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Esophageal melanoma

MedGen UID:
272590
•Concept ID:
C1333460
•
Neoplastic Process
Synonyms: Esophageal Melanoma; esophageal melanoma; Esophagus Melanoma; esophagus melanoma; esophagus melanoma (disease); melanoma (disease) of esophagus; melanoma (disease) of oesophagus; Melanoma of Esophagus; melanoma of esophagus; melanoma of oesophagus; Melanoma of the Esophagus; melanoma of the esophagus; melanoma of the oesophagus; mucosal melanoma of the esophagus; mucosal melanoma of the oesophagus; oesophagus melanoma; oesophagus melanoma (disease)
 
Monarch Initiative: MONDO:0001192

Definition

A melanoma affecting the esophageal wall. Melanoma in the esophagus is more commonly metastatic than primary. Primary melanomas of the esophagus are polypoid and clinically aggressive. (WHO, 2000) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal melanoma

Professional guidelines

PubMed

Primary Esophageal Malignant Melanoma in Korea: Clinical features, Management and Prognosis.
Oh HH, Jung YW, Han B, Im CM, Yu HJ, Joo YE
Korean J Gastroenterol 2022 May 25;79(5):222-227. doi: 10.4166/kjg.2022.031. PMID: 35610553
Patterns of care and survival outcomes in the treatment of esophageal melanoma.
Weiner JP, Shao M, Schwartz D, Wong A, Schreiber D
Dis Esophagus 2017 Feb 1;30(2):1-6. doi: 10.1111/dote.12504. PMID: 27862623

Recent clinical studies

Etiology

Endoscopic diagnosis of gastrointestinal melanoma.
Wang S, Sun S, Liu X, Ge N, Wang G, Guo J, Liu W, Hu J
Scand J Gastroenterol 2020 Mar;55(3):330-337. Epub 2020 Mar 19 doi: 10.1080/00365521.2020.1734074. PMID: 32191553
Clinicopathological presentations and surgical outcomes of esophageal melanoma.
Urabe M, Haruta S, Ohkura Y, Inoshita N, Yago A, Koga S, Tanaka T, Ueno M, Udagawa H
Asian Cardiovasc Thorac Ann 2019 Sep;27(7):548-553. Epub 2019 Jul 18 doi: 10.1177/0218492319866064. PMID: 31319672
Patterns of care and survival outcomes in the treatment of esophageal melanoma.
Weiner JP, Shao M, Schwartz D, Wong A, Schreiber D
Dis Esophagus 2017 Feb 1;30(2):1-6. doi: 10.1111/dote.12504. PMID: 27862623
Endoscopic and pathologic findings associated with clinical outcomes of melanoma in the upper gastrointestinal tract.
Ahn JY, Hwang HS, Park YS, Kim HR, Jung HY, Kim JH, Lee SE, Kim MA
Ann Surg Oncol 2014 Aug;21(8):2532-9. Epub 2014 Mar 17 doi: 10.1245/s10434-014-3637-2. PMID: 24633670
Unusual malignant neoplasms of the esophagus. Oat cell carcinoma, melanoma, and sarcoma.
Caldwell CB, Bains MS, Burt M
J Thorac Cardiovasc Surg 1991 Jan;101(1):100-7. PMID: 1702494

Diagnosis

Primary Malignant Melanoma of the Gastroesophageal Junction Treated With Immunotherapy: A Case Report.
Attlassy N, Agbeh A, Patnaik R, Miller J, McCarthy J
WMJ 2023 Mar;122(1):77-80. PMID: 36940130
Primary Esophageal Malignant Melanoma in Korea: Clinical features, Management and Prognosis.
Oh HH, Jung YW, Han B, Im CM, Yu HJ, Joo YE
Korean J Gastroenterol 2022 May 25;79(5):222-227. doi: 10.4166/kjg.2022.031. PMID: 35610553
Endoscopic diagnosis of gastrointestinal melanoma.
Wang S, Sun S, Liu X, Ge N, Wang G, Guo J, Liu W, Hu J
Scand J Gastroenterol 2020 Mar;55(3):330-337. Epub 2020 Mar 19 doi: 10.1080/00365521.2020.1734074. PMID: 32191553
Patterns of care and survival outcomes in the treatment of esophageal melanoma.
Weiner JP, Shao M, Schwartz D, Wong A, Schreiber D
Dis Esophagus 2017 Feb 1;30(2):1-6. doi: 10.1111/dote.12504. PMID: 27862623
Esophageal melanocytosis morphologic features and review of the literature.
Chang F, Deere H
Arch Pathol Lab Med 2006 Apr;130(4):552-7. doi: 10.5858/2006-130-552-EMMFAR. PMID: 16594751

