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Squamous cell carcinoma of colon

MedGen UID:
272494
Concept ID:
C1333100
Neoplastic Process
Synonyms: Colon Epidermoid Carcinoma; colon epidermoid carcinoma; colon squamous cell cancer; Colon Squamous Cell Carcinoma; colon squamous cell carcinoma; Colonic Epidermoid Carcinoma; colonic epidermoid carcinoma; Colonic Squamous Cell Carcinoma; colonic squamous cell carcinoma; Epidermoid Carcinoma of Colon; epidermoid carcinoma of colon; Epidermoid Carcinoma of the Colon; epidermoid carcinoma of the colon; Squamous Cell Carcinoma of Colon; squamous cell carcinoma of colon; Squamous Cell Carcinoma of the Colon; squamous cell carcinoma of the colon; Squamous cell carcinoma of the colon; Squamous Cell Colon Carcinoma; squamous cell colon carcinoma
SNOMED CT: Squamous cell carcinoma of colon (766981007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018513
Orphanet: ORPHA423994

Definition

A rare epithelial tumour of the colon arising from squamous cells of the colorectal epithelium without the presence of squamous-lined fistulous tracts or a proximal extension of an anal squamous cell carcinoma. It usually presents with nonspecific symptoms, such as anorexia, weight loss, abdominal pain, changes of bowel habits, hematochesia or melena. Cases of severe, symptomatic hypercalcemia have been reported. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell carcinoma of colon

Professional guidelines

PubMed

Mat Lazim N, Elliott M, Wykes J, Clark J
ANZ J Surg 2021 Dec;91(12):2617-2623. Epub 2021 Feb 26 doi: 10.1111/ans.16622. PMID: 33634950
Gardner IH, Watson KM
Dis Colon Rectum 2020 Oct;63(10):1358-1361. doi: 10.1097/DCR.0000000000001791. PMID: 32969877
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Recent clinical studies

Etiology

Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Motallebi M, Bhia M, Rajani HF, Bhia I, Tabarraei H, Mohammadkhani N, Pereira-Silva M, Kasaii MS, Nouri-Majd S, Mueller AL, Veiga FJB, Paiva-Santos AC, Shakibaei M
Life Sci 2022 Sep 15;305:120752. Epub 2022 Jun 29 doi: 10.1016/j.lfs.2022.120752. PMID: 35779626
Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599

Diagnosis

Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Eng C, Ciombor KK, Cho M, Dorth JA, Rajdev LN, Horowitz DP, Gollub MJ, Jácome AA, Lockney NA, Muldoon RL, Washington MK, O'Brian BA, Benny A, Lebeck Lee CM, Benson AB 3rd, Goodman KA, Morris VK
J Clin Oncol 2022 Aug 20;40(24):2774-2788. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02566. PMID: 35649196
Stasiewicz M, Karpiński TM
Semin Cancer Biol 2022 Nov;86(Pt 3):633-642. Epub 2021 Nov 4 doi: 10.1016/j.semcancer.2021.11.002. PMID: 34743032
Gardner IH, Watson KM
Dis Colon Rectum 2020 Oct;63(10):1358-1361. doi: 10.1097/DCR.0000000000001791. PMID: 32969877
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599

Therapy

Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Motallebi M, Bhia M, Rajani HF, Bhia I, Tabarraei H, Mohammadkhani N, Pereira-Silva M, Kasaii MS, Nouri-Majd S, Mueller AL, Veiga FJB, Paiva-Santos AC, Shakibaei M
Life Sci 2022 Sep 15;305:120752. Epub 2022 Jun 29 doi: 10.1016/j.lfs.2022.120752. PMID: 35779626
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Ruan S, Lin M, Zhu Y, Lum L, Thakur A, Jin R, Shao W, Zhang Y, Hu Y, Huang S, Hurt EM, Chang AE, Wicha MS, Li Q
Cancer Res 2020 Feb 15;80(4):771-783. Epub 2019 Dec 16 doi: 10.1158/0008-5472.CAN-19-1145. PMID: 31843981Free PMC Article

Prognosis

Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Jiang L, Zhu J
Curr Protein Pept Sci 2020;21(11):1044-1053. doi: 10.2174/1389203721666200210102751. PMID: 32039677
Künzel J, Gribko A, Lu Q, Stauber RH, Wünsch D
Biol Chem 2019 Oct 25;400(11):1465-1479. doi: 10.1515/hsz-2019-0141. PMID: 30903749
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Clinical prediction guides

Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article

Recent systematic reviews

Detopoulou P, Panoutsopoulos GI, Mantoglou M, Michailidis P, Pantazi I, Papadopoulos S, Rojas Gil AP
Curr Oncol 2023 Mar 14;30(3):3391-3420. doi: 10.3390/curroncol30030258. PMID: 36975471Free PMC Article
Singh D, Gupta M, Sarwat M, Siddique HR
Crit Rev Oncol Hematol 2022 Aug;176:103751. Epub 2022 Jun 22 doi: 10.1016/j.critrevonc.2022.103751. PMID: 35752426
Piovani D, Hassan C, Repici A, Rimassa L, Carlo-Stella C, Nikolopoulos GK, Riboli E, Bonovas S
Gastroenterology 2022 Sep;163(3):671-684. Epub 2022 May 26 doi: 10.1053/j.gastro.2022.05.038. PMID: 35643170
Schizas D, Katsaros I, Mastoraki A, Karela NR, Zampetaki D, Lazaridis II, Tsapralis D, Theodoropoulos GE
J Invest Surg 2022 Jan;35(1):151-156. Epub 2020 Oct 6 doi: 10.1080/08941939.2020.1824044. PMID: 33021125
Gandini S, Gnagnarella P, Serrano D, Pasquali E, Raimondi S
Adv Exp Med Biol 2014;810:69-105. doi: 10.1007/978-1-4939-0437-2_5. PMID: 25207361

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