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Cervicomedullary junction neoplasm

MedGen UID:
272453
•Concept ID:
C1332923
•
Neoplastic Process
Synonyms: Cervicomedullary Junction Neoplasm; cervicomedullary junction neoplasm; Cervicomedullary Junction Neoplasms; cervicomedullary junction neoplasms; Cervicomedullary Junction Tumor; cervicomedullary junction tumor; cervicomedullary junction tumour; Neoplasm of Cervicomedullary Junction; neoplasm of cervicomedullary junction; Neoplasm of the Cervicomedullary Junction; neoplasm of the cervicomedullary junction; Tumor of Cervicomedullary Junction; tumor of cervicomedullary junction; Tumor of the Cervicomedullary Junction; tumor of the cervicomedullary junction; tumour of cervicomedullary junction; tumour of the cervicomedullary junction
 
Monarch Initiative: MONDO:0003108

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervicomedullary junction neoplasm

Professional guidelines

PubMed

Intra-axial tumors of the medullocervical junction: diagnosis and microsurgical treatment.
Xu Q, Bao W, Mao R, Pang L
Chin Med J (Engl) 1998 Nov;111(11):968-71. PMID: 11189220

Recent clinical studies

Etiology

Spinal involvement in pediatric familial cavernous malformation syndrome.
Geraldo AF, Luis A, Alves CAPF, Tortora D, Guimarães J, Reimão S, Pavanello M, de Marco P, Scala M, Capra V, Rossi A, Schwartz ES, Mankad K, Severino M
Neuroradiology 2022 Aug;64(8):1671-1679. Epub 2022 Apr 22 doi: 10.1007/s00234-022-02958-1. PMID: 35451625
Outcome Features Analysis in Intramedullary Tumors of the Cervicomedullary Junction: A Surgical Series.
Tariciotti L, Brunetto GMF, Landi A, Gregori F, Santoro F, Frati A, Delfini R, Santoro A
J Neurol Surg A Cent Eur Neurosurg 2021 May;82(3):225-231. Epub 2021 Feb 4 doi: 10.1055/s-0040-1719080. PMID: 33540453
Brain-stem hemangioblastomas: The seemingly innocuous lesion in a perilous location.
Joseph J, Behari S, Gupta S, Bhaisora KS, Gandhi A, Srivastava A, Jaiswal AK
Neurol India 2018 May-Jun;66(3):779-796. doi: 10.4103/0028-3886.232294. PMID: 29766943
Intra-axial tumors of the cervicomedullary junction: surgical results and long-term outcome.
Weiner HL, Freed D, Woo HH, Rezai AR, Kim R, Epstein FJ
Pediatr Neurosurg 1997 Jul;27(1):12-8. doi: 10.1159/000121219. PMID: 9486831
Median labiomandibular glossotomy.
Wessberg GA, Hill SC, McBride KL
Int J Oral Surg 1981 Oct;10(5):333-7. doi: 10.1016/s0300-9785(81)80030-0. PMID: 6807920

Diagnosis

Giant Cell Ependymoma of Cervicomedullary Junction: A Case Report of a Long-Term Survivor and Literature Review.
Cappelletti M, Ruggeri AG, Iacopino G, Delfini R
World Neurosurg 2018 Aug;116:121-126. Epub 2018 May 14 doi: 10.1016/j.wneu.2018.05.040. PMID: 29772366
Ganglioglioma of brain stem and cervicomedullary junction: A 50years review of literature.
Janjua MB, Ivasyk I, Pisapia DJ, Souweidane MM
J Clin Neurosci 2017 Oct;44:34-46. Epub 2017 Jul 4 doi: 10.1016/j.jocn.2017.06.021. PMID: 28687443
Calcifying Pseudoneoplasm of the Cervicomedullary Junction: Case Report and a Literature Review.
Alshareef M, Vargas J, Welsh CT, Kalhorn SP
World Neurosurg 2016 Jan;85:364.e11-8. Epub 2015 Sep 1 doi: 10.1016/j.wneu.2015.08.055. PMID: 26341436
Advances toward an understanding of brainstem gliomas.
Donaldson SS, Laningham F, Fisher PG
J Clin Oncol 2006 Mar 10;24(8):1266-72. doi: 10.1200/JCO.2005.04.6599. PMID: 16525181
MR imaging of the craniovertebral junction.
Smoker WR
Magn Reson Imaging Clin N Am 2000 Aug;8(3):635-50. PMID: 10947931

