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Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation

MedGen UID:
272481
•Concept ID:
C1333040
•
Neoplastic Process

Definition

A chronic lymphocytic leukemia characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Lymphocytic Leukemia with Plasmacytoid Differentiation

Professional guidelines

PubMed

Comparison of Myocyte Enhancer Factor 2B Versus Other Germinal Center-associated Antigens in the Differential Diagnosis of B-Cell Non-Hodgkin Lymphomas.
Moore EM, Swerdlow SH, Gibson SE
Am J Surg Pathol 2018 Mar;42(3):342-350. doi: 10.1097/PAS.0000000000001015. PMID: 29309299
Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.
Liu TY, Chen SU, Kuo SH, Cheng AL, Lin CW
Mod Pathol 2010 Nov;23(11):1507-17. Epub 2010 Aug 27 doi: 10.1038/modpathol.2010.139. PMID: 20802470

Recent clinical studies

Etiology

Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.
Liu TY, Chen SU, Kuo SH, Cheng AL, Lin CW
Mod Pathol 2010 Nov;23(11):1507-17. Epub 2010 Aug 27 doi: 10.1038/modpathol.2010.139. PMID: 20802470
Cytomorphologic spectrum of small lymphocytic lymphoma in patients with an accelerated clinical course.
Shin HJ, Caraway NP, Katz RL
Cancer 2003 Oct 25;99(5):293-300. doi: 10.1002/cncr.11441. PMID: 14579296
CD5 expression in B-cell small lymphocytic malignancies. Correlations with clinical presentation and sites of disease.
Sundeen JT, Longo DL, Jaffe ES
Am J Surg Pathol 1992 Feb;16(2):130-7. doi: 10.1097/00000478-199202000-00005. PMID: 1370753
B-cell neoplasms of the lymphocytic, lymphoplasmacytoid, and plasma cell types: immunohistologic analysis and clinical correlation.
Harris NL, Bhan AK
Hum Pathol 1985 Aug;16(8):829-37. doi: 10.1016/s0046-8177(85)80255-0. PMID: 3926626

Diagnosis

Blastic plasmacytoid dendritic cell neoplasm in the background of myeloproliferative disorder and chronic lymphocytic leukaemia.
Khan AM, Munir A, Raval M, Mehdi S
BMJ Case Rep 2019 Jul 15;12(7) doi: 10.1136/bcr-2019-230332. PMID: 31308179Free PMC Article
Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation: A CARE-compliant article and review of literature.
Ma S, Jug R, Shen S, Zhang WL, Xu HT, Yang LH
Medicine (Baltimore) 2018 Jan;97(2):e9648. doi: 10.1097/MD.0000000000009648. PMID: 29480878Free PMC Article
Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
Diagnostic and clinical considerations in concomitant bone marrow involvement by plasma cell myeloma and chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis: a series of 15 cases and review of literature.
Alley CL, Wang E, Dunphy CH, Gong JZ, Lu CM, Boswell EL, Burchette J, Lagoo AS
Arch Pathol Lab Med 2013 Apr;137(4):503-17. doi: 10.5858/arpa.2011-0696-OA. PMID: 23544940
Regulation of the MIR155 host gene in physiological and pathological processes.
Elton TS, Selemon H, Elton SM, Parinandi NL
Gene 2013 Dec 10;532(1):1-12. Epub 2012 Dec 14 doi: 10.1016/j.gene.2012.12.009. PMID: 23246696

