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Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

MedGen UID:
272544
•Concept ID:
C1333293
•
Neoplastic Process
Synonym: Diffuse Large B-Cell Lymphoma PTLD

Definition

A diffuse large B-cell lymphoma that arises in a patient with a history of organ transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086

Recent clinical studies

Etiology

B Cell Lymphomas of the GI Tract.
Small S, Barnea Slonim L, Williams C, Karmali R
Curr Gastroenterol Rep 2021 May 8;23(7):9. doi: 10.1007/s11894-021-00811-8. PMID: 33963950
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Is It Time to Revisit the Role of Allogeneic Transplantation in Lymphoma?
Shanbhag S, Wagner-Johnston N, Ambinder RF, Jones RJ
Curr Oncol Rep 2019 Jun 10;21(7):65. doi: 10.1007/s11912-019-0809-z. PMID: 31183579
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-autologous transplant maintenance therapies in lymphoma: current state and future directions.
Riedell PA, Bishop MR
Bone Marrow Transplant 2018 Jan;53(1):11-21. Epub 2017 Oct 2 doi: 10.1038/bmt.2017.196. PMID: 28967896

Diagnosis

Plasmablastic Lymphoma: Past, Present, and Future.
Kaur S, Kollimuttathuillam S
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):e253-e259. Epub 2023 Jun 14 doi: 10.1016/j.clml.2023.05.014. PMID: 37453866
B Cell Lymphomas of the GI Tract.
Small S, Barnea Slonim L, Williams C, Karmali R
Curr Gastroenterol Rep 2021 May 8;23(7):9. doi: 10.1007/s11894-021-00811-8. PMID: 33963950
Update on B-cell lymphoproliferative disorders of the gastrointestinal tract.
Plummer RM, Linden MA, Beckman AK
Semin Diagn Pathol 2021 Jul;38(4):14-20. Epub 2021 Mar 26 doi: 10.1053/j.semdp.2021.03.006. PMID: 33863577
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Diagnostic, prognostic and therapeutic role of CD30 in lymphoma.
Pierce JM, Mehta A
Expert Rev Hematol 2017 Jan;10(1):29-37. Epub 2016 Dec 21 doi: 10.1080/17474086.2017.1270202. PMID: 27927047

Therapy

Prior antithymocyte globulin therapy and survival in post-transplant lymphoproliferative disorders.
Kinch A, Baecklund E, Molin D, Pauksens K, Sundström C, Tufveson G, Enblad G
Acta Oncol 2021 Jun;60(6):771-778. Epub 2021 Apr 1 doi: 10.1080/0284186X.2021.1904520. PMID: 33793378
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Diagnostic, prognostic and therapeutic role of CD30 in lymphoma.
Pierce JM, Mehta A
Expert Rev Hematol 2017 Jan;10(1):29-37. Epub 2016 Dec 21 doi: 10.1080/17474086.2017.1270202. PMID: 27927047
Hepatitis C virus - associated B cell non-Hodgkin's lymphoma.
Mihăilă RG
World J Gastroenterol 2016 Jul 21;22(27):6214-23. doi: 10.3748/wjg.v22.i27.6214. PMID: 27468211Free PMC Article

Prognosis

Plasmablastic Lymphoma: Past, Present, and Future.
Kaur S, Kollimuttathuillam S
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):e253-e259. Epub 2023 Jun 14 doi: 10.1016/j.clml.2023.05.014. PMID: 37453866
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Failure of rituximab is associated with a poor outcome in diffuse large B cell lymphoma-type post-transplant lymphoproliferative disorder.
Jain MD, Lam R, Liu Z, Stubbins RJ, Kahlon A, Kansara R, Goswami R, Humar A, Prica A, Sehn LH, Slack GW, Crump M, Savage KJ, Peters AC, Kuruvilla J
Br J Haematol 2020 Apr;189(1):97-105. Epub 2020 Feb 18 doi: 10.1111/bjh.16304. PMID: 32068243
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Diagnostic, prognostic and therapeutic role of CD30 in lymphoma.
Pierce JM, Mehta A
Expert Rev Hematol 2017 Jan;10(1):29-37. Epub 2016 Dec 21 doi: 10.1080/17474086.2017.1270202. PMID: 27927047

Clinical prediction guides

Phenogenomic heterogeneity of post-transplant plasmablastic lymphomas.
Leeman-Neill RJ, Soderquist CR, Montanari F, Raciti P, Park D, Radeski D, Mansukhani MM, Murty VV, Hsiao S, Alobeid B, Bhagat G
Haematologica 2022 Jan 1;107(1):201-210. doi: 10.3324/haematol.2020.267294. [Epub ahead of print] PMID: 33297669Free PMC Article
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Defective Epstein-Barr virus in chronic active infection and haematological malignancy.
Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H
Nat Microbiol 2019 Mar;4(3):404-413. Epub 2019 Jan 21 doi: 10.1038/s41564-018-0334-0. PMID: 30664667
Mutational landscape of B-cell post-transplant lymphoproliferative disorders.
Menter T, Juskevicius D, Alikian M, Steiger J, Dirnhofer S, Tzankov A, Naresh KN
Br J Haematol 2017 Jul;178(1):48-56. Epub 2017 Apr 17 doi: 10.1111/bjh.14633. PMID: 28419429
Hepatitis C virus - associated B cell non-Hodgkin's lymphoma.
Mihăilă RG
World J Gastroenterol 2016 Jul 21;22(27):6214-23. doi: 10.3748/wjg.v22.i27.6214. PMID: 27468211Free PMC Article

Recent systematic reviews

CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review.
Portuguese AJ, Gauthier J, Tykodi SS, Hall ET, Hirayama AV, Yeung CCS, Blosser CD
Bone Marrow Transplant 2023 Apr;58(4):353-359. Epub 2022 Dec 27 doi: 10.1038/s41409-022-01907-z. PMID: 36575360
Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review.
Berger GK, McBride A, Lawson S, Royball K, Yun S, Gee K, Bin Riaz I, Saleh AA, Puvvada S, Anwer F
Crit Rev Oncol Hematol 2017 Jan;109:42-50. Epub 2016 Nov 21 doi: 10.1016/j.critrevonc.2016.11.009. PMID: 28010897Free PMC Article

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