269-3277. doi: 10.31557/APJCP.2019.20.11.3269. PMID: 31759348Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...