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Embryonal carcinoma of the central nervous system

MedGen UID:
272566
Concept ID:
C1333377
Neoplastic Process
Synonyms: Central Nervous System Embryonal Carcinoma; central nervous system embryonal carcinoma; embryonal carcinoma; Embryonal Carcinoma of CNS; embryonal carcinoma of CNS; Embryonal Carcinoma of the Central Nervous System; embryonal carcinoma of the central nervous system; Embryonal carcinoma of the CNS; embryonal carcinoma of the CNS
 
Monarch Initiative: MONDO:0018843
Orphanet: ORPHA48736

Definition

A malignant germ cell tumor of the central nervous system composed of large cells that proliferate in cohesive nests and sheets. In rare occasions, tumor cells may replicate the structure of the early embryo, forming ""embryoid bodies"" replete with germ discs and miniature amniotic cavities. Additional morphologic characteristics include enlarged nucleoli, abundant clear to somewhat violet-hued cytoplasm, a high mitotic rate and zones of coagulative necrosis. (Adapted from WHO) [from NCI]

Professional guidelines

PubMed

Rodriguez A, Kamiya-Matsuoka C, Majd NK
Curr Oncol 2023 May 25;30(6):5279-5298. doi: 10.3390/curroncol30060401. PMID: 37366884Free PMC Article
Fujimaki T
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Brandes AA, Pasetto LM, Monfardini S
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Recent clinical studies

Etiology

Saunders J, Ingley K, Wang XQ, Harvey M, Armstrong L, Ng T, Dunham C, Bush J
Pediatr Dev Pathol 2020 Mar-Apr;23(2):132-138. Epub 2019 Aug 12 doi: 10.1177/1093526619869154. PMID: 31403913
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Eberhart CG
Brain Pathol 2011 Jan;21(1):96-104. doi: 10.1111/j.1750-3639.2010.00455.x. PMID: 21129063Free PMC Article
Basile U, Cavallaro G, Polistena A, Giustini S, Orlando G, Cotesta D, Petramala L, Letizia C, Calvieri S, De Toma G
J Gastrointest Surg 2010 Jan;14(1):186-94. doi: 10.1007/s11605-009-0940-5. PMID: 19495890
Bonnin JM, Rubinstein LJ
J Neurosurg 1984 Jun;60(6):1121-33. doi: 10.3171/jns.1984.60.6.1121. PMID: 6202856

Diagnosis

Vasiljevic A, Szathmari A, Champier J, Fèvre-Montange M, Jouvet A
Neurochirurgie 2015 Apr-Jun;61(2-3):130-7. Epub 2014 Apr 13 doi: 10.1016/j.neuchi.2013.06.006. PMID: 24726316
Basile U, Cavallaro G, Polistena A, Giustini S, Orlando G, Cotesta D, Petramala L, Letizia C, Calvieri S, De Toma G
J Gastrointest Surg 2010 Jan;14(1):186-94. doi: 10.1007/s11605-009-0940-5. PMID: 19495890
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Scheithauer BW, Bruner JM
Clin Lab Med 1987 Mar;7(1):157-79. PMID: 3030612
Bonnin JM, Rubinstein LJ
J Neurosurg 1984 Jun;60(6):1121-33. doi: 10.3171/jns.1984.60.6.1121. PMID: 6202856

Therapy

Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571
Newman MB, Misiuta I, Willing AE, Zigova T, Karl RC, Borlongan CV, Sanberg PR
Stem Cells Dev 2005 Feb;14(1):29-43. doi: 10.1089/scd.2005.14.29. PMID: 15725742
Ushio Y, Kochi M, Kuratsu J, Itoyama Y, Marubayashi T
J Neurosurg 1999 Jan;90(1):133-7. doi: 10.3171/jns.1999.90.1.0133. PMID: 10413166
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765
Daugaard G, Rørth M, von der Maase H, Skakkebaek NE
Ann Oncol 1992 Apr;3(4):283-9. doi: 10.1093/oxfordjournals.annonc.a058180. PMID: 1327076

Prognosis

Zilocchi M, Rahmatbakhsh M, Moutaoufik MT, Broderick K, Gagarinova A, Jessulat M, Phanse S, Aoki H, Aly KA, Babu M
Nat Protoc 2023 Dec;18(12):3918-3973. Epub 2023 Nov 20 doi: 10.1038/s41596-023-00901-z. PMID: 37985878
Shipko AF, Fedorenko ZP, Ryzhov AY
Exp Oncol 2022 Dec;44(4):314-319. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-4.19109. PMID: 36811535
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Saunders J, Ingley K, Wang XQ, Harvey M, Armstrong L, Ng T, Dunham C, Bush J
Pediatr Dev Pathol 2020 Mar-Apr;23(2):132-138. Epub 2019 Aug 12 doi: 10.1177/1093526619869154. PMID: 31403913
Pession A, Tonelli R
Curr Cancer Drug Targets 2005 Jun;5(4):273-83. doi: 10.2174/1568009054064606. PMID: 15975048

Clinical prediction guides

Zilocchi M, Rahmatbakhsh M, Moutaoufik MT, Broderick K, Gagarinova A, Jessulat M, Phanse S, Aoki H, Aly KA, Babu M
Nat Protoc 2023 Dec;18(12):3918-3973. Epub 2023 Nov 20 doi: 10.1038/s41596-023-00901-z. PMID: 37985878
Shipko AF, Fedorenko ZP, Ryzhov AY
Exp Oncol 2022 Dec;44(4):314-319. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-4.19109. PMID: 36811535
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Hirato J, Nakazato Y
J Neurooncol 2001 Sep;54(3):239-49. doi: 10.1023/a:1012721723387. PMID: 11767290

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