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Epidermolytic acanthoma

MedGen UID:
272577
•Concept ID:
C1333414
•
Neoplastic Process
Synonyms: Epidermolytic Acanthoma; epidermolytic acanthoma
SNOMED CT: Epidermolytic acanthoma (733892008)
 
Monarch Initiative: MONDO:0002962

Definition

A benign epithelial verrucous lesion of the skin. Morphologically, it is characterized by the presence of epidermolytic hyperkeratosis and papillomatosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Epidermolytic acanthoma

Recent clinical studies

Etiology

Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity.
Argyris PP, Slama ZM, Nelson AC, Koutlas IG
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Dec;128(6):e208-e213. Epub 2019 Mar 31 doi: 10.1016/j.oooo.2019.03.016. PMID: 31078506
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases.
Roy SF, Ghazawi FM, Choate KA, McNiff JM
J Cutan Pathol 2019 May;46(5):305-309. Epub 2019 Feb 8 doi: 10.1111/cup.13422. PMID: 30663082
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases.
Lee TJ, Wu YH
Int J Dermatol 2018 Jan;57(1):28-33. Epub 2017 Oct 31 doi: 10.1111/ijd.13818. PMID: 29090469
Solitary epidermolytic acanthoma.
Kazlouskaya V, Lambe J, Elston D
J Cutan Pathol 2013 Aug;40(8):701-7. Epub 2013 May 24 doi: 10.1111/cup.12165. PMID: 23710687
Solitary epidermolytic acanthoma: a clinical and histopathological study.
Abbas O, Wieland CN, Goldberg LJ
J Eur Acad Dermatol Venereol 2011 Feb;25(2):175-80. Epub 2010 Jun 9 doi: 10.1111/j.1468-3083.2010.03736.x. PMID: 20553361

Diagnosis

Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region.
Chan MP
Arch Pathol Lab Med 2019 Jul;143(7):821-831. Epub 2018 Sep 11 doi: 10.5858/arpa.2018-0039-RA. PMID: 30203987
Solitary epidermolytic acanthoma: a clinical and histopathological study.
Abbas O, Wieland CN, Goldberg LJ
J Eur Acad Dermatol Venereol 2011 Feb;25(2):175-80. Epub 2010 Jun 9 doi: 10.1111/j.1468-3083.2010.03736.x. PMID: 20553361
Porokeratoma.
Walsh SN, Hurt MA, Santa Cruz DJ
Am J Surg Pathol 2007 Dec;31(12):1897-901. doi: 10.1097/PAS.0b013e31806910c7. PMID: 18043046
Acantholytic acanthoma.
Brownstein MH
J Am Acad Dermatol 1988 Nov;19(5 Pt 1):783-6. doi: 10.1016/s0190-9622(88)70234-0. PMID: 2461398
The benign acanthomas.
Brownstein MH
J Cutan Pathol 1985 Jun-Aug;12(3-4):172-88. doi: 10.1111/j.1600-0560.1985.tb01620.x. PMID: 3160731

Therapy

Anogenital epidermolytic acanthomas: effective treatment of pruritus with 0.1% tacrolimus ointment.
Tan GF, Tan ES, Tey HL
Dermatol Ther 2014 Mar-Apr;27(2):113-6. Epub 2013 Jun 6 doi: 10.1111/dth.12068. PMID: 24703270
Disseminated epidermolytic acanthoma revealed by PUVA.
Nakagawa T, Nishimoto M, Takaiwa T
Dermatologica 1986;173(3):150-3. doi: 10.1159/000249239. PMID: 3770261

Prognosis

Multiple localized epidermolytic acanthomas of the vulva associated with vulvar pruritus: a case report.
Hijazi MM, Succaria F, Ghosn S
Am J Dermatopathol 2015 Apr;37(4):e49-52. doi: 10.1097/DAD.0000000000000101. PMID: 25051105
Solitary epidermolytic acanthoma.
Kazlouskaya V, Lambe J, Elston D
J Cutan Pathol 2013 Aug;40(8):701-7. Epub 2013 May 24 doi: 10.1111/cup.12165. PMID: 23710687
Multiple spreading epidermolytic acanthomas of the genital and perigenital skin.
Reguiaï Z, Cribier B, Derancourt C, Perceau G, Bernard P
Dermatology 2005;211(2):152-4. doi: 10.1159/000086447. PMID: 16088164
Verruciform xanthoma in close association with isolated epidermolytic acanthoma: a case report and review of the Japanese dermatological literature.
Fukuda H, Saito R
J Dermatol 2005 Jun;32(6):464-8. doi: 10.1111/j.1346-8138.2005.tb00781.x. PMID: 16043921

Clinical prediction guides

Pilomatrical Acanthoma: An Extremely Rare Intraepidermal Variant of Pilomatricoma.
He L, Hosler GA
Am J Dermatopathol 2022 Jun 1;44(6):433-436. Epub 2022 Feb 2 doi: 10.1097/DAD.0000000000002147. PMID: 35120037
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity.
Argyris PP, Slama ZM, Nelson AC, Koutlas IG
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Dec;128(6):e208-e213. Epub 2019 Mar 31 doi: 10.1016/j.oooo.2019.03.016. PMID: 31078506
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases.
Lee TJ, Wu YH
Int J Dermatol 2018 Jan;57(1):28-33. Epub 2017 Oct 31 doi: 10.1111/ijd.13818. PMID: 29090469
Multiple localized epidermolytic acanthomas of the vulva associated with vulvar pruritus: a case report.
Hijazi MM, Succaria F, Ghosn S
Am J Dermatopathol 2015 Apr;37(4):e49-52. doi: 10.1097/DAD.0000000000000101. PMID: 25051105
Solitary epidermolytic acanthoma: a clinical and histopathological study.
Abbas O, Wieland CN, Goldberg LJ
J Eur Acad Dermatol Venereol 2011 Feb;25(2):175-80. Epub 2010 Jun 9 doi: 10.1111/j.1468-3083.2010.03736.x. PMID: 20553361

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