Therapy

Primary Esophageal Malignant Melanoma in Korea: Clinical features, Management and Prognosis.
Oh HH, Jung YW, Han B, Im CM, Yu HJ, Joo YE
Korean J Gastroenterol 2022 May 25;79(5):222-227. doi: 10.4166/kjg.2022.031. PMID: 35610553
Clinicopathological presentations and surgical outcomes of esophageal melanoma.
Urabe M, Haruta S, Ohkura Y, Inoshita N, Yago A, Koga S, Tanaka T, Ueno M, Udagawa H
Asian Cardiovasc Thorac Ann 2019 Sep;27(7):548-553. Epub 2019 Jul 18 doi: 10.1177/0218492319866064. PMID: 31319672
Rapid and clinically significant response to masitinib in the treatment of mucosal primary esophageal melanoma with somatic KIT exon 11 mutation involving brain metastases: A case report.
Prosvicova J, Lukesova S, Kopecky J, Grim J, Papik Z, Kolarova R, Navratilova B, Dubreuil P, Agopian J, Mansfield C, Moussy A, Hermine O
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Dec;159(4):695-7. Epub 2015 Nov 27 doi: 10.5507/bp.2015.061. PMID: 26725706
Primary malignant esophageal melanoma arising from localized benign melanocytosis.
Maroy B, Baylac F
Clin Res Hepatol Gastroenterol 2013 Apr;37(2):e65-7. Epub 2012 Sep 7 doi: 10.1016/j.clinre.2012.08.003. PMID: 22959400
Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin, in resistant solid tumor malignancies.
Fracasso PM, Picus J, Wildi JD, Goodner SA, Creekmore AN, Gao F, Govindan R, Ellis MJ, Tan BR, Linette GP, Fu CJ, Pentikis HS, Zumbrun SC, Egorin MJ, Bellet RE
Cancer Chemother Pharmacol 2009 Feb;63(3):451-8. Epub 2008 Apr 15 doi: 10.1007/s00280-008-0756-0. PMID: 18414864

Prognosis

Primary Esophageal Malignant Melanoma in Korea: Clinical features, Management and Prognosis.
Oh HH, Jung YW, Han B, Im CM, Yu HJ, Joo YE
Korean J Gastroenterol 2022 May 25;79(5):222-227. doi: 10.4166/kjg.2022.031. PMID: 35610553
Clinicopathological presentations and surgical outcomes of esophageal melanoma.
Urabe M, Haruta S, Ohkura Y, Inoshita N, Yago A, Koga S, Tanaka T, Ueno M, Udagawa H
Asian Cardiovasc Thorac Ann 2019 Sep;27(7):548-553. Epub 2019 Jul 18 doi: 10.1177/0218492319866064. PMID: 31319672
Patterns of care and survival outcomes in the treatment of esophageal melanoma.
Weiner JP, Shao M, Schwartz D, Wong A, Schreiber D
Dis Esophagus 2017 Feb 1;30(2):1-6. doi: 10.1111/dote.12504. PMID: 27862623
Esophageal melanocytosis morphologic features and review of the literature.
Chang F, Deere H
Arch Pathol Lab Med 2006 Apr;130(4):552-7. doi: 10.5858/2006-130-552-EMMFAR. PMID: 16594751
Mucosal malignant melanomas.
Iversen K, Robins RE
Am J Surg 1980 May;139(5):660-4. doi: 10.1016/0002-9610(80)90358-x. PMID: 7468915

Clinical prediction guides

Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker.
Silva-Oliveira RJ, Silva VA, Martinho O, Cruvinel-Carloni A, Melendez ME, Rosa MN, de Paula FE, de Souza Viana L, Carvalho AL, Reis RM
Cell Oncol (Dordr) 2016 Jun;39(3):253-63. Epub 2016 Feb 26 doi: 10.1007/s13402-016-0270-z. PMID: 26920031
Rapid and clinically significant response to masitinib in the treatment of mucosal primary esophageal melanoma with somatic KIT exon 11 mutation involving brain metastases: A case report.
Prosvicova J, Lukesova S, Kopecky J, Grim J, Papik Z, Kolarova R, Navratilova B, Dubreuil P, Agopian J, Mansfield C, Moussy A, Hermine O
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Dec;159(4):695-7. Epub 2015 Nov 27 doi: 10.5507/bp.2015.061. PMID: 26725706

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