Therapy

Blastic plasmacytoid dendritic cell neoplasm in the background of myeloproliferative disorder and chronic lymphocytic leukaemia.
Khan AM, Munir A, Raval M, Mehdi S
BMJ Case Rep 2019 Jul 15;12(7) doi: 10.1136/bcr-2019-230332. PMID: 31308179Free PMC Article
Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes.
Yin CC, Lin KI, Ketterling RP, Knudson RA, Medeiros LJ, Barron LL, Huh YO, Luthra R, Keating MJ, Abruzzo LV
Am J Clin Pathol 2009 May;131(5):663-70. doi: 10.1309/AJCPXLY46UPFLISC. PMID: 19369625
t(14;18)(q32;q21)-bearing pleural MALT lymphoma with IgM paraproteinemia: value of detection of specific cytogenetic abnormalities in the differential diagnosis of MALT lymphoma and lymphoplasmacytic lymphoma.
Gomyo H, Kajimoto K, Maeda A, Mizuno I, Funada Y, Koizumi T, Fukui E, Hanioka K, Ogura M, Murayama T
Hematology 2007 Aug;12(4):315-8. doi: 10.1080/10245330701383866. PMID: 17654058
Monoclonal gammopathy after low-grade MALT lymphoma: evidence for a second neoplasm.
Pachmann S, Anderegg B, Müller-Höcker J, Nathrath W, Brack N, Tigges FJ, Hartenstein R, Munker R
Am J Hematol 2002 Jun;70(2):167-73. doi: 10.1002/ajh.10104. PMID: 12111792
Beneficial effects of rituximab on primary cold agglutinin disease refractory to conventional therapy.
Mori A, Tamaru J, Sumi H, Kondo H
Eur J Haematol 2002 Apr;68(4):243-6. doi: 10.1034/j.1600-0609.2002.01667.x. PMID: 12071942

Prognosis

Concurrent Diagnosis of Chronic Lymphocytic Leukemia and Plasma Cell Myeloma: Report of 2 Cases and Differential Diagnostic Considerations.
Odujoko O, Bal S, Kansal N, Pathan NF, Gupta G
Am J Case Rep 2024 Oct 5;25:e944707. doi: 10.12659/AJCR.944707. PMID: 39367591Free PMC Article
Blastic plasmacytoid dendritic cell neoplasm in the background of myeloproliferative disorder and chronic lymphocytic leukaemia.
Khan AM, Munir A, Raval M, Mehdi S
BMJ Case Rep 2019 Jul 15;12(7) doi: 10.1136/bcr-2019-230332. PMID: 31308179Free PMC Article
Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
Diagnosis and prognosis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL).
Asaad NY, Abd El-Wahed MM, Dawoud MM
J Egypt Natl Canc Inst 2005 Dec;17(4):279-90. PMID: 17102815
"Well-differentiated" lymphocytic neoplasms. Immunologic findings correlated with clinical presentation and morphologic features.
Medeiros LJ, Strickler JG, Picker LJ, Gelb AB, Weiss LM, Warnke RA
Am J Pathol 1987 Dec;129(3):523-35. PMID: 3322023Free PMC Article

Clinical prediction guides

Concurrent Diagnosis of Chronic Lymphocytic Leukemia and Plasma Cell Myeloma: Report of 2 Cases and Differential Diagnostic Considerations.
Odujoko O, Bal S, Kansal N, Pathan NF, Gupta G
Am J Case Rep 2024 Oct 5;25:e944707. doi: 10.12659/AJCR.944707. PMID: 39367591Free PMC Article
Clinicopathologic features of Waldenstrom's macroglobulinemia and marginal zone lymphoma: are they distinct or the same entity?
Berger F, Traverse-Glehen A, Felman P, Callet-Bauchu E, Baseggio L, Gazzo S, Thieblemont C, Ffrench M, Magaud JP, Salles G, Coiffer B
Clin Lymphoma 2005 Mar;5(4):220-4. doi: 10.3816/clm.2005.n.003. PMID: 15794852
"Well-differentiated" lymphocytic neoplasms. Immunologic findings correlated with clinical presentation and morphologic features.
Medeiros LJ, Strickler JG, Picker LJ, Gelb AB, Weiss LM, Warnke RA
Am J Pathol 1987 Dec;129(3):523-35. PMID: 3322023Free PMC Article
Chronic B-lymphocytic leukemia cells proliferate and differentiate following exposure to interferon in vitro.
Ostlund L, Einhorn S, Robèrt KH, Juliusson G, Biberfeld P
Blood 1986 Jan;67(1):152-9. PMID: 2416366
Phorbol ester-induced differentiation of chronic lymphocytic leukaemia cells.
Tötterman TH, Nilsson K, Sundström C
Nature 1980 Nov 13;288(5787):176-8. doi: 10.1038/288176a0. PMID: 7432517

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