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Flat urothelial hyperplasia

MedGen UID:
272633
•Concept ID:
C1333621
•
Pathologic Function
Synonyms: Flat Urothelial Hyperplasia; flat urothelial hyperplasia
 
Monarch Initiative: MONDO:0006212

Definition

A type of hyperplasia that is characterized by a marked thickening of the urinary tract epithelium. There is no evidence of cytologic atypia. -- 2003 [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlat urothelial hyperplasia

Professional guidelines

PubMed

Lewis(y) antigen (blood group 8, BG8) is a useful marker in the histopathological differential diagnosis of flat urothelial lesions of the urinary bladder.
Gunia S, Kakies C, May M, Koch S, Erbersdobler A
J Clin Pathol 2011 Aug;64(8):672-6. Epub 2011 Apr 21 doi: 10.1136/jclinpath-2011-200065. PMID: 21512109
Value of multicolour fluorescence in situ hybridisation (UroVysion) in the differential diagnosis of flat urothelial lesions.
Schwarz S, Rechenmacher M, Filbeck T, Knuechel R, Blaszyk H, Hartmann A, Brockhoff G
J Clin Pathol 2008 Mar;61(3):272-7. Epub 2007 Aug 10 doi: 10.1136/jcp.2007.049684. PMID: 17693577

Recent clinical studies

Etiology

No mutations of FGFR3 in normal urothelium in the vicinity of urothelial carcinoma of the bladder harbouring activating FGFR3 mutations in patients with bladder cancer.
Otto W, Denzinger S, Bertz S, Gaumann A, Wild PJ, Hartmann A, Stoehr R
Int J Cancer 2009 Nov 1;125(9):2205-8. doi: 10.1002/ijc.24598. PMID: 19621447

Diagnosis

Flat intraurothelial lesions of the urinary bladder-do hyperplasia, dysplasia, and atypia of unknown significance need to exist as diagnostic entities? and how to handle in routine clinical practice.
Paner GP, Smith SC, Hartmann A, Agarwal PK, Compérat E, Amin MB
Mod Pathol 2022 Oct;35(10):1296-1305. Epub 2022 Apr 25 doi: 10.1038/s41379-022-01087-7. PMID: 35468997
Dysplasia and carcinoma in situ of the urinary bladder.
Lopez-Beltran A, Marques RC, Montironi R, Reymundo C, Fonseca J, Cheng L
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):29-38. PMID: 26072632
Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation.
Lopez-Beltran A, Cheng L, Andersson L, Brausi M, de Matteis A, Montironi R, Sesterhenn I, van det Kwast KT, Mazerolles C
Virchows Arch 2002 Jan;440(1):3-11. doi: 10.1007/s00428-001-0577-6. PMID: 11942574

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