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Diffuse lipomatosis

MedGen UID:
272546
•Concept ID:
C1333298
•
Neoplastic Process
Synonyms: Diffuse Lipomatosis; diffuse lipomatosis
 
Monarch Initiative: MONDO:0006539

Definition

A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue. It has been associated with several genetic disorders and different clinical conditions such as liver disease, excessive alcohol intake, adrenocortical steroid therapy, and antiretroviral therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse lipomatosis

Professional guidelines

PubMed

Review of Dercum's disease and proposal of diagnostic criteria, diagnostic methods, classification and management.
Hansson E, Svensson H, Brorson H
Orphanet J Rare Dis 2012 Apr 30;7:23. doi: 10.1186/1750-1172-7-23. PMID: 22546240Free PMC Article
Unusual distribution of the lower body fatty tissue: classification, treatment, and differential diagnosis.
El-Khatib HA
Ann Plast Surg 2008 Jul;61(1):2-8. doi: 10.1097/SAP.0b013e318156debe. PMID: 18580141

Recent clinical studies

Etiology

Navigating the complexities of encephalocraniocutaneous lipomatosis: a case series and review.
Pavanello M, Piro L, Roggero A, Rossi A, Cataldi M, Piatelli G
Childs Nerv Syst 2024 Apr;40(4):1251-1258. Epub 2024 Jan 13 doi: 10.1007/s00381-024-06279-x. PMID: 38217730Free PMC Article
Fat-containing salivary gland tumors: a review.
Agaimy A
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S90-6. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0459-7. PMID: 23821211Free PMC Article
Giant nevi: a review.
Chung C, Forte AJ, Narayan D, Persing J
J Craniofac Surg 2006 Nov;17(6):1210-5. doi: 10.1097/01.scs.0000231619.95263.a2. PMID: 17119398
Lipomatous lesions of the parotid gland.
Ethunandan M, Vura G, Umar T, Anand R, Pratt CA, Macpherson DW, Wilson AW
J Oral Maxillofac Surg 2006 Nov;64(11):1583-6. doi: 10.1016/j.joms.2005.10.059. PMID: 17052582
Epidural, paraspinal, and subcutaneous lipomatosis.
Sener RN
Pediatr Radiol 2003 Sep;33(9):655-7. Epub 2003 Jul 8 doi: 10.1007/s00247-003-0977-7. PMID: 12851798

Diagnosis

Navigating the complexities of encephalocraniocutaneous lipomatosis: a case series and review.
Pavanello M, Piro L, Roggero A, Rossi A, Cataldi M, Piatelli G
Childs Nerv Syst 2024 Apr;40(4):1251-1258. Epub 2024 Jan 13 doi: 10.1007/s00381-024-06279-x. PMID: 38217730Free PMC Article
A 54-Year-Old Woman with Papillary Thyroid Carcinoma Associated with Secondary Amyloid Goiter and Thyroid Lipomatosis.
Morado da Silva EM, Ferreira RADC, Lozada ARC, Duarte JMS
Am J Case Rep 2022 Dec 28;23:e938156. doi: 10.12659/AJCR.938156. PMID: 36575639Free PMC Article
Fat-containing salivary gland tumors: a review.
Agaimy A
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S90-6. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0459-7. PMID: 23821211Free PMC Article
Diffuse lipomatosis of the thyroid with amyloid deposition.
Jacques TA, Stearns MP
J Laryngol Otol 2013 Apr;127(4):426-8. Epub 2013 Jan 23 doi: 10.1017/S0022215112003209. PMID: 23339824
Diffuse lipomatosis of thyroid gland.
Arslan A, Alíç B, Uzunlar AK, Büyükbayram H, Sarí I
Auris Nasus Larynx 1999 Apr;26(2):213-5. doi: 10.1016/s0385-8146(98)00049-2. PMID: 10214903

Therapy

A 54-Year-Old Woman with Papillary Thyroid Carcinoma Associated with Secondary Amyloid Goiter and Thyroid Lipomatosis.
Morado da Silva EM, Ferreira RADC, Lozada ARC, Duarte JMS
Am J Case Rep 2022 Dec 28;23:e938156. doi: 10.12659/AJCR.938156. PMID: 36575639Free PMC Article
Lipomatosis of spinal epidural space, peritoneum, and renal sinus: a rare complication of long-term steroid therapy in a child with nephrotic syndrome.
Dawman L, Bhattacharya D, Sharawat IK, Indla RT, Bhatia A, Tiewsoh K
Childs Nerv Syst 2019 Aug;35(8):1401-1405. Epub 2019 Apr 2 doi: 10.1007/s00381-019-04141-z. PMID: 30941508
Diffuse lipomatosis of thyroid with hyperthyroidism.
Pradeep PV, Kumar R, Ragavan M, Ramakrishna BA
J Postgrad Med 2010 Jan-Mar;56(1):35-6. doi: 10.4103/0022-3859.62430. PMID: 20393249
Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature.
Ge Y, Luna MA, Cowan DF, Truong LD, Ayala AG
Ann Diagn Pathol 2009 Dec;13(6):384-9. doi: 10.1016/j.anndiagpath.2009.08.003. PMID: 19917474
Lipomatous lesions of the parotid gland.
Ethunandan M, Vura G, Umar T, Anand R, Pratt CA, Macpherson DW, Wilson AW
J Oral Maxillofac Surg 2006 Nov;64(11):1583-6. doi: 10.1016/j.joms.2005.10.059. PMID: 17052582

Prognosis

Recurrent diffuse lipomatosis of the neck--a case report.
Punia RS, Nanda A, Bakshi A, Mohan H, Gupta S
Indian J Pathol Microbiol 2004 Jan;47(1):41-2. PMID: 15471125
Bannayan syndrome--generalized lipomatosis associated with megalencephaly and macrodactyly.
Okumura K, Sasaki Y, Ohyama M, Nishi T
Acta Pathol Jpn 1986 Feb;36(2):269-77. doi: 10.1111/j.1440-1827.1986.tb01479.x. PMID: 3705960

Clinical prediction guides

Madelung's disease associated with polyneuropathy and symptomatic hypokalemia.
Chan HF, Sun Y, Lin CH, Chen RC
J Formos Med Assoc 2013 May;112(5):283-6. Epub 2013 Apr 24 doi: 10.1016/j.jfma.2012.07.019. PMID: 23623508

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