Therapy

Rhombencephalitis and longitudinal extensive myelitis associated with dinutuximab use in high-risk neuroblastoma.
Atak F, Aydın GB, Öncel İ, Öz S, Oğuz KK
Turk J Pediatr 2023;65(3):523-530. doi: 10.24953/turkjped.2022.598. PMID: 37395971
Brain-stem hemangioblastomas: The seemingly innocuous lesion in a perilous location.
Joseph J, Behari S, Gupta S, Bhaisora KS, Gandhi A, Srivastava A, Jaiswal AK
Neurol India 2018 May-Jun;66(3):779-796. doi: 10.4103/0028-3886.232294. PMID: 29766943
Endoscopic endonasal transclival transodontoid approach for ventral decompression of the craniovertebral junction: operative technique and nuances.
Liu JK, Patel J, Goldstein IM, Eloy JA
Neurosurg Focus 2015 Apr;38(4):E17. doi: 10.3171/2015.1.FOCUS14813. PMID: 25828493
Surgical approaches: postoperative care and complications "posterolateral-far lateral transcondylar approach to the ventral foramen magnum and upper cervical spinal canal".
Menezes AH
Childs Nerv Syst 2008 Oct;24(10):1203-7. Epub 2008 Mar 26 doi: 10.1007/s00381-008-0597-5. PMID: 18365213
Advances toward an understanding of brainstem gliomas.
Donaldson SS, Laningham F, Fisher PG
J Clin Oncol 2006 Mar 10;24(8):1266-72. doi: 10.1200/JCO.2005.04.6599. PMID: 16525181

Prognosis

Myopericytoma at the Craniocervical Junction: Clinicopathological Report and Review of a Rare Perivascular Neoplasm.
Yang JC, Venteicher AS, Koch MJ, Stapleton CJ, Friedman GN, Venteicher EM, Shin JH
Neurosurgery 2019 Aug 1;85(2):E360-E365. doi: 10.1093/neuros/nyy262. PMID: 29889275
Giant Cell Ependymoma of Cervicomedullary Junction: A Case Report of a Long-Term Survivor and Literature Review.
Cappelletti M, Ruggeri AG, Iacopino G, Delfini R
World Neurosurg 2018 Aug;116:121-126. Epub 2018 May 14 doi: 10.1016/j.wneu.2018.05.040. PMID: 29772366
Calcifying Pseudoneoplasm of the Cervicomedullary Junction: Case Report and a Literature Review.
Alshareef M, Vargas J, Welsh CT, Kalhorn SP
World Neurosurg 2016 Jan;85:364.e11-8. Epub 2015 Sep 1 doi: 10.1016/j.wneu.2015.08.055. PMID: 26341436
Advances toward an understanding of brainstem gliomas.
Donaldson SS, Laningham F, Fisher PG
J Clin Oncol 2006 Mar 10;24(8):1266-72. doi: 10.1200/JCO.2005.04.6599. PMID: 16525181
Median labiomandibular glossotomy.
Wessberg GA, Hill SC, McBride KL
Int J Oral Surg 1981 Oct;10(5):333-7. doi: 10.1016/s0300-9785(81)80030-0. PMID: 6807920

Clinical prediction guides

Rhombencephalitis and longitudinal extensive myelitis associated with dinutuximab use in high-risk neuroblastoma.
Atak F, Aydın GB, Öncel İ, Öz S, Oğuz KK
Turk J Pediatr 2023;65(3):523-530. doi: 10.24953/turkjped.2022.598. PMID: 37395971
Progressive motor impairment from "critical" demyelinating lesions of the cervicomedullary junction.
Jackson-Tarlton CS, Flanagan EP, Messina SA, Barakat B, Ahmad R, Kantarci OH, Weinshenker BG, Keegan BM
Mult Scler 2023 Jan;29(1):74-80. Epub 2022 Aug 24 doi: 10.1177/13524585221114438. PMID: 36000479
Spinal involvement in pediatric familial cavernous malformation syndrome.
Geraldo AF, Luis A, Alves CAPF, Tortora D, Guimarães J, Reimão S, Pavanello M, de Marco P, Scala M, Capra V, Rossi A, Schwartz ES, Mankad K, Severino M
Neuroradiology 2022 Aug;64(8):1671-1679. Epub 2022 Apr 22 doi: 10.1007/s00234-022-02958-1. PMID: 35451625
Surgical Management and Functional Outcomes of Cavernous Malformations Involving the Medulla Oblongata.
Xie MG, Xiao XR, Guo FZ, Zhang JT, Wu Z, Zhang LW
World Neurosurg 2018 Nov;119:e643-e652. Epub 2018 Aug 2 doi: 10.1016/j.wneu.2018.07.229. PMID: 30077748
Intra-axial tumors of the cervicomedullary junction: surgical results and long-term outcome.
Weiner HL, Freed D, Woo HH, Rezai AR, Kim R, Epstein FJ
Pediatr Neurosurg 1997 Jul;27(1):12-8. doi: 10.1159/000121219. PMID: 9486831

Recent systematic reviews

A rare condition: Spontaneous subarachnoid haemorrhage due to spinal hemangioblastoma: Report of 2 cases and review of the literature.
Tuleasca C, Knafo S, David P, Richard S, Adam C, Aghakhani N, Parker F
Neurochirurgie 2020 Nov;66(5):359-364. Epub 2020 Aug 28 doi: 10.1016/j.neuchi.2020.05.008. PMID: 32866499

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