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Gastric small cell neuroendocrine carcinoma

MedGen UID:
272664
Concept ID:
C1333788
Neoplastic Process
Synonyms: gastric Oat cell carcinoma; Gastric Small Cell Carcinoma; gastric small cell carcinoma; Gastric Small Cell Neuroendocrine Carcinoma; gastric small cell neuroendocrine carcinoma; Oat cell carcinoma of stomach; Oat cell carcinoma of the stomach; Small Cell Carcinoma of Stomach; small cell carcinoma of stomach; Small Cell Carcinoma of the Stomach; small cell carcinoma of the stomach; stomach small cell carcinoma; STSC
 
Monarch Initiative: MONDO:0006229

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. It is characterized by the presence of malignant small cells. [from NCI]

Professional guidelines

PubMed

Thomas KEH, Voros BA, Boudreaux JP, Thiagarajan R, Woltering EA, Ramirez RA
Oncologist 2019 Aug;24(8):1076-1088. Epub 2019 Jan 11 doi: 10.1634/theoncologist.2018-0604. PMID: 30635447Free PMC Article
Nishida T, Goto O, Raut CP, Yahagi N
Cancer 2016 Oct 15;122(20):3110-3118. Epub 2016 Aug 1 doi: 10.1002/cncr.30239. PMID: 27478963Free PMC Article
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Recent clinical studies

Etiology

Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Diagnosis

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Liu Y, Chen X, Gao X, Chen JX, Chen J
J Oncol Pharm Pract 2020 Mar;26(2):465-470. Epub 2019 May 8 doi: 10.1177/1078155219846253. PMID: 31068089
Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, Bacchini G, Bocchi L, Piva E, Monfredo M, Scafuri V, Di Cesare P, Melotti B, Sequino M, Rimanti A, Binovi C, Ghisoni F, Caminiti C
Ann Palliat Med 2019 Sep;8(4):381-389. Epub 2019 Mar 14 doi: 10.21037/apm.2019.02.07. PMID: 30943735
Farrell PJ
Annu Rev Pathol 2019 Jan 24;14:29-53. Epub 2018 Aug 20 doi: 10.1146/annurev-pathmechdis-012418-013023. PMID: 30125149
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article

Therapy

Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
Markham A
Drugs 2021 Sep;81(14):1665-1670. doi: 10.1007/s40265-021-01584-0. PMID: 34455538
Vranić S, Bešlija S, Gatalica Z
Bosn J Basic Med Sci 2021 Feb 1;21(1):1-4. doi: 10.17305/bjbms.2020.4908. PMID: 32530388Free PMC Article
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, Martins R, Eaton K, Chen S, Salay TM, Alaparthy S, Grosso JF, Korman AJ, Parker SM, Agrawal S, Goldberg SM, Pardoll DM, Gupta A, Wigginton JM
N Engl J Med 2012 Jun 28;366(26):2455-65. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200694. PMID: 22658128Free PMC Article

Prognosis

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Mei D, Zhu Y, Zhang L, Wei W
Mediators Inflamm 2020;2020:9578701. Epub 2020 Aug 12 doi: 10.1155/2020/9578701. PMID: 32848510Free PMC Article
Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, Bacchini G, Bocchi L, Piva E, Monfredo M, Scafuri V, Di Cesare P, Melotti B, Sequino M, Rimanti A, Binovi C, Ghisoni F, Caminiti C
Ann Palliat Med 2019 Sep;8(4):381-389. Epub 2019 Mar 14 doi: 10.21037/apm.2019.02.07. PMID: 30943735
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article

Clinical prediction guides

Dong Y, Xu J, Sun B, Wang J, Wang Z
Mol Diagn Ther 2022 Mar;26(2):203-227. Epub 2022 Mar 10 doi: 10.1007/s40291-021-00568-w. PMID: 35266116Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R
Expert Opin Drug Deliv 2021 Feb;18(2):187-203. Epub 2020 Oct 5 doi: 10.1080/17425247.2021.1825376. PMID: 32954856
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, Martins R, Eaton K, Chen S, Salay TM, Alaparthy S, Grosso JF, Korman AJ, Parker SM, Agrawal S, Goldberg SM, Pardoll DM, Gupta A, Wigginton JM
N Engl J Med 2012 Jun 28;366(26):2455-65. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200694. PMID: 22658128Free PMC Article

Recent systematic reviews

Dong Y, Xu J, Sun B, Wang J, Wang Z
Mol Diagn Ther 2022 Mar;26(2):203-227. Epub 2022 Mar 10 doi: 10.1007/s40291-021-00568-w. PMID: 35266116Free PMC Article
Wu HX, Zhuo KQ, Wang K
Br J Clin Pharmacol 2022 May;88(5):2019-2034. Epub 2021 Dec 21 doi: 10.1111/bcp.15155. PMID: 34820879Free PMC Article
Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I
Rom J Morphol Embryol 2017;58(1):41-44. PMID: 28523296
Fiorino S, Bacchi-Reggiani L, de Biase D, Fornelli A, Masetti M, Tura A, Grizzi F, Zanello M, Mastrangelo L, Lombardi R, Acquaviva G, di Tommaso L, Bondi A, Visani M, Sabbatani S, Pontoriero L, Fabbri C, Cuppini A, Pession A, Jovine E
World J Gastroenterol 2015 Dec 7;21(45):12896-953. doi: 10.3748/wjg.v21.i45.12896. PMID: 26668515Free PMC Article
Gao P, Jiao SC, Bai L, Wang H, Jing FF, Yang JL
J Int Med Res 2013 Aug;41(4):923-33. doi: 10.1177/0300060513489789. PMID: 23908550

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